{
  "url": "https://dantelabs.com/nl/genes/trim37",
  "gene": {
    "slug": "trim37",
    "symbol": "TRIM37",
    "name": "tripartite motif containing 37",
    "hgnc": "HGNC:7523",
    "summary": null,
    "location": "17q22",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA0898",
      "POB1",
      "TEF3"
    ],
    "previousSymbols": [
      "MUL"
    ],
    "ensemblId": "ENSG00000108395",
    "entrezId": 4591,
    "omim": [
      "605073"
    ],
    "uniprot": [
      "O94972"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 58998202,
      "end": 59106880,
      "strand": "-",
      "ensemblTranscript": "ENST00000262294.12",
      "refseqTranscript": "NM_015294.6",
      "ensemblProtein": "ENSP00000262294.7",
      "refseqProtein": "NP_056109.1",
      "exons": [
        {
          "start": 58998202,
          "end": 58999459
        },
        {
          "start": 59001598,
          "end": 59001714
        },
        {
          "start": 59012328,
          "end": 59012446
        },
        {
          "start": 59015610,
          "end": 59015799
        },
        {
          "start": 59017296,
          "end": 59017424
        },
        {
          "start": 59028415,
          "end": 59028723
        },
        {
          "start": 59031896,
          "end": 59032090
        },
        {
          "start": 59041813,
          "end": 59041898
        },
        {
          "start": 59047683,
          "end": 59047819
        },
        {
          "start": 59049178,
          "end": 59049393
        },
        {
          "start": 59051214,
          "end": 59051328
        },
        {
          "start": 59056875,
          "end": 59057054
        },
        {
          "start": 59061032,
          "end": 59061108
        },
        {
          "start": 59062567,
          "end": 59062648
        },
        {
          "start": 59064355,
          "end": 59064405
        },
        {
          "start": 59070823,
          "end": 59070947
        },
        {
          "start": 59075647,
          "end": 59075714
        },
        {
          "start": 59079754,
          "end": 59079877
        },
        {
          "start": 59081097,
          "end": 59081219
        },
        {
          "start": 59084002,
          "end": 59084089
        },
        {
          "start": 59088291,
          "end": 59088407
        },
        {
          "start": 59091300,
          "end": 59091340
        },
        {
          "start": 59104293,
          "end": 59104394
        },
        {
          "start": 59106441,
          "end": 59106880
        }
      ],
      "cds": {
        "start": 58999377,
        "end": 59106461
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 57059999,
      "end": 57184282,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 58552541,
      "end": 59552540,
      "genes": [
        {
          "symbol": "TEX14",
          "ensemblId": "ENSG00000121101",
          "biotype": "protein_coding",
          "start": 58556678,
          "end": 58692055,
          "strand": "-",
          "slug": "tex14"
        },
        {
          "symbol": "IGBP1C",
          "ensemblId": "ENSG00000266826",
          "biotype": "protein_coding",
          "start": 58660424,
          "end": 58692055,
          "strand": "-",
          "slug": "igbp1c"
        },
        {
          "symbol": "RAD51C",
          "ensemblId": "ENSG00000108384",
          "biotype": "protein_coding",
          "start": 58692569,
          "end": 58735611,
          "strand": "+",
          "slug": "rad51c"
        },
        {
          "symbol": "PPM1E",
          "ensemblId": "ENSG00000175175",
          "biotype": "protein_coding",
          "start": 58755851,
          "end": 58985179,
          "strand": "+",
          "slug": "ppm1e"
        },
        {
          "symbol": "SKA2",
          "ensemblId": "ENSG00000182628",
          "biotype": "protein_coding",
          "start": 59109857,
          "end": 59155260,
          "strand": "-",
          "slug": "ska2"
        },
        {
          "symbol": "PRR11",
          "ensemblId": "ENSG00000068489",
          "biotype": "protein_coding",
          "start": 59155732,
          "end": 59206709,
          "strand": "+",
          "slug": "prr11"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000265303",
          "biotype": "protein_coding",
          "start": 59197566,
          "end": 59215226,
          "strand": "+"
        },
        {
          "symbol": "SMG8",
          "ensemblId": "ENSG00000167447",
          "biotype": "protein_coding",
          "start": 59209400,
          "end": 59215249,
          "strand": "+",
          "slug": "smg8"
        },
        {
          "symbol": "GDPD1",
          "ensemblId": "ENSG00000153982",
          "biotype": "protein_coding",
          "start": 59220467,
          "end": 59275970,
          "strand": "+",
          "slug": "gdpd1"
        },
        {
          "symbol": "YPEL2",
          "ensemblId": "ENSG00000175155",
          "biotype": "protein_coding",
          "start": 59331591,
          "end": 59401729,
          "strand": "+",
          "slug": "ypel2"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "microglossia",
        "name": "Abnormally small tongue",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/microglossia"
      },
      {
        "slug": "absent-frontal-sinuses",
