{
  "url": "https://dantelabs.com/traits/abnormal-intervertebral-disk-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-intervertebral-disk-morphology",
    "id": "HP:0005108",
    "name": "Abnormal intervertebral disk morphology",
    "definition": "Any structural abnormality of the intervertebral disk.",
    "synonyms": [
      "Abnormality of the intervertebral disc",
      "Abnormality of the intervertebral disk"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-vertebral-column",
        "name": "Abnormality of the vertebral column",
        "url": "https://dantelabs.com/traits/abnormality-of-the-vertebral-column"
      }
    ],
    "narrower": [
      {
        "slug": "intervertebral-space-narrowing",
        "name": "Intervertebral space narrowing",
        "genes": 10,
        "url": "https://dantelabs.com/traits/intervertebral-space-narrowing"
      },
      {
        "slug": "intervertebral-disk-degeneration",
        "name": "Intervertebral disk degeneration",
        "genes": 7,
        "url": "https://dantelabs.com/traits/intervertebral-disk-degeneration"
      },
      {
        "slug": "increased-intervertebral-space",
        "name": "Increased intervertebral space",
        "genes": 6,
        "url": "https://dantelabs.com/traits/increased-intervertebral-space"
      },
      {
        "slug": "intervertebral-disk-calcification",
        "name": "Intervertebral disk calcification",
        "genes": 3,
        "url": "https://dantelabs.com/traits/intervertebral-disk-calcification"
      },
      {
        "slug": "herniation-of-intervertebral-nuclei",
        "name": "Herniated disk",
        "genes": 2,
        "url": "https://dantelabs.com/traits/herniation-of-intervertebral-nuclei"
      }
    ],
    "genes": [
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "dll3",
        "symbol": "DLL3",
        "hgnc": "HGNC:2909",
        "name": "delta like canonical Notch ligand 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll3"
      },
      {
        "slug": "hes7",
        "symbol": "HES7",
        "hgnc": "HGNC:15977",
        "name": "hes family bHLH transcription factor 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hes7"
      },
      {
        "slug": "lfng",
        "symbol": "LFNG",
        "hgnc": "HGNC:6560",
        "name": "LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lfng"
      },
      {
        "slug": "mesp2",
        "symbol": "MESP2",
        "hgnc": "HGNC:29659",
        "name": "mesoderm posterior bHLH transcription factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mesp2"
      },
      {
        "slug": "ripply2",
        "symbol": "RIPPLY2",
        "hgnc": "HGNC:21390",
        "name": "ripply transcriptional repressor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ripply2"
      },
      {
        "slug": "rnu4atac",
        "symbol": "RNU4ATAC",
        "hgnc": "HGNC:34016",
        "name": "RNA, U4atac small nuclear",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4atac"
      },
      {
        "slug": "tbx6",
        "symbol": "TBX6",
        "hgnc": "HGNC:11605",
        "name": "T-box transcription factor 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx6"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv4"
      },
      {
        "slug": "xylt2",
        "symbol": "XYLT2",
        "hgnc": "HGNC:15517",
        "name": "xylosyltransferase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xylt2"
      },
      {
        "slug": "gon7",
        "symbol": "GON7",
        "hgnc": "HGNC:20356",
        "name": "GON7 subunit of KEOPS complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gon7"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "lage3",
        "symbol": "LAGE3",
        "hgnc": "HGNC:26058",
        "name": "L antigen family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lage3"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "nup133",
        "symbol": "NUP133",
        "hgnc": "HGNC:18016",
        "name": "nucleoporin 133",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup133"
      },
      {
        "slug": "osgep",
        "symbol": "OSGEP",
        "hgnc": "HGNC:18028",
        "name": "O-sialoglycoprotein endopeptidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/osgep"
      },
      {
        "slug": "ppp1cb",
        "symbol": "PPP1CB",
        "hgnc": "HGNC:9282",
        "name": "protein phosphatase 1 catalytic subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1cb"
      },
      {
        "slug": "shoc2",
        "symbol": "SHOC2",
        "hgnc": "HGNC:15454",
        "name": "SHOC2 leucine rich repeat scaffold protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shoc2"
      },
      {
        "slug": "tp53rk",
        "symbol": "TP53RK",
        "hgnc": "HGNC:16197",
        "name": "TP53 regulating kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53rk"
      },
      {
        "slug": "tprkb",
        "symbol": "TPRKB",
        "hgnc": "HGNC:24259",
        "name": "TP53RK binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tprkb"
      },
      {
        "slug": "wdr4",
        "symbol": "WDR4",
        "hgnc": "HGNC:12756",
        "name": "WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr4"
      },
      {
        "slug": "wdr73",
        "symbol": "WDR73",
        "hgnc": "HGNC:25928",
        "name": "WD repeat domain 73",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr73"
      },
      {
        "slug": "yrdc",
        "symbol": "YRDC",
        "hgnc": "HGNC:28905",
        "name": "yrdC N6-threonylcarbamoyltransferase domain containing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yrdc"
      }
    ]
  }
}