{
  "url": "https://dantelabs.com/traits/type-e-brachydactyly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "type-e-brachydactyly",
    "id": "HP:0005863",
    "name": "Type E brachydactyly",
    "definition": "In type E brachydactyly, shortening of the fingers is mainly in the metacarpals and metatarsals.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "url": "https://dantelabs.com/traits/brachydactyly"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "pde3a",
        "symbol": "PDE3A",
        "hgnc": "HGNC:8778",
        "name": "phosphodiesterase 3A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde3a"
      },
      {
        "slug": "pthlh",
        "symbol": "PTHLH",
        "hgnc": "HGNC:9607",
        "name": "parathyroid hormone like hormone",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pthlh"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      }
    ]
  }
}