{
  "url": "https://dantelabs.com/nl/genes/vim",
  "gene": {
    "slug": "vim",
    "symbol": "VIM",
    "name": "vimentin",
    "hgnc": "HGNC:12692",
    "summary": null,
    "location": "10p13",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000026025",
    "entrezId": 7431,
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    "uniprot": [
      "P08670"
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    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 17228241,
      "end": 17237593,
      "strand": "+",
      "ensemblTranscript": "ENST00000544301.7",
      "refseqTranscript": "NM_003380.5",
      "ensemblProtein": "ENSP00000446007.1",
      "refseqProtein": "NP_003371.2",
      "exons": [
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        {
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      ],
      "cds": {
        "start": 17229423,
        "end": 17237271
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 17270258,
      "end": 17279592,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 16732917,
      "end": 17732916,
      "genes": [
        {
          "symbol": "RSU1",
          "ensemblId": "ENSG00000148484",
          "biotype": "protein_coding",
          "start": 16567276,
          "end": 16817603,
          "strand": "-",
          "slug": "rsu1"
        },
        {
          "symbol": "CUBN",
          "ensemblId": "ENSG00000107611",
          "biotype": "protein_coding",
          "start": 16823966,
          "end": 17129970,
          "strand": "-",
          "slug": "cubn"
        },
        {
          "symbol": "TRDMT1",
          "ensemblId": "ENSG00000107614",
          "biotype": "protein_coding",
          "start": 17137336,
          "end": 17202054,
          "strand": "-",
          "slug": "trdmt1"
        },
        {
          "symbol": "ST8SIA6",
          "ensemblId": "ENSG00000148488",
          "biotype": "protein_coding",
          "start": 17315416,
          "end": 17454681,
          "strand": "-",
          "slug": "st8sia6"
        },
        {
          "symbol": "HACD1",
          "ensemblId": "ENSG00000165996",
          "biotype": "protein_coding",
          "start": 17588301,
          "end": 17617566,
          "strand": "-",
          "slug": "hacd1"
        },
        {
          "symbol": "STAM",
          "ensemblId": "ENSG00000136738",
          "biotype": "protein_coding",
          "start": 17644124,
          "end": 17735901,
          "strand": "+",
          "slug": "stam"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-congenital-and-juvenile-cataract",
        "name": "Erfelijke aangeboren en juveniele cataract",
        "diseases": [
          {
            "mondoId": "MONDO:0011060",
            "name": "Niet-syndromale cataract met vroege start",
            "genes": 22,
            "inheritance": null,
            "description": "Cataract die bij de geboorte of vroeg in het leven ontstaat zonder andere kenmerken, veroorzaakt door veranderingen in lensgenen zoals de crystallinen (CRYAA, CRYBB2, CRYGD en andere), GJA3, GJA8 en MIP.",
            "management": "Vroege opsporing en operatie bij kinderen helpen blijvend zichtverlies door amblyopie voorkomen, en familieleden kunnen worden aangeboden om hun ogen te laten controleren.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/hereditary-congenital-and-juvenile-cataract"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "diffuse-nuclear-cataract",
        "name": "Diffuse nuclear cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/diffuse-nuclear-cataract"
      },
      {
        "slug": "posterior-polar-cataract",
        "name": "Posterior polar cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/posterior-polar-cataract"
      },
      {
        "slug": "pulverulent-cataract",
        "name": "Pulverulent cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pulverulent-cataract"
      }
    ],
    "related": [
      {
        "slug": "bfsp1",
        "symbol": "BFSP1",
        "name": "beaded filament structural protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/bfsp1"
      },
      {
        "slug": "chmp4b",
        "symbol": "CHMP4B",
        "name": "charged multivesicular body protein 4B",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/chmp4b"
      },
      {
        "slug": "cryab",
        "symbol": "CRYAB",
        "name": "crystallin alpha B",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/cryab"
      },
      {
        "slug": "cryba1",
        "symbol": "CRYBA1",
        "name": "crystallin beta A1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/cryba1"
      },
      {
        "slug": "cryba2",
        "symbol": "CRYBA2",
        "name": "crystallin beta A2",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/cryba2"
      },
      {
        "slug": "cryba4",
        "symbol": "CRYBA4",
        "name": "crystallin beta A4",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/cryba4"
      },
      {
        "slug": "crybb1",
        "symbol": "CRYBB1",
        "name": "crystallin beta B1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/crybb1"
      },
      {
        "slug": "crybb3",
        "symbol": "CRYBB3",
        "name": "crystallin beta B3",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/crybb3"
      },
      {
        "slug": "crygs",
        "symbol": "CRYGS",
        "name": "crystallin gamma S",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/crygs"
      },
      {
        "slug": "epha2",
        "symbol": "EPHA2",
        "name": "EPH receptor A2",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/epha2"
      },
      {
        "slug": "gcnt2",
        "symbol": "GCNT2",
        "name": "glucosaminyl (N-acetyl) transferase 2 (I blood group)",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/gcnt2"
      },
      {
        "slug": "gja3",
        "symbol": "GJA3",
        "name": "gap junction protein alpha 3",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/gja3"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}