{
  "url": "https://dantelabs.com/nl/genes/rac2",
  "gene": {
    "slug": "rac2",
    "symbol": "RAC2",
    "name": "Rac family small GTPase 2",
    "hgnc": "HGNC:9802",
    "summary": null,
    "location": "22q13.1",
    "locusType": "gene with protein product",
    "aliases": [
      "EN-7"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000128340",
    "entrezId": 5880,
    "omim": [
      "602049"
    ],
    "uniprot": [
      "P15153"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "22",
      "start": 37225270,
      "end": 37244269,
      "strand": "-",
      "ensemblTranscript": "ENST00000249071.11",
      "refseqTranscript": "NM_002872.5",
      "ensemblProtein": "ENSP00000249071.6",
      "refseqProtein": "NP_002863.1",
      "exons": [
        {
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        },
        {
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        {
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      ],
      "cds": {
        "start": 37226673,
        "end": 37244148
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "22",
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      "end": 37640488,
      "strand": "-"
    },
    "neighbourhood": {
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      "end": 37734769,
      "genes": [
        {
          "symbol": "IFT27",
          "ensemblId": "ENSG00000100360",
          "biotype": "protein_coding",
          "start": 36741346,
          "end": 36776309,
          "strand": "-",
          "slug": "ift27"
        },
        {
          "symbol": "PVALB",
          "ensemblId": "ENSG00000100362",
          "biotype": "protein_coding",
          "start": 36800682,
          "end": 36819479,
          "strand": "-",
          "slug": "pvalb"
        },
        {
          "symbol": "NCF4",
          "ensemblId": "ENSG00000100365",
          "biotype": "protein_coding",
          "start": 36860795,
          "end": 36878067,
          "strand": "+",
          "slug": "ncf4"
        },
        {
          "symbol": "CSF2RB",
          "ensemblId": "ENSG00000100368",
          "biotype": "protein_coding",
          "start": 36913590,
          "end": 36940454,
          "strand": "+",
          "slug": "csf2rb"
        },
        {
          "symbol": "CIMIP4",
          "ensemblId": "ENSG00000185264",
          "biotype": "protein_coding",
          "start": 36991119,
          "end": 37007884,
          "strand": "-",
          "slug": "cimip4"
        },
        {
          "symbol": "TST",
          "ensemblId": "ENSG00000128311",
          "biotype": "protein_coding",
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          "end": 37024797,
          "strand": "-",
          "slug": "tst"
        },
        {
          "symbol": "MPST",
          "ensemblId": "ENSG00000128309",
          "biotype": "protein_coding",
          "start": 37019635,
          "end": 37029828,
          "strand": "+",
          "slug": "mpst"
        },
        {
          "symbol": "KCTD17",
          "ensemblId": "ENSG00000100379",
          "biotype": "protein_coding",
          "start": 37051705,
          "end": 37063390,
          "strand": "+",
          "slug": "kctd17"
        },
        {
          "symbol": "TMPRSS6",
          "ensemblId": "ENSG00000187045",
          "biotype": "protein_coding",
          "start": 37065005,
          "end": 37110890,
          "strand": "-",
          "slug": "tmprss6"
        },
        {
          "symbol": "IL2RB",
          "ensemblId": "ENSG00000100385",
          "biotype": "protein_coding",
          "start": 37118666,
          "end": 37176676,
          "strand": "-",
          "slug": "il2rb"
        },
        {
          "symbol": "C1QTNF6",
          "ensemblId": "ENSG00000133466",
          "biotype": "protein_coding",
          "start": 37180166,
          "end": 37199385,
          "strand": "-",
          "slug": "c1qtnf6"
        },
        {
          "symbol": "SSTR3",
          "ensemblId": "ENSG00000278195",
          "biotype": "protein_coding",
          "start": 37204237,
          "end": 37212482,
          "strand": "-",
          "slug": "sstr3"
        },
        {
          "symbol": "CYTH4",
          "ensemblId": "ENSG00000100055",
          "biotype": "protein_coding",
          "start": 37282027,
          "end": 37315346,
          "strand": "+",
          "slug": "cyth4"
        },
        {
          "symbol": "ELFN2",
          "ensemblId": "ENSG00000166897",
          "biotype": "protein_coding",
          "start": 37367960,
          "end": 37427596,
          "strand": "-",
          "slug": "elfn2"
        },
        {
          "symbol": "MFNG",
          "ensemblId": "ENSG00000100060",
          "biotype": "protein_coding",
