{
  "url": "https://dantelabs.com/traits/abnormal-t-cell-proliferation",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-t-cell-proliferation",
    "id": "HP:0031379",
    "name": "Abnormal T cell proliferation",
    "definition": "Any abnormality in the multiplication or reproduction of T cells, which results in the expansion of a cell population.",
    "synonyms": [
      "Defective T cell proliferation"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-lymphocyte-proliferation",
        "name": "Abnormal lymphocyte proliferation",
        "url": "https://dantelabs.com/traits/abnormal-lymphocyte-proliferation"
      },
      {
        "slug": "abnormal-t-cell-physiology",
        "name": "Impaired T cell function",
        "url": "https://dantelabs.com/traits/abnormal-t-cell-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-mitogen-induced-t-cell-proliferation",
        "name": "Decreased mitogen-induced T-cell proliferation",
        "genes": 24,
        "url": "https://dantelabs.com/traits/decreased-mitogen-induced-t-cell-proliferation"
      },
      {
        "slug": "decreased-antigen-specific-t-cell-proliferation",
        "name": "Decreased antigen-specific T cell proliferation",
        "genes": 11,
        "url": "https://dantelabs.com/traits/decreased-antigen-specific-t-cell-proliferation"
      }
    ],
    "genes": [
      {
        "slug": "cd3e",
        "symbol": "CD3E",
        "hgnc": "HGNC:1674",
        "name": "CD3 epsilon subunit of T-cell receptor complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3e"
      },
      {
        "slug": "lat",
        "symbol": "LAT",
        "hgnc": "HGNC:18874",
        "name": "linker for activation of T cells",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lat"
      },
      {
        "slug": "lig1",
        "symbol": "LIG1",
        "hgnc": "HGNC:6598",
        "name": "DNA ligase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig1"
      },
      {
        "slug": "mrtfa",
        "symbol": "MRTFA",
        "hgnc": "HGNC:14334",
        "name": "myocardin related transcription factor A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrtfa"
      },
      {
        "slug": "rasgrp1",
        "symbol": "RASGRP1",
        "hgnc": "HGNC:9878",
        "name": "RAS guanyl releasing protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasgrp1"
      },
      {
        "slug": "wipf1",
        "symbol": "WIPF1",
        "hgnc": "HGNC:12736",
        "name": "WAS/WASL interacting protein family member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wipf1"
      },
      {
        "slug": "ctps1",
        "symbol": "CTPS1",
        "hgnc": "HGNC:2519",
        "name": "CTP synthase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctps1"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb1"
      }
    ]
  }
}