{
  "url": "https://dantelabs.com/nl/genes/kcne2",
  "gene": {
    "slug": "kcne2",
    "symbol": "KCNE2",
    "name": "potassium voltage-gated channel subfamily E regulatory subunit 2",
    "hgnc": "HGNC:6242",
    "summary": null,
    "location": "21q22.11",
    "locusType": "gene with protein product",
    "aliases": [
      "MiRP1",
      "LQT6"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000159197",
    "entrezId": 9992,
    "omim": [
      "603796"
    ],
    "uniprot": [
      "Q9Y6J6"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "21",
      "start": 34364006,
      "end": 34371381,
      "strand": "+",
      "ensemblTranscript": "ENST00000290310.4",
      "refseqTranscript": "NM_172201.2",
      "ensemblProtein": "ENSP00000290310.2",
      "refseqProtein": "NP_751951.1",
      "exons": [
        {
          "start": 34364006,
          "end": 34364151
        },
        {
          "start": 34370467,
          "end": 34371381
        }
      ],
      "cds": {
        "start": 34370479,
        "end": 34370850
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "21",
      "start": 35736323,
      "end": 35743688,
      "strand": "+"
    },
    "neighbourhood": {
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      "start": 33867694,
      "end": 34867693,
      "genes": [
        {
          "symbol": "",
          "ensemblId": "ENSG00000249209",
          "biotype": "protein_coding",
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          "end": 33931607,
          "strand": "-"
        },
        {
          "symbol": "ITSN1",
          "ensemblId": "ENSG00000205726",
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          "end": 33899861,
          "strand": "+",
          "slug": "itsn1"
        },
        {
          "symbol": "ATP5PO",
          "ensemblId": "ENSG00000241837",
          "biotype": "protein_coding",
          "start": 33901027,
          "end": 33915853,
          "strand": "-",
          "slug": "atp5po"
        },
        {
          "symbol": "MRPS6",
          "ensemblId": "ENSG00000243927",
          "biotype": "protein_coding",
          "start": 34072889,
          "end": 34362252,
          "strand": "+",
          "slug": "mrps6"
        },
        {
          "symbol": "SLC5A3",
          "ensemblId": "ENSG00000198743",
          "biotype": "protein_coding",
          "start": 34073509,
          "end": 34106260,
          "strand": "+",
          "slug": "slc5a3"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000293606",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "SMIM11",
          "ensemblId": "ENSG00000205670",
          "biotype": "protein_coding",
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          "end": 34416961,
          "strand": "+",
          "slug": "smim11"
        },
        {
          "symbol": "C21orf140",
          "ensemblId": "ENSG00000222018",
          "biotype": "protein_coding",
          "start": 34400112,
          "end": 34401072,
          "strand": "-",
          "slug": "c21orf140"
        },
        {
          "symbol": "SMIM34",
          "ensemblId": "ENSG00000243627",
          "biotype": "protein_coding",
          "start": 34414494,
          "end": 34423951,
          "strand": "-",
          "slug": "smim34"
        },
        {
          "symbol": "KCNE1",
          "ensemblId": "ENSG00000180509",
          "biotype": "protein_coding",
          "start": 34446688,
          "end": 34512214,
          "strand": "-",
          "slug": "kcne1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000288711",
          "biotype": "protein_coding",
          "start": 34511122,
          "end": 34614913,
          "strand": "-"
        },
        {
          "symbol": "RCAN1",
          "ensemblId": "ENSG00000159200",
          "biotype": "protein_coding",
          "start": 34513142,
          "end": 34615323,
          "strand": "-",
          "slug": "rcan1"
        },
        {
          "symbol": "CLIC6",
          "ensemblId": "ENSG00000159212",
          "biotype": "protein_coding",
          "start": 34668966,
          "end": 34718227,
          "strand": "+",
          "slug": "clic6"
        },
        {
          "symbol": "RUNX1",
          "ensemblId": "ENSG00000159216",
          "biotype": "protein_coding",
          "start": 34787801,
          "end": 36004667,
          "strand": "-",
          "slug": "runx1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "dyspnea",
        "name": "Breathing difficulty",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dyspnea"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "exercise-intolerance",
        "name": "Decreased ability to exercise",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/exercise-intolerance"
      },
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "myocardial-infarction",
        "name": "Heart attack",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myocardial-infarction"
      },
      {
        "slug": "cardiac-arrest",
        "name": "Heart stops beating",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cardiac-arrest"
      },
      {
        "slug": "palpitations",
        "name": "Palpitations",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/palpitations"
      },
      {
        "slug": "paroxysmal-atrial-fibrillation",
        "name": "Paroxysmal atrial fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paroxysmal-atrial-fibrillation"
      },
      {
        "slug": "permanent-atrial-fibrillation",
        "name": "Permanent atrial fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/permanent-atrial-fibrillation"
      },
      {
        "slug": "premature-atrial-contractions",
        "name": "Premature atrial contractions",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/premature-atrial-contractions"
      },
      {
        "slug": "prolonged-qt-interval",
        "name": "Prolonged QT interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/prolonged-qt-interval"
      },
      {
        "slug": "prolonged-qtc-interval",
        "name": "Prolonged QTc interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prolonged-qtc-interval"
      },
      {
        "slug": "atrial-fibrillation",
        "name": "Quivering upper heart chambers resulting in irregular heartbeat",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/atrial-fibrillation"
      },
      {
        "slug": "sudden-cardiac-death",
        "name": "Sudden cardiac death",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "constitutional-symptom"
        ],
        "url": "https://dantelabs.com/traits/sudden-cardiac-death"
      },
      {
        "slug": "thromboembolic-stroke",
        "name": "Thromboembolic stroke",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolic-stroke"
      },
      {
        "slug": "thromboembolism",
        "name": "Thromboembolism",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolism"
      },
      {
        "slug": "torsade-de-pointes",
        "name": "Torsade de pointes",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/torsade-de-pointes"
      },
      {
        "slug": "ventricular-fibrillation",
        "name": "Ventricular fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventricular-fibrillation"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}