          "start": 37464544,
          "end": 37486432,
          "strand": "-",
          "slug": "mfng"
        },
        {
          "symbol": "CARD10",
          "ensemblId": "ENSG00000100065",
          "biotype": "protein_coding",
          "start": 37490362,
          "end": 37519591,
          "strand": "-",
          "slug": "card10"
        },
        {
          "symbol": "CDC42EP1",
          "ensemblId": "ENSG00000128283",
          "biotype": "protein_coding",
          "start": 37555112,
          "end": 37571052,
          "strand": "+",
          "slug": "cdc42ep1"
        },
        {
          "symbol": "LGALS2",
          "ensemblId": "ENSG00000100079",
          "biotype": "protein_coding",
          "start": 37570246,
          "end": 37582616,
          "strand": "-",
          "slug": "lgals2"
        },
        {
          "symbol": "GGA1",
          "ensemblId": "ENSG00000100083",
          "biotype": "protein_coding",
          "start": 37608474,
          "end": 37633564,
          "strand": "+",
          "slug": "gga1"
        },
        {
          "symbol": "SH3BP1",
          "ensemblId": "ENSG00000100092",
          "biotype": "protein_coding",
          "start": 37634654,
          "end": 37656117,
          "strand": "+",
          "slug": "sh3bp1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285304",
          "biotype": "protein_coding",
          "start": 37639693,
          "end": 37666932,
          "strand": "+"
        },
        {
          "symbol": "PDXP",
          "ensemblId": "ENSG00000241360",
          "biotype": "protein_coding",
          "start": 37658715,
          "end": 37666934,
          "strand": "+",
          "slug": "pdxp"
        },
        {
          "symbol": "LGALS1",
          "ensemblId": "ENSG00000100097",
          "biotype": "protein_coding",
          "start": 37675587,
          "end": 37683414,
          "strand": "+",
          "slug": "lgals1"
        },
        {
          "symbol": "NOL12",
          "ensemblId": "ENSG00000273899",
          "biotype": "protein_coding",
          "start": 37681673,
          "end": 37693476,
          "strand": "+",
          "slug": "nol12"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000100101",
          "biotype": "protein_coding",
          "start": 37686414,
          "end": 37726503,
          "strand": "+"
        },
        {
          "symbol": "TRIOBP",
          "ensemblId": "ENSG00000100106",
          "biotype": "protein_coding",
          "start": 37696983,
          "end": 37776581,
          "strand": "+",
          "slug": "triobp"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "severe-combined-immunodeficiency",
        "name": "Ernstige gecombineerde immuundeficiëntie",
        "diseases": [
          {
            "mondoId": "MONDO:0015974",
            "name": "Ernstige gecombineerde immuundeficiëntie",
            "genes": 31,
            "inheritance": "autosomal-recessive",
            "description": "Ernstige gecombineerde immuundeficiëntie (SCID) omvat een groep zeldzame monogene primaire immuundeficiëntieziekten die worden gekenmerkt door een gebrek aan functionele perifere T-lymfocyten, wat leidt tot ernstige luchtweginfecties die al vroeg in het leven optreden en tot een achterblijvende groei. Ze worden naar immunologisch fenotype ingedeeld in SCID met afwezigheid van T-cellen maar aanwezigheid van B-cellen (T-B+ SCID) of SCID met afwezigheid van beide (T-B- SCID). Beide groepen omvatten verschillende vormen, met of zonder natural killer (NK)-cellen.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/severe-combined-immunodeficiency"
      },
      {
        "slug": "immunodeficiency-disease",
        "name": "Overige aangeboren immuunstoornissen",
        "diseases": [
          {
            "mondoId": "MONDO:0021094",
            "name": "Immuundeficiëntieziekte",
            "genes": 170,
            "inheritance": null,
            "description": "Ziekte waarbij er een tekort of defect is in de mechanismen van de immuniteit, zowel cellulair als humoraal.",
            "management": "HSCT bij SCID en ernstige PID's; immunoglobulinevervangende therapie (IVIG/SCIG) bij antilichaamdeficiënties; leniolisib (Joenja, FDA 2023) bij APDS; genetherapie bij ADA-SCID; abatacept bij CTLA4- of LRBA-deficiëntie; profylactische antibiotica; G-CSF bij CGD",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/immunodeficiency-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-neutrophil-physiology",
        "name": "Abnormal neutrophil physiology",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-neutrophil-physiology"
      },
      {
        "slug": "abnormally-low-t-cell-receptor-excision-circle-level",
