{
  "url": "https://dantelabs.com/traits/abnormal-circulating-electrolyte-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-electrolyte-concentration",
    "id": "HP:0003111",
    "name": "Electrolyte disorders",
    "label": "Abnormal circulating electrolyte concentration",
    "definition": "Abnormality of the homeostasis (concentration) of a monoatomic ion.",
    "synonyms": [
      "Abnormal blood ion concentration",
      "Abnormality of ion homeostasis",
      "Electrolyte disturbance"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-circulating-inorganic-anion-concentration",
        "name": "Abnormal circulating inorganic anion concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-inorganic-anion-concentration"
      },
      {
        "slug": "abnormal-circulating-inorganic-cation-concentration",
        "name": "Abnormal circulating inorganic cation concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-inorganic-cation-concentration"
      }
    ],
    "genes": [
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamc2"
      }
    ]
  }
}