{
  "url": "https://dantelabs.com/traits/progressive-intervertebral-space-narrowing",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "progressive-intervertebral-space-narrowing",
    "id": "HP:0004622",
    "name": "Progressive intervertebral space narrowing",
    "definition": "A progressive form of decreased height of the intervertebral disk.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "intervertebral-space-narrowing",
        "name": "Intervertebral space narrowing",
        "url": "https://dantelabs.com/traits/intervertebral-space-narrowing"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mt-atp8",
        "symbol": "MT-ATP8",
        "hgnc": "HGNC:7415",
        "name": "mitochondrially encoded ATP synthase membrane subunit 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp8"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      }
    ]
  }
}