{
  "url": "https://dantelabs.com/nl/genes/lars2",
  "gene": {
    "slug": "lars2",
    "symbol": "LARS2",
    "name": "leucyl-tRNA synthetase 2, mitochondrial",
    "hgnc": "HGNC:17095",
    "summary": null,
    "location": "3p21.31",
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      "mtLeuRS"
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      "Q15031"
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      "release": "v1.5",
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      "strand": "+",
      "ensemblTranscript": "ENST00000645846.2",
      "refseqTranscript": "NM_015340.4",
      "ensemblProtein": "ENSP00000495093.1",
      "refseqProtein": "NP_056155.1",
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        "end": 45547530
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
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      "end": 45590913,
      "strand": "+"
    },
    "neighbourhood": {
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        {
          "symbol": "ZDHHC3",
          "ensemblId": "ENSG00000163812",
          "biotype": "protein_coding",
          "start": 44914692,
          "end": 44976282,
          "strand": "-",
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        {
          "symbol": "EXOSC7",
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          "biotype": "protein_coding",
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          "end": 45036071,
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          "slug": "exosc7"
        },
        {
          "symbol": "CLEC3B",
          "ensemblId": "ENSG00000163815",
          "biotype": "protein_coding",
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          "end": 45036071,
          "strand": "+",
          "slug": "clec3b"
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        {
          "symbol": "CDCP1",
          "ensemblId": "ENSG00000163814",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "cdcp1"
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        {
          "symbol": "TMEM158",
          "ensemblId": "ENSG00000249992",
          "biotype": "protein_coding",
          "start": 45224466,
          "end": 45226287,
          "strand": "-",
          "slug": "tmem158"
        },
        {
          "symbol": "LIMD1",
          "ensemblId": "ENSG00000144791",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "limd1"
        },
        {
          "symbol": "SACM1L",
          "ensemblId": "ENSG00000211456",
          "biotype": "protein_coding",
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          "end": 45745425,
          "strand": "+",
          "slug": "sacm1l"
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        {
          "symbol": "SLC6A20",
          "ensemblId": "ENSG00000163817",
          "biotype": "protein_coding",
          "start": 45748903,
          "end": 45796654,
          "strand": "-",
          "slug": "slc6a20"
        },
        {
          "symbol": "LZTFL1",
          "ensemblId": "ENSG00000163818",
          "biotype": "protein_coding",
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          "end": 45916042,
          "strand": "-",
          "slug": "lztfl1"
        },
        {
          "symbol": "CCR9",
          "ensemblId": "ENSG00000173585",
          "biotype": "protein_coding",
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          "end": 45904311,
          "strand": "+",
          "slug": "ccr9"
        },
        {
          "symbol": "FYCO1",
          "ensemblId": "ENSG00000163820",
          "biotype": "protein_coding",
          "start": 45917903,
          "end": 45995845,
          "strand": "-",
          "slug": "fyco1"
        },
        {
          "symbol": "CXCR6",
          "ensemblId": "ENSG00000172215",
          "biotype": "protein_coding",
          "start": 45940915,
          "end": 45948640,
          "strand": "+",
          "slug": "cxcr6"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "female-infertility",
        "name": "Vrouwelijke onvruchtbaarheid",
        "diseases": [
          {
            "mondoId": "MONDO:0021124",
            "name": "Vrouwelijke onvruchtbaarheid",
            "genes": 37,
            "inheritance": null,
            "description": "Verminderd of afwezig vermogen van een vrouw om zwanger te worden.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/female-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "ascites",
        "name": "Accumulation of fluid in the abdomen",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ascites"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cleft-palate"
      },
      {
        "slug": "cognitive-impairment",
        "name": "Cognitive impairment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cognitive-impairment"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "decreased-liver-function",
        "name": "Decreased liver function",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-liver-function"
      },
      {
        "slug": "decreased-serum-estradiol",
        "name": "Decreased serum estradiol",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-serum-estradiol"
      },
      {
        "slug": "disproportionate-tall-stature",
        "name": "Disproportionate tall stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/disproportionate-tall-stature"
      },
      {
        "slug": "premature-ovarian-insufficiency",
        "name": "Early menopause",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/premature-ovarian-insufficiency"
      },
      {
        "slug": "eeg-abnormality",
        "name": "EEG abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/eeg-abnormality"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "erythroid-hyperplasia",
        "name": "Erythroid hyperplasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/erythroid-hyperplasia"
      },
      {
        "slug": "extramedullary-hematopoiesis",
        "name": "Extramedullary hematopoiesis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/extramedullary-hematopoiesis"
      },
      {
        "slug": "fetal-pericardial-effusion",
        "name": "Fetal pericardial effusion",
        "systems": [
          "abnormality-of-prenatal-development-or-birth",
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fetal-pericardial-effusion"
      },
      {
        "slug": "bicornuate-uterus",
        "name": "Heart shaped uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bicornuate-uterus"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "increased-circulating-lactate-concentration",
        "name": "Higher than normal levels of lactate in blood",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-lactate-concentration"
