{
  "url": "https://dantelabs.com/nl/genes/ptpn1",
  "gene": {
    "slug": "ptpn1",
    "symbol": "PTPN1",
    "name": "protein tyrosine phosphatase non-receptor type 1",
    "hgnc": "HGNC:9642",
    "summary": null,
    "location": "20q13.13",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "PTP1B"
    ],
    "ensemblId": "ENSG00000196396",
    "entrezId": 5770,
    "omim": [
      "176885"
    ],
    "uniprot": [
      "P18031"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "20",
      "start": 50510383,
      "end": 50585241,
      "strand": "+",
      "ensemblTranscript": "ENST00000371621.5",
      "refseqTranscript": "NM_002827.4",
      "ensemblProtein": "ENSP00000360683.3",
      "refseqProtein": "NP_002818.1",
      "exons": [
        {
          "start": 50510383,
          "end": 50510590
        },
        {
          "start": 50561363,
          "end": 50561453
        },
        {
          "start": 50564969,
          "end": 50565069
        },
        {
          "start": 50568380,
          "end": 50568478
        },
        {
          "start": 50574517,
          "end": 50574654
        },
        {
          "start": 50578420,
          "end": 50578629
        },
        {
          "start": 50579168,
          "end": 50579329
        },
        {
          "start": 50579703,
          "end": 50579926
        },
        {
          "start": 50581265,
          "end": 50581460
        },
        {
          "start": 50582692,
          "end": 50585241
        }
      ],
      "cds": {
        "start": 50510528,
        "end": 50582715
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "20",
      "start": 49126891,
      "end": 49201299,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 50047812,
      "end": 51047811,
      "genes": [
        {
          "symbol": "UBE2V1",
          "ensemblId": "ENSG00000244687",
          "biotype": "protein_coding",
          "start": 50081122,
          "end": 50115959,
          "strand": "-",
          "slug": "ube2v1"
        },
        {
          "symbol": "PEDS1-UBE2V1",
          "ensemblId": "ENSG00000124208",
          "biotype": "protein_coding",
          "start": 50081124,
          "end": 50153637,
          "strand": "-",
          "slug": "peds1-ube2v1"
        },
        {
          "symbol": "PEDS1",
          "ensemblId": "ENSG00000240849",
          "biotype": "protein_coding",
          "start": 50118254,
          "end": 50153754,
          "strand": "-",
          "slug": "peds1"
        },
        {
          "symbol": "CEBPB",
          "ensemblId": "ENSG00000172216",
          "biotype": "protein_coding",
          "start": 50190734,
          "end": 50192690,
          "strand": "+",
          "slug": "cebpb"
        },
        {
          "symbol": "RIPOR3",
          "ensemblId": "ENSG00000042062",
          "biotype": "protein_coding",
          "start": 50585180,
          "end": 50692021,
          "strand": "-",
          "slug": "ripor3"
        },
        {
          "symbol": "PARD6B",
          "ensemblId": "ENSG00000124171",
          "biotype": "protein_coding",
          "start": 50731365,
          "end": 50756836,
          "strand": "+",
          "slug": "pard6b"
        },
        {
          "symbol": "BCAS4",
          "ensemblId": "ENSG00000124243",
          "biotype": "protein_coding",
          "start": 50794894,
          "end": 50877179,
          "strand": "+",
          "slug": "bcas4"
        },
        {
          "symbol": "ADNP",
          "ensemblId": "ENSG00000101126",
          "biotype": "protein_coding",
          "start": 50854048,
          "end": 50931437,
          "strand": "-",
          "slug": "adnp"
        },
        {
          "symbol": "DPM1",
          "ensemblId": "ENSG00000000419",
          "biotype": "protein_coding",
          "start": 50932897,
          "end": 50959145,
          "strand": "-",
          "slug": "dpm1"
        },
        {
          "symbol": "MOCS3",
          "ensemblId": "ENSG00000124217",
          "biotype": "protein_coding",
          "start": 50958818,
          "end": 50963929,
          "strand": "+",
          "slug": "mocs3"
        },
        {
          "symbol": "KCNG1",
          "ensemblId": "ENSG00000026559",
          "biotype": "protein_coding",
          "start": 51003655,
          "end": 51023244,
          "strand": "-",
          "slug": "kcng1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "insulin-resistance",
        "name": "Body fails to respond to insulin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/insulin-resistance"
      },
      {
        "slug": "increased-waist-to-hip-ratio",
        "name": "Increased waist to hip ratio",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/increased-waist-to-hip-ratio"
      },
      {
        "slug": "type-ii-diabetes-mellitus",
        "name": "Noninsulin-dependent diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/type-ii-diabetes-mellitus"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}