{
  "url": "https://dantelabs.com/nl/genes/arhgef11",
  "gene": {
    "slug": "arhgef11",
    "symbol": "ARHGEF11",
    "name": "Rho guanine nucleotide exchange factor 11",
    "hgnc": "HGNC:14580",
    "summary": null,
    "location": "1q23.1",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA0380",
      "GTRAP48",
      "PDZ-RHOGEF"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000132694",
    "entrezId": 9826,
    "omim": [
      "605708"
    ],
    "uniprot": [
      "O15085"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "1",
      "start": 156934840,
      "end": 157045742,
      "strand": "-",
      "ensemblTranscript": "ENST00000368194.8",
      "refseqTranscript": "NM_198236.3",
      "ensemblProtein": "ENSP00000357177.3",
      "refseqProtein": "NP_937879.1",
      "exons": [
        {
          "start": 156934840,
          "end": 156936058
        },
        {
          "start": 156936816,
          "end": 156937005
        },
        {
          "start": 156937249,
          "end": 156937496
        },
        {
          "start": 156938418,
          "end": 156938513
        },
        {
          "start": 156939548,
          "end": 156939910
        },
        {
          "start": 156940207,
          "end": 156940425
        },
        {
          "start": 156941372,
          "end": 156941433
        },
        {
          "start": 156941864,
          "end": 156941989
        },
        {
          "start": 156942690,
          "end": 156942780
        },
        {
          "start": 156943935,
          "end": 156944102
        },
        {
          "start": 156944358,
          "end": 156944433
        },
        {
          "start": 156945019,
          "end": 156945197
        },
        {
          "start": 156946045,
          "end": 156946162
        },
        {
          "start": 156946662,
          "end": 156946787
        },
        {
          "start": 156946936,
          "end": 156947015
        },
        {
          "start": 156947304,
          "end": 156947450
        },
        {
          "start": 156947769,
          "end": 156947956
        },
        {
          "start": 156948181,
          "end": 156948228
        },
        {
          "start": 156948319,
          "end": 156948498
        },
        {
          "start": 156951573,
          "end": 156951699
        },
        {
          "start": 156954892,
          "end": 156954921
        },
        {
          "start": 156955703,
          "end": 156955799
        },
        {
          "start": 156956420,
          "end": 156956564
        },
        {
          "start": 156957792,
          "end": 156957815
        },
        {
          "start": 156958742,
          "end": 156958864
        },
        {
          "start": 156959046,
          "end": 156959142
        },
        {
          "start": 156960418,
          "end": 156960460
        },
        {
          "start": 156961677,
          "end": 156961775
        },
        {
          "start": 156963203,
          "end": 156963304
        },
        {
          "start": 156963520,
          "end": 156963594
        },
        {
          "start": 156967987,
          "end": 156968124
        },
        {
          "start": 156969282,
          "end": 156969358
        },
        {
          "start": 156969998,
          "end": 156970043
        },
        {
          "start": 156971697,
          "end": 156971816
        },
        {
          "start": 156976983,
          "end": 156977054
        },
        {
          "start": 156978204,
          "end": 156978382
        },
        {
          "start": 156979229,
          "end": 156979286
        },
        {
          "start": 156980437,
          "end": 156980486
        },
        {
          "start": 156984339,
          "end": 156984437
        },
        {
          "start": 156986082,
          "end": 156986173
        },
        {
          "start": 157044299,
          "end": 157045742
        }
      ],
      "cds": {
        "start": 156936000,
        "end": 157044330
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
      "start": 156904632,
      "end": 157015162,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 156490291,
      "end": 157490290,
      "genes": [
        {
          "symbol": "MEF2D",
          "ensemblId": "ENSG00000116604",
          "biotype": "protein_coding",
          "start": 156463727,
          "end": 156501266,
          "strand": "-",
          "slug": "mef2d"
        },
        {
          "symbol": "IQGAP3",
          "ensemblId": "ENSG00000183856",
          "biotype": "protein_coding",
          "start": 156525405,
