{
  "url": "https://dantelabs.com/nl/genes/agt",
  "gene": {
    "slug": "agt",
    "symbol": "AGT",
    "name": "angiotensinogen",
    "hgnc": "HGNC:333",
    "summary": null,
    "location": "1q42.2",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "SERPINA8"
    ],
    "ensemblId": "ENSG00000135744",
    "entrezId": 183,
    "omim": [
      "106150"
    ],
    "uniprot": [
      "P01019"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "1",
      "start": 230702523,
      "end": 230714122,
      "strand": "-",
      "ensemblTranscript": "ENST00000366667.6",
      "refseqTranscript": "NM_001384479.1",
      "ensemblProtein": "ENSP00000355627.5",
      "refseqProtein": "NP_001371408.1",
      "exons": [
        {
          "start": 230702523,
          "end": 230703329
        },
        {
          "start": 230704193,
          "end": 230704337
        },
        {
          "start": 230705933,
          "end": 230706200
        },
        {
          "start": 230709995,
          "end": 230710853
        },
        {
          "start": 230714086,
          "end": 230714122
        }
      ],
      "cds": {
        "start": 230703141,
        "end": 230710823
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
      "start": 230838269,
      "end": 230850043,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 230208323,
      "end": 231208322,
      "genes": [
        {
          "symbol": "GALNT2",
          "ensemblId": "ENSG00000143641",
          "biotype": "protein_coding",
          "start": 230057990,
          "end": 230282128,
          "strand": "+",
          "slug": "galnt2"
        },
        {
          "symbol": "PGBD5",
          "ensemblId": "ENSG00000177614",
          "biotype": "protein_coding",
          "start": 230314490,
          "end": 230426370,
          "strand": "-",
          "slug": "pgbd5"
        },
        {
          "symbol": "COG2",
          "ensemblId": "ENSG00000135775",
          "biotype": "protein_coding",
          "start": 230642440,
          "end": 230693985,
          "strand": "+",
          "slug": "cog2"
        },
        {
          "symbol": "CAPN9",
          "ensemblId": "ENSG00000135773",
          "biotype": "protein_coding",
          "start": 230747266,
          "end": 230804397,
          "strand": "+",
          "slug": "capn9"
        },
        {
          "symbol": "C1orf198",
          "ensemblId": "ENSG00000119280",
          "biotype": "protein_coding",
          "start": 230837119,
          "end": 230869589,
          "strand": "-",
          "slug": "c1orf198"
        },
        {
          "symbol": "TTC13",
          "ensemblId": "ENSG00000143643",
          "biotype": "protein_coding",
          "start": 230902936,
          "end": 230978893,
          "strand": "-",
          "slug": "ttc13"
        },
        {
          "symbol": "ARV1",
          "ensemblId": "ENSG00000173409",
          "biotype": "protein_coding",
          "start": 230978981,
          "end": 231000735,
          "strand": "+",
          "slug": "arv1"
        },
        {
          "symbol": "FAM89A",
          "ensemblId": "ENSG00000182118",
          "biotype": "protein_coding",
          "start": 230999826,
          "end": 231040270,
          "strand": "-",
          "slug": "fam89a"
        },
        {
          "symbol": "TRIM67",
          "ensemblId": "ENSG00000119283",
          "biotype": "protein_coding",
          "start": 231162058,
          "end": 231221565,
          "strand": "+",
          "slug": "trim67"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "renal-tubular-dysgenesis",
        "name": "Renale tubulaire dysgenesie",
        "diseases": [
          {
            "mondoId": "MONDO:0017609",
            "name": "Renale tubulaire dysgenesie",
            "genes": 4,
            "inheritance": "autosomal-recessive",
            "description": "Een recessieve aandoening van het renine-angiotensinesysteem, veroorzaakt door varianten in REN, AGT, ACE of AGTR1. Hierdoor wordt er al vóór de geboorte geen urine aangemaakt, en bij pasgeborenen is de aandoening meestal fataal.",
            "management": "Dragerschap kan voor stellen relevant zijn bij het plannen van een gezin.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/nl/conditions/renal-tubular-dysgenesis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "microcephaly",
        "name": "Abnormally small head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/microcephaly"
      },
      {
        "slug": "anuria",
        "name": "Absent urine output",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/anuria"
      },
      {
        "slug": "hypotension",
        "name": "Low blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/hypotension"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "pulmonary-hypoplasia",
        "name": "Poorly developed lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/pulmonary-hypoplasia"
      },
      {
        "slug": "potter-facies",
        "name": "Potter facies",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/potter-facies"
      },
      {
        "slug": "renotubular-dysgenesis",
        "name": "Renotubular dysgenesis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renotubular-dysgenesis"
      },
      {
        "slug": "respiratory-insufficiency",
        "name": "Respiratory function loss",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/respiratory-insufficiency"
      },
      {
        "slug": "abnormality-of-the-urinary-system",
        "name": "Urinary tract abnormalities",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-urinary-system"
      },
      {
        "slug": "widely-patent-fontanelles-and-sutures",
        "name": "Widely patent fontanelles and sutures",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/widely-patent-fontanelles-and-sutures"
      }
    ],
    "related": [
      {
        "slug": "ace",
        "symbol": "ACE",
        "name": "angiotensin I converting enzyme",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/ace"
      },
      {
        "slug": "agtr1",
        "symbol": "AGTR1",
        "name": "angiotensin II receptor type 1",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/agtr1"
      },
      {
        "slug": "ren",
        "symbol": "REN",
        "name": "renin",
        "shared": 1,
        "url": "https://dantelabs.com/nl/genes/ren"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}