      },
      {
        "slug": "ventricular-septal-defect",
        "name": "Hole in heart wall separating two lower heart chambers",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ventricular-septal-defect"
      },
      {
        "slug": "gait-ataxia",
        "name": "Inability to coordinate movements when walking",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gait-ataxia"
      },
      {
        "slug": "pulmonary-arterial-hypertension",
        "name": "Increased blood pressure in blood vessels of lungs",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pulmonary-arterial-hypertension"
      },
      {
        "slug": "increased-circulating-gonadotropin-level",
        "name": "Increased circulating gonadotropin level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-gonadotropin-level"
      },
      {
        "slug": "lactic-acidosis",
        "name": "Increased lactate in body",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/lactic-acidosis"
      },
      {
        "slug": "increased-mean-corpuscular-volume",
        "name": "Increased mean corpuscular volume",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-mean-corpuscular-volume"
      },
      {
        "slug": "oligomenorrhea",
        "name": "Light or infrequent menstrual periods",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligomenorrhea"
      },
      {
        "slug": "hypoalbuminemia",
        "name": "Low albumin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypoalbuminemia"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "thrombocytopenia",
        "name": "Low platelet count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/thrombocytopenia"
      },
      {
        "slug": "metabolic-acidosis",
        "name": "Metabolic acidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/metabolic-acidosis"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "nonimmune-hydrops-fetalis",
        "name": "Nonimmune hydrops fetalis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/nonimmune-hydrops-fetalis"
      },
      {
        "slug": "obesity",
        "name": "Obesity",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/obesity"
      },
      {
        "slug": "osteoporosis",
        "name": "Osteoporosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/osteoporosis"
      },
      {
        "slug": "cubitus-valgus",
        "name": "Outward turned elbows",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cubitus-valgus"
      },
      {
        "slug": "overriding-aorta",
        "name": "Overriding aorta",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/overriding-aorta"
      },
      {
        "slug": "patent-ductus-arteriosus",
        "name": "Patent ductus arteriosus",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "secondary-amenorrhea",
        "name": "Previous menstrual periods stop",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/secondary-amenorrhea"
      },
      {
        "slug": "primary-amenorrhea",
        "name": "Primary amenorrhea",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/primary-amenorrhea"
      },
      {
        "slug": "progressive-sensorineural-hearing-impairment",
        "name": "Progressive sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/progressive-sensorineural-hearing-impairment"
      },
      {
        "slug": "respiratory-insufficiency",
        "name": "Respiratory function loss",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/respiratory-insufficiency"
      },
      {
        "slug": "second-degree-atrioventricular-block",
        "name": "Second degree atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/second-degree-atrioventricular-block"
      },
      {
        "slug": "sideroblastic-anemia",
        "name": "Sideroblastic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/sideroblastic-anemia"
      },
      {
        "slug": "small-for-gestational-age",
        "name": "Small for gestational age",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/small-for-gestational-age"
      },
      {
        "slug": "hypoplasia-of-the-uterus",
        "name": "Small uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-uterus"
      },
      {
        "slug": "tarlov-cyst",
        "name": "Tarlov cyst",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tarlov-cyst"
      },
      {
        "slug": "hypoplasia-of-the-ovary",
        "name": "Underdeveloped ovary",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-ovary"
      }
    ],
    "related": [
      {
        "slug": "ankrd31",
        "symbol": "ANKRD31",
        "name": "ankyrin repeat domain 31",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/ankrd31"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "name": "ATM serine/threonine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/atm"
      },
      {
        "slug": "bmp15",
        "symbol": "BMP15",
        "name": "bone morphogenetic protein 15",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/bmp15"
      },
      {
        "slug": "bnc1",
        "symbol": "BNC1",
        "name": "basonuclin zinc finger protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/bnc1"
      },
      {
        "slug": "clpp",
        "symbol": "CLPP",
        "name": "caseinolytic mitochondrial matrix peptidase proteolytic subunit",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/clpp"
      },
      {
        "slug": "cyp19a1",
        "symbol": "CYP19A1",
        "name": "cytochrome P450 family 19 subfamily A member 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/cyp19a1"
      },
      {
        "slug": "fancm",
        "symbol": "FANCM",
        "name": "FA complementation group M",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/fancm"
      },
      {
        "slug": "figla",
        "symbol": "FIGLA",
        "name": "folliculogenesis specific bHLH transcription factor",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/figla"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "name": "fragile X messenger ribonucleoprotein 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/fmr1"
      },
      {
        "slug": "foxl2",
        "symbol": "FOXL2",
        "name": "forkhead box L2",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/foxl2"
      },
      {
        "slug": "fshr",
        "symbol": "FSHR",
        "name": "follicle stimulating hormone receptor",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/fshr"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "name": "galactose-1-phosphate uridylyltransferase",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/galt"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}