{
  "url": "https://dantelabs.com/traits/abnormal-vestibular-function",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-vestibular-function",
    "id": "HP:0001751",
    "name": "Abnormal vestibular function",
    "definition": "An abnormality of the functioning of the vestibular apparatus.",
    "synonyms": [
      "Impaired vestibular function",
      "Interictal vestibular dysfunction",
      "Vestibular function defect"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "functional-abnormality-of-the-inner-ear",
        "name": "Functional abnormality of the inner ear",
        "url": "https://dantelabs.com/traits/functional-abnormality-of-the-inner-ear"
      }
    ],
    "narrower": [
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "genes": 140,
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "vestibular-hyporeflexia",
        "name": "Vestibular hyporeflexia",
        "genes": 9,
        "url": "https://dantelabs.com/traits/vestibular-hyporeflexia"
      },
      {
        "slug": "abnormal-vestibulo-ocular-reflex",
        "name": "Abnormal vestibulo-ocular reflex",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-vestibulo-ocular-reflex"
      }
    ],
    "genes": [
      {
        "slug": "clic5",
        "symbol": "CLIC5",
        "hgnc": "HGNC:13517",
        "name": "CLIC family member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clic5"
      },
      {
        "slug": "espn",
        "symbol": "ESPN",
        "hgnc": "HGNC:13281",
        "name": "espin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/espn"
      },
      {
        "slug": "tmem132e",
        "symbol": "TMEM132E",
        "hgnc": "HGNC:26991",
        "name": "transmembrane protein 132E",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem132e"
      },
      {
        "slug": "pcdh15",
        "symbol": "PCDH15",
        "hgnc": "HGNC:14674",
        "name": "protocadherin related 15",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/pcdh15"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "clrn1",
        "symbol": "CLRN1",
        "hgnc": "HGNC:12605",
        "name": "clarin 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clrn1"
      },
      {
        "slug": "coch",
        "symbol": "COCH",
        "hgnc": "HGNC:2180",
        "name": "cochlin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coch"
      },
      {
        "slug": "myo7a",
        "symbol": "MYO7A",
        "hgnc": "HGNC:7606",
        "name": "myosin VIIA",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/myo7a"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "slc39a14",
        "symbol": "SLC39A14",
        "hgnc": "HGNC:20858",
        "name": "solute carrier family 39 member 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a14"
      },
      {
        "slug": "timm8a",
        "symbol": "TIMM8A",
        "hgnc": "HGNC:11817",
        "name": "translocase of inner mitochondrial membrane 8A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timm8a"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "ush1c",
        "symbol": "USH1C",
        "hgnc": "HGNC:12597",
        "name": "USH1 protein network component harmonin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ush1c"
      },
      {
        "slug": "ush1g",
        "symbol": "USH1G",
        "hgnc": "HGNC:16356",
        "name": "USH1 protein network component sans",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ush1g"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "arsg",
        "symbol": "ARSG",
        "hgnc": "HGNC:24102",
        "name": "arylsulfatase G",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsg"
      },
      {
        "slug": "atxn3",
        "symbol": "ATXN3",
        "hgnc": "HGNC:7106",
        "name": "ataxin 3",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atxn3"
      },
      {
        "slug": "cep78",
        "symbol": "CEP78",
        "hgnc": "HGNC:25740",
        "name": "centrosomal protein 78",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep78"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb3",
        "symbol": "GJB3",
        "hgnc": "HGNC:4285",
        "name": "gap junction protein beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb3"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "hars1",
        "symbol": "HARS1",
        "hgnc": "HGNC:4816",
        "name": "histidyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hars1"
      },
      {
        "slug": "jag1",
        "symbol": "JAG1",
        "hgnc": "HGNC:6188",
        "name": "jagged canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jag1"
      },
      {
        "slug": "mt-ts2",
        "symbol": "MT-TS2",
        "hgnc": "HGNC:7498",
        "name": "mitochondrially encoded tRNA-Ser (AGU/C) 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts2"
      },
      {
        "slug": "myo6",
        "symbol": "MYO6",
        "hgnc": "HGNC:7605",
        "name": "myosin VI",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo6"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "sox6",
        "symbol": "SOX6",
        "hgnc": "HGNC:16421",
        "name": "SRY-box transcription factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox6"
      },
      {
        "slug": "adgrv1",
        "symbol": "ADGRV1",
        "hgnc": "HGNC:17416",
        "name": "adhesion G protein-coupled receptor V1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adgrv1"
      },
      {
        "slug": "nars2",
        "symbol": "NARS2",
        "hgnc": "HGNC:26274",
        "name": "asparaginyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nars2"
      },
      {
        "slug": "pdzd7",
        "symbol": "PDZD7",
        "hgnc": "HGNC:26257",
        "name": "PDZ domain containing 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdzd7"
      },
      {
        "slug": "ush2a",
        "symbol": "USH2A",
        "hgnc": "HGNC:12601",
        "name": "usherin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ush2a"
      },
      {
        "slug": "whrn",
        "symbol": "WHRN",
        "hgnc": "HGNC:16361",
        "name": "whirlin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/whrn"
      },
      {
        "slug": "cacna1a",
        "symbol": "CACNA1A",
        "hgnc": "HGNC:1388",
        "name": "calcium voltage-gated channel subunit alpha1 A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1a"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "hgnc": "HGNC:24579",
        "name": "calcium and integrin binding family member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cib2"
      },
      {
        "slug": "foxi1",
        "symbol": "FOXI1",
        "hgnc": "HGNC:3815",
        "name": "forkhead box I1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxi1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "ptprq",
        "symbol": "PTPRQ",
        "hgnc": "HGNC:9679",
        "name": "protein tyrosine phosphatase receptor type Q",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprq"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      }
    ]
  }
}