{
  "url": "https://dantelabs.com/nl/genes/six1",
  "gene": {
    "slug": "six1",
    "symbol": "SIX1",
    "name": "SIX homeobox 1",
    "hgnc": "HGNC:10887",
    "summary": null,
    "location": "14q23.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "DFNA23"
    ],
    "ensemblId": "ENSG00000126778",
    "entrezId": 6495,
    "omim": [
      "601205"
    ],
    "uniprot": [
      "Q15475"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "14",
      "start": 60643421,
      "end": 60649477,
      "strand": "-",
      "ensemblTranscript": "ENST00000645694.3",
      "refseqTranscript": "NM_005982.4",
      "ensemblProtein": "ENSP00000494686.1",
      "refseqProtein": "NP_005973.1",
      "exons": [
        {
          "start": 60643421,
          "end": 60646577
        },
        {
          "start": 60648630,
          "end": 60649477
        }
      ],
      "cds": {
        "start": 60646283,
        "end": 60649189
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "14",
      "start": 61110133,
      "end": 61124977,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 60146449,
      "end": 61146448,
      "genes": [
        {
          "symbol": "PCNX4",
          "ensemblId": "ENSG00000126773",
          "biotype": "protein_coding",
          "start": 60091910,
          "end": 60171377,
          "strand": "+",
          "slug": "pcnx4"
        },
        {
          "symbol": "DHRS7",
          "ensemblId": "ENSG00000100612",
          "biotype": "protein_coding",
          "start": 60140808,
          "end": 60169856,
          "strand": "-",
          "slug": "dhrs7"
        },
        {
          "symbol": "PPM1A",
          "ensemblId": "ENSG00000100614",
          "biotype": "protein_coding",
          "start": 60245752,
          "end": 60299223,
          "strand": "+",
          "slug": "ppm1a"
        },
        {
          "symbol": "C14orf39",
          "ensemblId": "ENSG00000179008",
          "biotype": "protein_coding",
          "start": 60396469,
          "end": 60515543,
          "strand": "-",
          "slug": "c14orf39"
        },
        {
          "symbol": "SIX6",
          "ensemblId": "ENSG00000184302",
          "biotype": "protein_coding",
          "start": 60509146,
          "end": 60512850,
          "strand": "+",
          "slug": "six6"
        },
        {
          "symbol": "SIX4",
          "ensemblId": "ENSG00000100625",
          "biotype": "protein_coding",
          "start": 60709539,
          "end": 60724362,
          "strand": "-",
          "slug": "six4"
        },
        {
          "symbol": "MNAT1",
          "ensemblId": "ENSG00000020426",
          "biotype": "protein_coding",
          "start": 60734733,
          "end": 60973862,
          "strand": "+",
          "slug": "mnat1"
        },
        {
          "symbol": "TRMT5",
          "ensemblId": "ENSG00000126814",
          "biotype": "protein_coding",
          "start": 60971441,
          "end": 60981694,
          "strand": "-",
          "slug": "trmt5"
        },
        {
          "symbol": "SLC38A6",
          "ensemblId": "ENSG00000139974",
          "biotype": "protein_coding",
          "start": 60981106,
          "end": 61114316,
          "strand": "+",
          "slug": "slc38a6"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "branchio-oto-renal-spectrum-disorder",
        "name": "Branchio-Oto-Renaal Spectrumstoornis",
        "diseases": [
          {
            "mondoId": "MONDO:0007029",
            "name": "Branchio-Oto-Renaal Spectrumstoornis",
            "genes": 3,
            "inheritance": "autosomal-dominant",
            "description": "Een dominante aandoening, voornamelijk veroorzaakt door veranderingen in EYA1, SIX1 of SIX5, die geleidings-, sensorineuraal of gemengd gehoorverlies, misvormingen van het oor, cysten of putjes in de hals en, bij sommige mensen, nieuwe afwijkingen aan de nieren veroorzaakt.",
            "management": "Door hiervan op de hoogte te zijn, kunt u laten onderzoeken of u gehoorproblemen heeft en is er reden voor echografische controle van de nieren. Ook helpt het bij erfelijkheidsadvies voor uw familie.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/branchio-oto-renal-spectrum-disorder"
      },
      {
        "slug": "congenital-anomalies-kidney-urinary-tract",
        "name": "Aangeboren afwijkingen van de nier en urinewegen",
        "diseases": [
          {
            "mondoId": "MONDO:0007029",
            "name": "Branchio-oto-renaal syndroom",
            "genes": 3,
            "inheritance": "autosomal-dominant",
            "description": "Een aandoening veroorzaakt door varianten in EYA1 of SIX1, die de hals, oren, het gehoor en de nieren aantast.",
            "management": "Als u dit weet, is gehooronderzoek en beeldvorming van de nieren aangewezen.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/congenital-anomalies-kidney-urinary-tract"
      },
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Gehoorverlies en doofheid",
        "diseases": [
          {
            "mondoId": "MONDO:0019587",
            "name": "Autosomaal dominant niet-syndromaal gehoorverlies",
            "genes": 39,
            "inheritance": "autosomal-dominant",
            "description": "Autosomaal dominante vorm van niet-syndromale doofheid.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0019497",
            "name": "Niet-syndromale erfelijke gehoorstoornis",
            "genes": 97,
            "inheritance": null,
            "description": "Erfelijk gehoorverlies zonder andere medische kenmerken, inclusief de veelvoorkomende recessieve vormen veroorzaakt door GJB2, OTOF, SLC26A4, STRC en vele andere genen, evenals dominante, X-gebonden en mitochondriale vormen.",
            "management": "Het kennen van de genetische oorzaak kan helpen bij keuzes rond gehoorondersteuning en cochleaire implantaten, bij de geschiktheid voor deelname aan onderzoeken naar genetherapie (bijvoorbeeld bij OTOF) en bij erfelijkheidsadvies voor familieleden.",
