{
  "url": "https://dantelabs.com/traits/spastic-hyperactive-bladder",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "spastic-hyperactive-bladder",
    "id": "HP:0005340",
    "name": "Spastic/hyperactive bladder",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "functional-abnormality-of-the-bladder",
        "name": "Functional abnormality of the bladder",
        "url": "https://dantelabs.com/traits/functional-abnormality-of-the-bladder"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dnajc13",
        "symbol": "DNAJC13",
        "hgnc": "HGNC:30343",
        "name": "DnaJ heat shock protein family (Hsp40) member C13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc13"
      },
      {
        "slug": "eif4g1",
        "symbol": "EIF4G1",
        "hgnc": "HGNC:3296",
        "name": "eukaryotic translation initiation factor 4 gamma 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4g1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gigyf2",
        "symbol": "GIGYF2",
        "hgnc": "HGNC:11960",
        "name": "GRB10 interacting GYF protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gigyf2"
      },
      {
        "slug": "kif5a",
        "symbol": "KIF5A",
        "hgnc": "HGNC:6323",
        "name": "kinesin family member 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif5a"
      },
      {
        "slug": "lrrk2",
        "symbol": "LRRK2",
        "hgnc": "HGNC:18618",
        "name": "leucine rich repeat kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrk2"
      },
      {
        "slug": "plp1",
        "symbol": "PLP1",
        "hgnc": "HGNC:9086",
        "name": "proteolipid protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plp1"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "vps35",
        "symbol": "VPS35",
        "hgnc": "HGNC:13487",
        "name": "VPS35 retromer complex component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps35"
      },
      {
        "slug": "lrig2",
        "symbol": "LRIG2",
        "hgnc": "HGNC:20889",
        "name": "leucine rich repeats and immunoglobulin like domains 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrig2"
      },
      {
        "slug": "dars2",
        "symbol": "DARS2",
        "hgnc": "HGNC:25538",
        "name": "aspartyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dars2"
      }
    ]
  }
}