        "name": "Abnormally low T cell receptor excision circle level",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormally-low-t-cell-receptor-excision-circle-level"
      },
      {
        "slug": "cellulitis",
        "name": "Bacterial infection of skin",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cellulitis"
      },
      {
        "slug": "chronic-bronchitis",
        "name": "Chronic bronchitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/chronic-bronchitis"
      },
      {
        "slug": "chronic-pulmonary-obstruction",
        "name": "Chronic pulmonary obstruction",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/chronic-pulmonary-obstruction"
      },
      {
        "slug": "decreased-anti-cd3-28-induced-t-cell-proliferation",
        "name": "Decreased anti-CD3/28-induced T-cell proliferation",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-anti-cd3-28-induced-t-cell-proliferation"
      },
      {
        "slug": "decreased-total-leukocyte-count",
        "name": "Decreased blood leukocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-total-leukocyte-count"
      },
      {
        "slug": "decreased-total-lymphocyte-count",
        "name": "Decreased blood lymphocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-lymphocyte-count"
      },
      {
        "slug": "decreased-circulating-igg-concentration",
        "name": "Decreased circulating IgG concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-igg-concentration"
      },
      {
        "slug": "decreased-circulating-igm-concentration",
        "name": "Decreased circulating IgM concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-igm-concentration"
      },
      {
        "slug": "immunodeficiency",
        "name": "Decreased immune function",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/immunodeficiency"
      },
      {
        "slug": "decreased-neutrophil-oxidative-burst",
        "name": "Decreased neutrophil oxidative burst",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-neutrophil-oxidative-burst"
      },
      {
        "slug": "delayed-umbilical-cord-separation",
        "name": "Delayed umbilical cord separation",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-umbilical-cord-separation"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "hepatosplenomegaly",
        "name": "Enlarged liver and spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hepatosplenomegaly"
      },
      {
        "slug": "failure-to-thrive-in-infancy",
        "name": "Faltering weight in infancy",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/failure-to-thrive-in-infancy"
      },
      {
        "slug": "generalized-lymphadenopathy",
        "name": "Generalized swelling of lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/generalized-lymphadenopathy"
      },
      {
        "slug": "urticaria",
        "name": "Hives",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/urticaria"
      },
      {
        "slug": "impaired-neutrophil-chemotaxis",
        "name": "Impaired neutrophil chemotaxis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/impaired-neutrophil-chemotaxis"
      },
      {
        "slug": "increased-total-neutrophil-count",
        "name": "Increased blood neutrophil counts",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-total-neutrophil-count"
      },
      {
        "slug": "sepsis",
        "name": "Infection in blood stream",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sepsis"
      },
      {
        "slug": "lymphadenitis",
        "name": "Inflammation of the lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/lymphadenitis"
      },
      {
        "slug": "decreased-total-b-cell-count",
        "name": "Low B cell count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-b-cell-count"
      },
      {
        "slug": "pancytopenia",
        "name": "Low blood cell count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pancytopenia"
      },
      {
        "slug": "decreased-total-monocyte-count",
        "name": "Low blood monocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-total-monocyte-count"
      },
      {
        "slug": "decreased-total-neutrophil-count",
        "name": "Low blood neutrophil count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-neutrophil-count"
      },
      {
        "slug": "decreased-total-t-cell-count",
        "name": "Low T cell count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-t-cell-count"
      },
      {
        "slug": "macrocytic-anemia",
        "name": "Macrocytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/macrocytic-anemia"
      },
      {
        "slug": "neonatal-omphalitis",
        "name": "Neonatal omphalitis",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/neonatal-omphalitis"