            "evidence": {
              "gencc": [
                "G2P",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-lacrimal-duct-morphology",
        "name": "Abnormal lacrimal duct morphology",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-lacrimal-duct-morphology"
      },
      {
        "slug": "abnormal-lateral-semicircular-canal-morphology",
        "name": "Abnormal lateral semicircular canal morphology",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-lateral-semicircular-canal-morphology"
      },
      {
        "slug": "abnormal-nasolacrimal-system-morphology",
        "name": "Abnormal nasolacrimal system morphology",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-nasolacrimal-system-morphology"
      },
      {
        "slug": "abnormal-renal-collecting-system-morphology",
        "name": "Abnormal renal collecting system morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-renal-collecting-system-morphology"
      },
      {
        "slug": "renal-malrotation",
        "name": "Abnormal rotation of the kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-malrotation"
      },
      {
        "slug": "lacrimation-abnormality",
        "name": "Abnormality of tear production",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/lacrimation-abnormality"
      },
      {
        "slug": "abnormality-of-the-inner-ear",
        "name": "Abnormality of the inner ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-inner-ear"
      },
      {
        "slug": "abnormality-of-the-middle-ear",
        "name": "Abnormality of the middle ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-middle-ear"
      },
      {
        "slug": "abnormality-of-the-middle-ear-ossicles",
        "name": "Abnormality of the middle ear ossicles",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-middle-ear-ossicles"
      },
      {
        "slug": "abnormality-of-the-outer-ear",
        "name": "Abnormality of the outer ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-outer-ear"
      },
      {
        "slug": "abnormal-pinna-morphology",
        "name": "Abnormally shaped ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-pinna-morphology"
      },
      {
        "slug": "atresia-of-the-external-auditory-canal",
        "name": "Absent ear canal",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atresia-of-the-external-auditory-canal"
      },
      {
        "slug": "unilateral-renal-agenesis",
        "name": "Absent kidney on one side",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/unilateral-renal-agenesis"
      },
      {
        "slug": "lacrimal-duct-aplasia",
        "name": "Absent tear duct",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lacrimal-duct-aplasia"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-cochlea",
        "name": "Absent/small cochlea",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-cochlea"
      },
      {
        "slug": "renal-hypoplasia-aplasia",
        "name": "Absent/small kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/renal-hypoplasia-aplasia"
      },
      {
        "slug": "facial-palsy",
        "name": "Bell's palsy",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/facial-palsy"
      },
      {
        "slug": "bifid-uvula",
        "name": "Bifid uvula",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/bifid-uvula"
      },
      {
        "slug": "branchial-anomaly",
        "name": "Branchial anomaly",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/branchial-anomaly"
      },
      {
        "slug": "branchial-cyst",
        "name": "Branchial cyst",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/branchial-cyst"
      },
      {
        "slug": "branchial-fistula",
        "name": "Branchial fistula",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/branchial-fistula"
      },
      {
        "slug": "branchial-sinus",
        "name": "Branchial sinus",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/branchial-sinus"
      },
      {
        "slug": "cholesteatoma",
        "name": "Cholesteatoma",
        "systems": [
          "abnormality-of-the-ear",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/cholesteatoma"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cleft-palate"
      },
      {
        "slug": "conductive-hearing-impairment",
        "name": "Conductive deafness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/conductive-hearing-impairment"
      },
      {
        "slug": "cupped-ear",
        "name": "Cupped ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cupped-ear"
      },
      {
        "slug": "microdontia",
        "name": "Decreased size of tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/microdontia"
      },
      {
        "slug": "increased-overbite",
        "name": "Deep bite",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/increased-overbite"
      },
      {
        "slug": "dilatated-internal-auditory-canal",
        "name": "Dilatated internal auditory canal",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/dilatated-internal-auditory-canal"
      },
      {
        "slug": "dilatation-of-renal-calices",
        "name": "Dilatation of renal calices",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dilatation-of-renal-calices"
      },
      {
        "slug": "congenital-hip-dislocation",
        "name": "Dislocated hip since birth",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/congenital-hip-dislocation"
      },
      {
        "slug": "enlarged-cochlear-aqueduct",
        "name": "Enlarged cochlear aqueduct",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enlarged-cochlear-aqueduct"
      },
      {
        "slug": "enlarged-vestibular-aqueduct",
        "name": "Enlarged vestibular aqueduct",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enlarged-vestibular-aqueduct"
      },
      {
        "slug": "euthyroid-goiter",