          "end": 156572604,
          "strand": "-",
          "slug": "iqgap3"
        },
        {
          "symbol": "TTC24",
          "ensemblId": "ENSG00000187862",
          "biotype": "protein_coding",
          "start": 156579723,
          "end": 156587719,
          "strand": "+",
          "slug": "ttc24"
        },
        {
          "symbol": "NAXE",
          "ensemblId": "ENSG00000163382",
          "biotype": "protein_coding",
          "start": 156591738,
          "end": 156609507,
          "strand": "+",
          "slug": "naxe"
        },
        {
          "symbol": "GPATCH4",
          "ensemblId": "ENSG00000160818",
          "biotype": "protein_coding",
          "start": 156594301,
          "end": 156601496,
          "strand": "-",
          "slug": "gpatch4"
        },
        {
          "symbol": "HAPLN2",
          "ensemblId": "ENSG00000132702",
          "biotype": "protein_coding",
          "start": 156619331,
          "end": 156626590,
          "strand": "+",
          "slug": "hapln2"
        },
        {
          "symbol": "BCAN",
          "ensemblId": "ENSG00000132692",
          "biotype": "protein_coding",
          "start": 156641390,
          "end": 156659532,
          "strand": "+",
          "slug": "bcan"
        },
        {
          "symbol": "NES",
          "ensemblId": "ENSG00000132688",
          "biotype": "protein_coding",
          "start": 156668763,
          "end": 156677415,
          "strand": "-",
          "slug": "nes"
        },
        {
          "symbol": "CRABP2",
          "ensemblId": "ENSG00000143320",
          "biotype": "protein_coding",
          "start": 156699592,
          "end": 156708094,
          "strand": "-",
          "slug": "crabp2"
        },
        {
          "symbol": "ISG20L2",
          "ensemblId": "ENSG00000143319",
          "biotype": "protein_coding",
          "start": 156720651,
          "end": 156728836,
          "strand": "-",
          "slug": "isg20l2"
        },
        {
          "symbol": "METTL25B",
          "ensemblId": "ENSG00000143303",
          "biotype": "protein_coding",
          "start": 156728442,
          "end": 156736960,
          "strand": "+",
          "slug": "mettl25b"
        },
        {
          "symbol": "MRPL24",
          "ensemblId": "ENSG00000143314",
          "biotype": "protein_coding",
          "start": 156737292,
          "end": 156741590,
          "strand": "-",
          "slug": "mrpl24"
        },
        {
          "symbol": "HDGF",
          "ensemblId": "ENSG00000143321",
          "biotype": "protein_coding",
          "start": 156742109,
          "end": 156766925,
          "strand": "-",
          "slug": "hdgf"
        },
        {
          "symbol": "PRCC",
          "ensemblId": "ENSG00000143294",
          "biotype": "protein_coding",
          "start": 156750610,
          "end": 156800818,
          "strand": "+",
          "slug": "prcc"
        },
        {
          "symbol": "SH2D2A",
          "ensemblId": "ENSG00000027869",
          "biotype": "protein_coding",
          "start": 156806235,
          "end": 156817014,
          "strand": "-",
          "slug": "sh2d2a"
        },
        {
          "symbol": "NTRK1",
          "ensemblId": "ENSG00000198400",
          "biotype": "protein_coding",
          "start": 156815636,
          "end": 156881850,
          "strand": "+",
          "slug": "ntrk1"
        },
        {
          "symbol": "INSRR",
          "ensemblId": "ENSG00000027644",
          "biotype": "protein_coding",
          "start": 156840063,
          "end": 156859122,
          "strand": "-",
          "slug": "insrr"
        },
        {
          "symbol": "PEAR1",
          "ensemblId": "ENSG00000187800",
          "biotype": "protein_coding",
          "start": 156893656,
          "end": 156916432,
          "strand": "+",
          "slug": "pear1"
        },
        {
          "symbol": "LRRC71",
          "ensemblId": "ENSG00000160838",
          "biotype": "protein_coding",
          "start": 156920631,
          "end": 156934915,
          "strand": "+",
          "slug": "lrrc71"
        },
        {
          "symbol": "ETV3L",
          "ensemblId": "ENSG00000253831",
          "biotype": "protein_coding",
          "start": 157092043,
          "end": 157117877,
          "strand": "-",
          "slug": "etv3l"
        },
        {
          "symbol": "ETV3",
          "ensemblId": "ENSG00000117036",
          "biotype": "protein_coding",
          "start": 157121191,
          "end": 157138952,
          "strand": "-",
          "slug": "etv3"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}