      },
      {
        "slug": "partial-absence-of-specific-antibody-response-to-protein-conjugated-haemophilus-influenzae-type-b-vaccine",
        "name": "Partial absence of specific antibody response to protein-conjugated Haemophilus influenzae type b vaccine",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/partial-absence-of-specific-antibody-response-to-protein-conjugated-haemophilus-influenzae-type-b-vaccine"
      },
      {
        "slug": "bronchiectasis",
        "name": "Permanent enlargement of the airways of the lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bronchiectasis"
      },
      {
        "slug": "poor-wound-healing",
        "name": "Poor wound healing",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/poor-wound-healing"
      },
      {
        "slug": "pulmonary-fibrosis",
        "name": "Pulmonary scarring",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pulmonary-fibrosis"
      },
      {
        "slug": "rectal-abscess",
        "name": "Rectal abscess",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/rectal-abscess"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      },
      {
        "slug": "recurrent-otitis-media",
        "name": "Recurrent middle ear infection",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-otitis-media"
      },
      {
        "slug": "recurrent-pneumonia",
        "name": "Recurrent pneumonia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-pneumonia"
      },
      {
        "slug": "recurrent-respiratory-infections",
        "name": "Recurrent respiratory infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-respiratory-infections"
      },
      {
        "slug": "recurrent-sinusitis",
        "name": "Recurrent sinus disease",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/recurrent-sinusitis"
      },
      {
        "slug": "reduction-of-neutrophil-motility",
        "name": "Reduction of neutrophil motility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduction-of-neutrophil-motility"
      },
      {
        "slug": "severe-varicella-zoster-infection",
        "name": "Severe varicella zoster infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/severe-varicella-zoster-infection"
      },
      {
        "slug": "cervical-lymphadenopathy",
        "name": "Swollen lymph nodes in the neck",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/cervical-lymphadenopathy"
      },
      {
        "slug": "urachal-cyst",
        "name": "Urachal cyst",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/urachal-cyst"
      }
    ],
    "related": [
      {
        "slug": "ada",
        "symbol": "ADA",
        "name": "adenosine deaminase",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/ada"
      },
      {
        "slug": "ak2",
        "symbol": "AK2",
        "name": "adenylate kinase 2",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/ak2"
      },
      {
        "slug": "bcl11b",
        "symbol": "BCL11B",
        "name": "BCL11 transcription factor B",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/bcl11b"
      },
      {
        "slug": "card11",
        "symbol": "CARD11",
        "name": "caspase recruitment domain family member 11",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/card11"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "name": "capping protein regulator and myosin 1 linker 2",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/carmil2"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "name": "CD247 molecule",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/cd247"
      },
      {
        "slug": "cd3d",
        "symbol": "CD3D",
        "name": "CD3 delta subunit of T-cell receptor complex",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/cd3d"
      },
      {
        "slug": "cd3e",
        "symbol": "CD3E",
        "name": "CD3 epsilon subunit of T-cell receptor complex",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/cd3e"
      },
      {
        "slug": "cd70",
        "symbol": "CD70",
        "name": "CD70 molecule",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/cd70"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "name": "class II major histocompatibility complex transactivator",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/ciita"
      },
      {
        "slug": "coro1a",
        "symbol": "CORO1A",
        "name": "coronin 1A",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/coro1a"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "name": "DNA cross-link repair 1C",
        "shared": 2,
        "url": "https://dantelabs.com/nl/genes/dclre1c"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-e609d43e",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}