{
  "url": "https://dantelabs.com/nl/genes/rbbp7",
  "gene": {
    "slug": "rbbp7",
    "symbol": "RBBP7",
    "name": "RB binding protein 7, chromatin remodeling factor",
    "hgnc": "HGNC:9890",
    "summary": null,
    "location": "Xp22.2",
    "locusType": "gene with protein product",
    "aliases": [
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    "previousSymbols": [],
    "ensemblId": "ENSG00000102054",
    "entrezId": 5931,
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      "300825"
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    "uniprot": [
      "Q16576"
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    "model": {
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      "release": "v1.5",
      "chrom": "X",
      "start": 16844341,
      "end": 16870362,
      "strand": "-",
      "ensemblTranscript": "ENST00000380087.7",
      "refseqTranscript": "NM_002893.4",
      "ensemblProtein": "ENSP00000369427.3",
      "refseqProtein": "NP_002884.1",
      "exons": [
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
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      "end": 16888537,
      "strand": "-"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "CTPS2",
          "ensemblId": "ENSG00000047230",
          "biotype": "protein_coding",
          "start": 16580088,
          "end": 16712984,
          "strand": "-",
          "slug": "ctps2"
        },
        {
          "symbol": "S100G",
          "ensemblId": "ENSG00000169906",
          "biotype": "protein_coding",
          "start": 16650158,
          "end": 16654670,
          "strand": "+",
          "slug": "s100g"
        },
        {
          "symbol": "SYAP1",
          "ensemblId": "ENSG00000169895",
          "biotype": "protein_coding",
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        {
          "symbol": "TXLNG",
          "ensemblId": "ENSG00000086712",
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        {
          "symbol": "REPS2",
          "ensemblId": "ENSG00000169891",
          "biotype": "protein_coding",
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          "end": 17187961,
          "strand": "+",
          "slug": "reps2"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "decreased-serum-testosterone-concentration",
        "name": "Decreased serum testosterone level",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-serum-testosterone-concentration"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "elevated-circulating-follicle-stimulating-hormone-level",
        "name": "Elevated circulating follicle stimulating hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-follicle-stimulating-hormone-level"
      },
      {
        "slug": "elevated-circulating-luteinizing-hormone-level",
        "name": "Elevated circulating luteinizing hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-luteinizing-hormone-level"
      },
      {
        "slug": "increased-circulating-gonadotropin-level",
        "name": "Increased circulating gonadotropin level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-gonadotropin-level"
      },
      {
        "slug": "leydig-cell-neoplasia",
        "name": "Leydig cell neoplasia",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/leydig-cell-neoplasia"
      },
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-infertility"
      },
      {
        "slug": "non-obstructive-azoospermia",
        "name": "Non-obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/non-obstructive-azoospermia"
      },
      {
        "slug": "obstructive-azoospermia",
        "name": "Obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/obstructive-azoospermia"
      },
      {
        "slug": "spermatogenesis-maturation-arrest",
        "name": "Spermatogenesis maturation arrest",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/spermatogenesis-maturation-arrest"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}