        "name": "Euthyroid goiter",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/euthyroid-goiter"
      },
      {
        "slug": "facial-asymmetry",
        "name": "Facial asymmetry",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/facial-asymmetry"
      },
      {
        "slug": "renal-steatosis",
        "name": "Fatty kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-steatosis"
      },
      {
        "slug": "gustatory-lacrimation",
        "name": "Gustatory lacrimation",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gustatory-lacrimation"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "high-palate",
        "name": "High palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/high-palate"
      },
      {
        "slug": "hydronephrosis",
        "name": "Hydronephrosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hydronephrosis"
      },
      {
        "slug": "hypoplasia-of-the-cochlea",
        "name": "Hypoplasia of the cochlea",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-cochlea"
      },
      {
        "slug": "incomplete-partition-of-the-cochlea-type-ii",
        "name": "Incomplete partition of the cochlea type II",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/incomplete-partition-of-the-cochlea-type-ii"
      },
      {
        "slug": "intestinal-malrotation",
        "name": "Intestinal malrotation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/intestinal-malrotation"
      },
      {
        "slug": "lip-pit",
        "name": "Lip pit",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lip-pit"
      },
      {
        "slug": "commissural-lip-pit",
        "name": "Lip pits at corners of the mouth",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/commissural-lip-pit"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "long-face",
        "name": "Long face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/long-face"
      },
      {
        "slug": "lop-ear",
        "name": "Lop ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/lop-ear"
      },
      {
        "slug": "abnormal-middle-ear-morphology",
        "name": "Middle ear malformation",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-middle-ear-morphology"
      },
      {
        "slug": "mild-global-developmental-delay",
        "name": "Mild global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/mild-global-developmental-delay"
      },
      {
        "slug": "mixed-hearing-impairment",
        "name": "Mixed hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mixed-hearing-impairment"
      },
      {
        "slug": "multicystic-kidney-dysplasia",
        "name": "Multicystic kidney dysplasia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/multicystic-kidney-dysplasia"
      },
      {
        "slug": "stenosis-of-the-external-auditory-canal",
        "name": "Narrow ear canal",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stenosis-of-the-external-auditory-canal"
      },
      {
        "slug": "narrow-face",
        "name": "Narrow face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/narrow-face"
      },
      {
        "slug": "lacrimal-duct-stenosis",
        "name": "Narrowing of the tear duct",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/lacrimal-duct-stenosis"
      },
      {
        "slug": "preauricular-pit",
        "name": "Pit in front of the ear",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/preauricular-pit"
      },
      {
        "slug": "polycystic-kidney-dysplasia",
        "name": "Polycystic kidney dysplasia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/polycystic-kidney-dysplasia"
      },
      {
        "slug": "retrognathia",
        "name": "Receding chin",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retrognathia"
      },
      {
        "slug": "renal-dysplasia",
        "name": "Renal dysplasia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-dysplasia"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "preauricular-skin-tag",
        "name": "Skin tag in front of the ear",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/preauricular-skin-tag"
      },
      {
        "slug": "microtia",
        "name": "Small ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/microtia"
      },
      {
        "slug": "ureteropelvic-junction-obstruction",
        "name": "Ureteropelvic junction obstruction",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ureteropelvic-junction-obstruction"
      },
      {
        "slug": "vesicoureteral-reflux",
        "name": "Vesicoureteral reflux",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vesicoureteral-reflux"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/actg1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/atp2b2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/cd164"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/ceacam16"
      },
      {
        "slug": "coch",
        "symbol": "COCH",
        "name": "cochlin",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/coch"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "name": "collagen type XI alpha 1 chain",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/col11a1"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "name": "collagen type XI alpha 2 chain",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/col11a2"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "name": "diaphanous related formin 1",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/diaph1"
      },
      {
        "slug": "eya4",
        "symbol": "EYA4",
        "name": "EYA transcriptional coactivator and phosphatase 4",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/eya4"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "name": "gap junction protein beta 2",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "name": "gap junction protein beta 6",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/gjb6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}