        "name": "Absent frontal sinuses",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/absent-frontal-sinuses"
      },
      {
        "slug": "ascites",
        "name": "Accumulation of fluid in the abdomen",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ascites"
      },
      {
        "slug": "astigmatism",
        "name": "Astigmatism",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/astigmatism"
      },
      {
        "slug": "dental-malocclusion",
        "name": "Bad bite",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dental-malocclusion"
      },
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/macrocephaly"
      },
      {
        "slug": "congestive-heart-failure",
        "name": "Cardiac failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/congestive-heart-failure"
      },
      {
        "slug": "iris-coloboma",
        "name": "Cat eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/iris-coloboma"
      },
      {
        "slug": "corneal-dystrophy",
        "name": "Corneal dystrophy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/corneal-dystrophy"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "dental-crowding",
        "name": "Dental crowding",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/dental-crowding"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "dysarthria",
        "name": "Difficulty articulating speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/dysarthria"
      },
      {
        "slug": "diminished-deep-tendon-reflex",
        "name": "Diminished deep tendon reflex",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/diminished-deep-tendon-reflex"
      },
      {
        "slug": "cardiomegaly",
        "name": "Enlarged heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cardiomegaly"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "hypodontia",
        "name": "Failure of development of between one and six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/hypodontia"
      },
      {
        "slug": "frontal-bossing",
        "name": "Frontal bossing",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/frontal-bossing"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "abnormally-high-pitched-voice",
        "name": "High pitched voice",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormally-high-pitched-voice"
      },
      {
        "slug": "hydrops-fetalis",
        "name": "Hydrops fetalis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hydrops-fetalis"
      },
      {
        "slug": "hypoplastic-frontal-sinuses",
        "name": "Hypoplastic frontal sinuses",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplastic-frontal-sinuses"
      },
      {
        "slug": "mild-intellectual-disability",
        "name": "Intellectual disability, mild",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/mild-intellectual-disability"
      },
      {
        "slug": "j-shaped-sella-turcica",
        "name": "J-shaped sella turcica",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/j-shaped-sella-turcica"
      },
      {
        "slug": "dolichocephaly",
        "name": "Long, narrow head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/dolichocephaly"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "myocardial-fibrosis",
        "name": "Myocardial fibrosis",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/myocardial-fibrosis"
      },
      {
        "slug": "nephroblastoma",
        "name": "Nephroblastoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nephroblastoma"
      },
      {
        "slug": "pericardial-constriction",
        "name": "Pericardial constriction",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pericardial-constriction"
      },
      {
        "slug": "pigmentary-retinopathy",
        "name": "Pigmentary retinopathy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/pigmentary-retinopathy"
      },
      {
        "slug": "nevus-flammeus",
        "name": "port-wine stain",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nevus-flammeus"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "single-transverse-palmar-crease",
        "name": "Single transverse palmar crease",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/single-transverse-palmar-crease"
      },
      {
        "slug": "thickened-cortex-of-long-bones",
        "name": "Thickened cortex of long bones",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thickened-cortex-of-long-bones"
      },
      {
        "slug": "enamel-hypoplasia",
        "name": "Thin dental enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/enamel-hypoplasia"
      },
      {
        "slug": "triangular-face",
        "name": "Triangular face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/triangular-face"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      },
      {
        "slug": "cachexia",
        "name": "Wasting syndrome",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cachexia"
      },
      {
        "slug": "weak-voice",
        "name": "Weak voice",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/weak-voice"
      },
      {
        "slug": "wide-nasal-bridge",
        "name": "Wide nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/wide-nasal-bridge"
      },
      {
        "slug": "wide-nose",
        "name": "Wide nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/wide-nose"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}