{
  "url": "https://dantelabs.com/nl/genes/il36rn",
  "gene": {
    "slug": "il36rn",
    "symbol": "IL36RN",
    "name": "interleukin 36 receptor antagonist",
    "hgnc": "HGNC:15561",
    "summary": null,
    "location": "2q14.1",
    "locusType": "gene with protein product",
    "aliases": [
      "FIL1",
      "FIL1(DELTA)",
      "FIL1D",
      "IL1HY1",
      "IL1RP3",
      "IL1L1",
      "IL-1F5",
      "IL36RA",
      "MGC29840"
    ],
    "previousSymbols": [
      "IL1F5"
    ],
    "ensemblId": "ENSG00000136695",
    "entrezId": 26525,
    "omim": [
      "605507"
    ],
    "uniprot": [
      "Q9UBH0"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "2",
      "start": 113059198,
      "end": 113064744,
      "strand": "+",
      "ensemblTranscript": "ENST00000393200.7",
      "refseqTranscript": "NM_012275.3",
      "ensemblProtein": "ENSP00000376896.2",
      "refseqProtein": "NP_036407.1",
      "exons": [
        {
          "start": 113059198,
          "end": 113059241
        },
        {
          "start": 113059412,
          "end": 113059467
        },
        {
          "start": 113060852,
          "end": 113060937
        },
        {
          "start": 113062124,
          "end": 113062251
        },
        {
          "start": 113062453,
          "end": 113064744
        }
      ],
      "cds": {
        "start": 113059439,
        "end": 113062677
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "2",
      "start": 113816215,
      "end": 113822959,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 112561971,
      "end": 113561970,
      "genes": [
        {
          "symbol": "POLR1B",
          "ensemblId": "ENSG00000125630",
          "biotype": "protein_coding",
          "start": 112541915,
          "end": 112579818,
          "strand": "+",
          "slug": "polr1b"
        },
        {
          "symbol": "CHCHD5",
          "ensemblId": "ENSG00000125611",
          "biotype": "protein_coding",
          "start": 112584240,
          "end": 112589275,
          "strand": "+",
          "slug": "chchd5"
        },
        {
          "symbol": "SLC20A1",
          "ensemblId": "ENSG00000144136",
          "biotype": "protein_coding",
          "start": 112645853,
          "end": 112664727,
          "strand": "+",
          "slug": "slc20a1"
        },
        {
          "symbol": "NT5DC4",
          "ensemblId": "ENSG00000144130",
          "biotype": "protein_coding",
          "start": 112721020,
          "end": 112742879,
          "strand": "+",
          "slug": "nt5dc4"
        },
        {
          "symbol": "CKAP2L",
          "ensemblId": "ENSG00000169607",
          "biotype": "protein_coding",
          "start": 112736349,
          "end": 112764664,
          "strand": "-",
          "slug": "ckap2l"
        },
        {
          "symbol": "IL1A",
          "ensemblId": "ENSG00000115008",
          "biotype": "protein_coding",
          "start": 112773916,
          "end": 112784500,
          "strand": "-",
          "slug": "il1a"
        },
        {
          "symbol": "IL1B",
          "ensemblId": "ENSG00000125538",
          "biotype": "protein_coding",
          "start": 112829750,
          "end": 112864235,
          "strand": "-",
          "slug": "il1b"
        },
        {
          "symbol": "IL37",
          "ensemblId": "ENSG00000125571",
          "biotype": "protein_coding",
          "start": 112911160,
          "end": 112918882,
          "strand": "+",
          "slug": "il37"
        },
        {
          "symbol": "IL36G",
          "ensemblId": "ENSG00000136688",
          "biotype": "protein_coding",
          "start": 112973203,
          "end": 112985672,
          "strand": "+",
          "slug": "il36g"
        },
        {
          "symbol": "IL36A",
          "ensemblId": "ENSG00000136694",
          "biotype": "protein_coding",
          "start": 113005459,
          "end": 113008044,
          "strand": "+",
          "slug": "il36a"
        },
        {
          "symbol": "IL36B",
          "ensemblId": "ENSG00000136696",
          "biotype": "protein_coding",
          "start": 113022089,
          "end": 113052867,
          "strand": "-",
          "slug": "il36b"
        },
        {
          "symbol": "IL38",
          "ensemblId": "ENSG00000136697",
          "biotype": "protein_coding",
          "start": 113067970,
          "end": 113075843,
          "strand": "+",
          "slug": "il38"
        },
        {
          "symbol": "IL1RN",
          "ensemblId": "ENSG00000136689",
          "biotype": "protein_coding",
          "start": 113099315,
          "end": 113134016,
          "strand": "+",
          "slug": "il1rn"
        },
        {
          "symbol": "PSD4",
          "ensemblId": "ENSG00000125637",
          "biotype": "protein_coding",
          "start": 113157325,
          "end": 113209396,
          "strand": "+",
          "slug": "psd4"
        },
        {
          "symbol": "PAX8",
          "ensemblId": "ENSG00000125618",
          "biotype": "protein_coding",
          "start": 113215997,
          "end": 113279001,
          "strand": "-",
          "slug": "pax8"
        },
        {
          "symbol": "ZNG1B",
          "ensemblId": "ENSG00000136682",
          "biotype": "protein_coding",
          "start": 113437691,
          "end": 113496204,
          "strand": "+",
          "slug": "zng1b"
        },
        {
          "symbol": "FOXD4L1",
          "ensemblId": "ENSG00000184492",
          "biotype": "protein_coding",
          "start": 113498665,
          "end": 113501150,
          "strand": "+",
