{
  "url": "https://dantelabs.com/traits/abnormal-rectum-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-rectum-morphology",
    "id": "HP:0002034",
    "name": "Abnormality of the rectum",
    "label": "Abnormal rectum morphology",
    "definition": "An abnormaltiy of the rectum, the final segment of the large intestine that stores solid waste until it passes through the anus.",
    "synonyms": [
      "Anomaly of the rectum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-large-intestine-morphology",
        "name": "Abnormality of the large intestine",
        "url": "https://dantelabs.com/traits/abnormal-large-intestine-morphology"
      },
      {
        "slug": "anorectal-anomaly",
        "name": "Anorectal anomaly",
        "url": "https://dantelabs.com/traits/anorectal-anomaly"
      }
    ],
    "narrower": [
      {
        "slug": "rectal-prolapse",
        "name": "Rectum protrudes through anus",
        "genes": 62,
        "url": "https://dantelabs.com/traits/rectal-prolapse"
      },
      {
        "slug": "neoplasm-of-the-rectum",
        "name": "Rectal tumor",
        "genes": 34,
        "url": "https://dantelabs.com/traits/neoplasm-of-the-rectum"
      },
      {
        "slug": "rectal-abscess",
        "name": "Rectal abscess",
        "genes": 10,
        "url": "https://dantelabs.com/traits/rectal-abscess"
      },
      {
        "slug": "rectal-atresia",
        "name": "Rectal atresia",
        "genes": 4,
        "url": "https://dantelabs.com/traits/rectal-atresia"
      },
      {
        "slug": "megarectum",
        "name": "Megarectum",
        "genes": 2,
        "url": "https://dantelabs.com/traits/megarectum"
      },
      {
        "slug": "anorectal-abscess",
        "name": "Anorectal abscess",
        "genes": 1,
        "url": "https://dantelabs.com/traits/anorectal-abscess"
      },
      {
        "slug": "hemorrhoids",
        "name": "Haemorrhoids",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hemorrhoids"
      },
      {
        "slug": "rectal-duplication",
        "name": "Rectal duplication",
        "genes": 1,
        "url": "https://dantelabs.com/traits/rectal-duplication"
      },
      {
        "slug": "rectal-fistula",
        "name": "Rectal fistula",
        "genes": 1,
        "url": "https://dantelabs.com/traits/rectal-fistula"
      }
    ],
    "genes": [
      {
        "slug": "pigv",
        "symbol": "PIGV",
        "hgnc": "HGNC:26031",
        "name": "phosphatidylinositol glycan anchor biosynthesis class V",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigv"
      },
      {
        "slug": "cox7b",
        "symbol": "COX7B",
        "hgnc": "HGNC:2291",
        "name": "cytochrome c oxidase subunit 7B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox7b"
      },
      {
        "slug": "hccs",
        "symbol": "HCCS",
        "hgnc": "HGNC:4837",
        "name": "holocytochrome c synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hccs"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "alk",
        "symbol": "ALK",
        "hgnc": "HGNC:427",
        "name": "ALK receptor tyrosine kinase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alk"
      }
    ]
  }
}