{
  "url": "https://dantelabs.com/nl/genes/slitrk6",
  "gene": {
    "slug": "slitrk6",
    "symbol": "SLITRK6",
    "name": "SLIT and NTRK like family member 6",
    "hgnc": "HGNC:23503",
    "summary": null,
    "location": "13q31.1",
    "locusType": "gene with protein product",
    "aliases": [
      "FLJ22774"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000184564",
    "entrezId": 84189,
    "omim": [
      "609681"
    ],
    "uniprot": [
      "Q9H5Y7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 85792790,
      "end": 85799419,
      "strand": "-",
      "ensemblTranscript": "ENST00000647374.2",
      "refseqTranscript": "NM_032229.3",
      "ensemblProtein": "ENSP00000495507.1",
      "refseqProtein": "NP_115605.2",
      "exons": [
        {
          "start": 85792790,
          "end": 85796532
        },
        {
          "start": 85798914,
          "end": 85799419
        }
      ],
      "cds": {
        "start": 85793983,
        "end": 85796508
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 86366925,
      "end": 86373623,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 85296105,
      "end": 86296104,
      "genes": [],
      "truncated": false
    },
    "reports": [
      {
        "slug": "high-myopia-sensorineural-deafness-slitrk6",
        "name": "Hoge myopie met sensorineurale doofheid",
        "diseases": [
          {
            "mondoId": "MONDO:0009082",
            "name": "Syndroom van hoge myopie en sensorineurale doofheid",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Veroorzaakt door veranderingen in beide kopieën van SLITRK6, dat helpt bij de vorming van zenuwverbindingen in het binnenoor en de groei van het oog beïnvloedt. Er zijn meldingen uit verschillende bevolkingsgroepen.",
            "management": "Vroege gehoortests bepalen of een gehoorapparaat of cochleair implantaat en communicatieondersteuning nodig zijn; een bril of contactlenzen corrigeren de myopie, en regelmatige oogcontroles houden in de gaten of er complicaties van hoge myopie optreden. Ouders zijn meestal draagster of drager, dus draagstertesten voor familieleden en erfelijkheidsadvies zijn beschikbaar.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/high-myopia-sensorineural-deafness-slitrk6"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "high-myopia",
        "name": "Severe near sightedness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/high-myopia"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}