          "slug": "foxd4l1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "rare-monogenic-autoinflammatory-diseases",
        "name": "Zeldzame monogene auto-inflammatoire ziekten",
        "diseases": [
          {
            "mondoId": "MONDO:0013626",
            "name": "Gegeneraliseerde pustuleuze psoriasis (DITRA)",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Episodes van wijdverspreide steriele pustels met koorts, veroorzaakt door een tekort aan IL36RN.",
            "management": null,
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/rare-monogenic-autoinflammatory-diseases"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-nail-morphology",
        "name": "Abnormality of the nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-nail-morphology"
      },
      {
        "slug": "arthritis",
        "name": "Arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arthritis"
      },
      {
        "slug": "cholangitis",
        "name": "Bile duct inflammation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cholangitis"
      },
      {
        "slug": "congestive-heart-failure",
        "name": "Cardiac failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/congestive-heart-failure"
      },
      {
        "slug": "decreased-total-lymphocyte-count",
        "name": "Decreased blood lymphocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-total-lymphocyte-count"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "erythematous-plaque",
        "name": "Erythematous plaque",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/erythematous-plaque"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "pedal-edema",
        "name": "Fluid accumulation in lower limbs",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pedal-edema"
      },
      {
        "slug": "geographic-tongue",
        "name": "Geographic tongue",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/geographic-tongue"
      },
      {
        "slug": "furrowed-tongue",
        "name": "Grooved tongue",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/furrowed-tongue"
      },
      {
        "slug": "elevated-erythrocyte-sedimentation-rate",
        "name": "High ESR",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-erythrocyte-sedimentation-rate"
      },
      {
        "slug": "elevated-circulating-hepatic-transaminase-concentration",
        "name": "High liver enzymes",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/elevated-circulating-hepatic-transaminase-concentration"
      },
      {
        "slug": "increased-total-neutrophil-count",
        "name": "Increased blood neutrophil counts",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-total-neutrophil-count"
      },
      {
        "slug": "sepsis",
        "name": "Infection in blood stream",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/sepsis"
      },
      {
        "slug": "cheilitis",
        "name": "Inflammation of the lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cheilitis"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "hypoalbuminemia",
        "name": "Low albumin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoalbuminemia"
      },
      {
        "slug": "hypocalcemia",
        "name": "Low blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypocalcemia"
      },
      {
        "slug": "hyponatremia",
        "name": "Low blood sodium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyponatremia"
      },
      {
        "slug": "obesity",
        "name": "Obesity",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/obesity"
      },
      {
        "slug": "oligoarthritis",
        "name": "Oligoarthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligoarthritis"
      },
      {
        "slug": "overweight",
        "name": "Overweight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/overweight"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pain"
      },
      {
        "slug": "palmoplantar-pustulosis",
        "name": "Palmoplantar pustulosis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/palmoplantar-pustulosis"
      },
      {
        "slug": "parakeratosis",
        "name": "Parakeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/parakeratosis"
      },
      {
        "slug": "pustule",
        "name": "Pimple",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pustule"
      },
      {
        "slug": "polyarticular-arthritis",
        "name": "Polyarticular arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/polyarticular-arthritis"
      },
      {
        "slug": "nail-dystrophy",
        "name": "Poor nail formation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nail-dystrophy"
      },
      {
        "slug": "psoriasiform-dermatitis",
        "name": "Psoriasiform dermatitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/psoriasiform-dermatitis"
      },
      {
        "slug": "erythroderma",
        "name": "Red scaly skin caused by inflammatory skin disease",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/erythroderma"
      },
      {
        "slug": "erythema",
        "name": "Redness of skin or mucous membrane",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/erythema"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "epidermal-acanthosis",
        "name": "Thickening of upper layer of skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/epidermal-acanthosis"
      },
      {
        "slug": "uveitis",
        "name": "Uveitis",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/uveitis"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}