{
  "url": "https://dantelabs.com/nl/genes/mylk3",
  "gene": {
    "slug": "mylk3",
    "symbol": "MYLK3",
    "name": "myosin light chain kinase 3",
    "hgnc": "HGNC:29826",
    "summary": null,
    "location": "16q11.2",
    "locusType": "gene with protein product",
    "aliases": [
      "caMLCK",
      "MLCK"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000140795",
    "entrezId": 91807,
    "omim": [
      "612147"
    ],
    "uniprot": [
      "Q32MK0"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "16",
      "start": 46702282,
      "end": 46748344,
      "strand": "-",
      "ensemblTranscript": "ENST00000394809.9",
      "refseqTranscript": "NM_182493.3",
      "ensemblProtein": "ENSP00000378288.4",
      "refseqProtein": "NP_872299.2",
      "exons": [
        {
          "start": 46702282,
          "end": 46707763
        },
        {
          "start": 46709539,
          "end": 46709671
        },
        {
          "start": 46710637,
          "end": 46710789
        },
        {
          "start": 46712648,
          "end": 46712776
        },
        {
          "start": 46721123,
          "end": 46721193
        },
        {
          "start": 46727236,
          "end": 46727377
        },
        {
          "start": 46729024,
          "end": 46729133
        },
        {
          "start": 46729594,
          "end": 46729687
        },
        {
          "start": 46730593,
          "end": 46730698
        },
        {
          "start": 46732208,
          "end": 46732668
        },
        {
          "start": 46737711,
          "end": 46738143
        },
        {
          "start": 46740057,
          "end": 46740147
        },
        {
          "start": 46747717,
          "end": 46748344
        }
      ],
      "cds": {
        "start": 46707704,
        "end": 46748193
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "16",
      "start": 46740891,
      "end": 46824319,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 46225313,
      "end": 47225312,
      "genes": [
        {
          "symbol": "SHCBP1",
          "ensemblId": "ENSG00000171241",
          "biotype": "protein_coding",
          "start": 46578565,
          "end": 46621404,
          "strand": "-",
          "slug": "shcbp1"
        },
        {
          "symbol": "VPS35",
          "ensemblId": "ENSG00000069329",
          "biotype": "protein_coding",
          "start": 46656132,
          "end": 46689518,
          "strand": "-",
          "slug": "vps35"
        },
        {
          "symbol": "ORC6",
          "ensemblId": "ENSG00000091651",
          "biotype": "protein_coding",
          "start": 46689301,
          "end": 46698399,
          "strand": "+",
          "slug": "orc6"
        },
        {
          "symbol": "HDIP1",
          "ensemblId": "ENSG00000155330",
          "biotype": "protein_coding",
          "start": 46796603,
          "end": 46831476,
          "strand": "-",
          "slug": "hdip1"
        },
        {
          "symbol": "GPT2",
          "ensemblId": "ENSG00000166123",
          "biotype": "protein_coding",
          "start": 46882857,
          "end": 46931299,
          "strand": "+",
          "slug": "gpt2"
        },
        {
          "symbol": "DNAJA2",
          "ensemblId": "ENSG00000069345",
          "biotype": "protein_coding",
          "start": 46955362,
          "end": 46973709,
          "strand": "-",
          "slug": "dnaja2"
        },
        {
          "symbol": "NETO2",
          "ensemblId": "ENSG00000171208",
          "biotype": "protein_coding",
          "start": 47077703,
          "end": 47144028,
          "strand": "-",
          "slug": "neto2"
        },
        {
          "symbol": "ITFG1",
          "ensemblId": "ENSG00000129636",
          "biotype": "protein_coding",
          "start": 47154387,
          "end": 47464149,
          "strand": "-",
          "slug": "itfg1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "dilated-cardiomyopathy",
        "name": "Dilaterende cardiomyopathie",
        "diseases": [
          {
            "mondoId": "MONDO:0005021",
            "name": "Dilaterende cardiomyopathie",
            "genes": 50,
            "inheritance": null,
            "description": "Vergroting en verzwakking van de linkerventrikel die niet verklaard wordt door coronaire hartziekte of kleplijden; erfelijke vormen betreffen TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN en vele andere genen, en omvatten het syndroom van Barth en de spierdystrofieën van Emery-Dreifuss.",
            "management": "Het kennen van een genetische oorzaak ondersteunt eerdere hartcontroles en screening van familieleden, en voor genen met een hoog aritmierisico, zoals LMNA, FLNC en RBM20, helpt het bij beslissingen over ritmebewaking en implanteerbare defibrillatoren.",
            "evidence": {
              "gencc": [],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/dilated-cardiomyopathy"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "name": "ATP binding cassette subfamily C member 9",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/abcc9"
      },
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "name": "actin alpha cardiac muscle 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/actc1"
      },
      {
        "slug": "bag3",
        "symbol": "BAG3",
        "name": "BAG cochaperone 3",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/bag3"
      },
      {
        "slug": "bag5",
        "symbol": "BAG5",
        "name": "BAG cochaperone 5",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/bag5"
      },
      {
        "slug": "des",
        "symbol": "DES",
        "name": "desmin",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/des"
      },
      {
        "slug": "dmd",
        "symbol": "DMD",
        "name": "dystrophin",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/dmd"
      },
      {
        "slug": "dolk",
        "symbol": "DOLK",
        "name": "dolichol kinase",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/dolk"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "name": "emerin",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/emd"
      },
      {
        "slug": "fhl1",
        "symbol": "FHL1",
        "name": "four and a half LIM domains 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/fhl1"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "name": "fukutin",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/fktn"
      },
      {
        "slug": "flii",
        "symbol": "FLII",
        "name": "FLII actin remodeling protein",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/flii"
      },
      {
        "slug": "flnc",
        "symbol": "FLNC",
        "name": "filamin C",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/flnc"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}