{
  "url": "https://dantelabs.com/nl/genes/nanos1",
  "gene": {
    "slug": "nanos1",
    "symbol": "NANOS1",
    "name": "nanos C2HC-type zinc finger 1",
    "hgnc": "HGNC:23044",
    "summary": null,
    "location": "10q26.11",
    "locusType": "gene with protein product",
    "aliases": [
      "NOS1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000188613",
    "entrezId": 340719,
    "omim": [
      "608226"
    ],
    "uniprot": [
      "Q8WY41"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 119029714,
      "end": 119033730,
      "strand": "+",
      "ensemblTranscript": "ENST00000425699.3",
      "refseqTranscript": "NM_199461.4",
      "ensemblProtein": "ENSP00000393275.1",
      "refseqProtein": "NP_955631.1",
      "exons": [
        {
          "start": 119029714,
          "end": 119033730
        }
      ],
      "cds": {
        "start": 119029802,
        "end": 119030680
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 120789228,
      "end": 120793854,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 118531722,
      "end": 119531721,
      "genes": [
        {
          "symbol": "PRLHR",
          "ensemblId": "ENSG00000119973",
          "biotype": "protein_coding",
          "start": 118589997,
          "end": 118596704,
          "strand": "-",
          "slug": "prlhr"
        },
        {
          "symbol": "CACUL1",
          "ensemblId": "ENSG00000151893",
          "biotype": "protein_coding",
          "start": 118672231,
          "end": 118755249,
          "strand": "-",
          "slug": "cacul1"
        },
        {
          "symbol": "EIF3A",
          "ensemblId": "ENSG00000107581",
          "biotype": "protein_coding",
          "start": 119033670,
          "end": 119080867,
          "strand": "-",
          "slug": "eif3a"
        },
        {
          "symbol": "DENND10",
          "ensemblId": "ENSG00000119979",
          "biotype": "protein_coding",
          "start": 119104052,
          "end": 119137986,
          "strand": "+",
          "slug": "dennd10"
        },
        {
          "symbol": "SFXN4",
          "ensemblId": "ENSG00000183605",
          "biotype": "protein_coding",
          "start": 119120955,
          "end": 119165724,
          "strand": "-",
          "slug": "sfxn4"
        },
        {
          "symbol": "PRDX3",
          "ensemblId": "ENSG00000165672",
          "biotype": "protein_coding",
          "start": 119167699,
          "end": 119178865,
          "strand": "-",
          "slug": "prdx3"
        },
        {
          "symbol": "GRK5",
          "ensemblId": "ENSG00000198873",
          "biotype": "protein_coding",
          "start": 119207538,
          "end": 119459758,
          "strand": "+",
          "slug": "grk5"
        },
        {
          "symbol": "RGS10",
          "ensemblId": "ENSG00000148908",
          "biotype": "protein_coding",
          "start": 119499603,
          "end": 119543620,
          "strand": "-",
          "slug": "rgs10"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-male-germ-cell-morphology",
        "name": "Abnormal male germ cell morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-male-germ-cell-morphology"
      },
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "increased-circulating-gonadotropin-level",
        "name": "Increased circulating gonadotropin level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-gonadotropin-level"
      },
      {
        "slug": "infertility",
        "name": "Infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/infertility"
      },
      {
        "slug": "non-obstructive-azoospermia",
        "name": "Non-obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/non-obstructive-azoospermia"
      },
      {
        "slug": "obstructive-azoospermia",
        "name": "Obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/obstructive-azoospermia"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}