{
  "url": "https://dantelabs.com/traits/primary-amenorrhea",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "primary-amenorrhea",
    "id": "HP:0000786",
    "name": "Primary amenorrhea",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "amenorrhea",
        "name": "Abnormal absence of menstruation",
        "url": "https://dantelabs.com/traits/amenorrhea"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "anos1",
        "symbol": "ANOS1",
        "hgnc": "HGNC:6211",
        "name": "anosmin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/anos1"
      },
      {
        "slug": "arl6",
        "symbol": "ARL6",
        "hgnc": "HGNC:13210",
        "name": "ARF like GTPase 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arl6"
      },
      {
        "slug": "axl",
        "symbol": "AXL",
        "hgnc": "HGNC:905",
        "name": "AXL receptor tyrosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/axl"
      },
      {
        "slug": "bbs1",
        "symbol": "BBS1",
        "hgnc": "HGNC:966",
        "name": "Bardet-Biedl syndrome 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs1"
      },
      {
        "slug": "bmp15",
        "symbol": "BMP15",
        "hgnc": "HGNC:1068",
        "name": "bone morphogenetic protein 15",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bmp15"
      },
      {
        "slug": "bmpr1b",
        "symbol": "BMPR1B",
        "hgnc": "HGNC:1077",
        "name": "bone morphogenetic protein receptor type 1B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1b"
      },
      {
        "slug": "ccdc141",
        "symbol": "CCDC141",
        "hgnc": "HGNC:26821",
        "name": "coiled-coil domain containing 141",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ccdc141"
      },
      {
        "slug": "ccdc28b",
        "symbol": "CCDC28B",
        "hgnc": "HGNC:28163",
        "name": "coiled-coil domain containing 28B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc28b"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "cpe",
        "symbol": "CPE",
        "hgnc": "HGNC:2303",
        "name": "carboxypeptidase E",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpe"
      },
      {
        "slug": "dcaf17",
        "symbol": "DCAF17",
        "hgnc": "HGNC:25784",
        "name": "DDB1 and CUL4 associated factor 17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcaf17"
      },
      {
        "slug": "dhh",
        "symbol": "DHH",
        "hgnc": "HGNC:2865",
        "name": "desert hedgehog signaling molecule",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dhh"
      },
      {
        "slug": "dusp6",
        "symbol": "DUSP6",
        "hgnc": "HGNC:3072",
        "name": "dual specificity phosphatase 6",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dusp6"
      },
      {
        "slug": "esr1",
        "symbol": "ESR1",
        "hgnc": "HGNC:3467",
        "name": "estrogen receptor 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/esr1"
      },
      {
        "slug": "esr2",
        "symbol": "ESR2",
        "hgnc": "HGNC:3468",
        "name": "estrogen receptor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esr2"
      },
      {
        "slug": "fezf1",
        "symbol": "FEZF1",
        "hgnc": "HGNC:22788",
        "name": "FEZ family zinc finger 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/fezf1"
      },
      {
        "slug": "fgf17",
        "symbol": "FGF17",
        "hgnc": "HGNC:3673",
        "name": "fibroblast growth factor 17",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/fgf17"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "hgnc": "HGNC:3686",
        "name": "fibroblast growth factor 8",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgf8"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "flrt3",
        "symbol": "FLRT3",
        "hgnc": "HGNC:3762",
        "name": "fibronectin leucine rich transmembrane protein 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flrt3"
      },
      {
        "slug": "fshb",
        "symbol": "FSHB",
        "hgnc": "HGNC:3964",
        "name": "follicle stimulating hormone subunit beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fshb"
      },
      {
        "slug": "gata3",
        "symbol": "GATA3",
        "hgnc": "HGNC:4172",
        "name": "GATA binding protein 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata3"
      },
      {
        "slug": "gdf9",
        "symbol": "GDF9",
        "hgnc": "HGNC:4224",
        "name": "growth differentiation factor 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf9"
      },
      {
        "slug": "gnrh1",
        "symbol": "GNRH1",
        "hgnc": "HGNC:4419",
        "name": "gonadotropin releasing hormone 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gnrh1"
      },
      {
        "slug": "gnrhr",
        "symbol": "GNRHR",
        "hgnc": "HGNC:4421",
        "name": "gonadotropin releasing hormone receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gnrhr"
      },
      {
        "slug": "hs6st1",
        "symbol": "HS6ST1",
        "hgnc": "HGNC:5201",
        "name": "heparan sulfate 6-O-sulfotransferase 1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/hs6st1"
      },
      {
        "slug": "kiss1",
        "symbol": "KISS1",
        "hgnc": "HGNC:6341",
        "name": "KiSS-1 metastasis suppressor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kiss1"
      },
      {
        "slug": "kiss1r",
        "symbol": "KISS1R",
        "hgnc": "HGNC:4510",
        "name": "KISS1 receptor",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/kiss1r"
      },
      {
        "slug": "mau2",
        "symbol": "MAU2",
        "hgnc": "HGNC:29140",
        "name": "MAU2 sister chromatid cohesion factor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mau2"
      },
      {
        "slug": "mcm9",
        "symbol": "MCM9",
        "hgnc": "HGNC:21484",
        "name": "minichromosome maintenance 9 homologous recombination repair factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcm9"
      },
      {
        "slug": "ndnf",
        "symbol": "NDNF",
        "hgnc": "HGNC:26256",
        "name": "neuron derived neurotrophic factor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndnf"
      },
      {
        "slug": "nin",
        "symbol": "NIN",
        "hgnc": "HGNC:14906",
        "name": "ninein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nin"
      },
      {
        "slug": "nsmf",
        "symbol": "NSMF",
        "hgnc": "HGNC:29843",
        "name": "NMDA receptor synaptonuclear signaling and neuronal migration factor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nsmf"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "pnpla6",
        "symbol": "PNPLA6",
        "hgnc": "HGNC:16268",
        "name": "patatin like domain 6, lysophospholipase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpla6"
      },
      {
        "slug": "pof1b",
        "symbol": "POF1B",
        "hgnc": "HGNC:13711",
        "name": "POF1B actin binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pof1b"
      },
      {
        "slug": "prok2",
        "symbol": "PROK2",
        "hgnc": "HGNC:18455",
        "name": "prokineticin 2",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/prok2"
      },
      {
        "slug": "prokr2",
        "symbol": "PROKR2",
        "hgnc": "HGNC:15836",
        "name": "prokineticin receptor 2",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/prokr2"
      },
      {
        "slug": "psmc3ip",
        "symbol": "PSMC3IP",
        "hgnc": "HGNC:17928",
        "name": "PSMC3 interacting protein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/psmc3ip"
      },
      {
        "slug": "sema3a",
        "symbol": "SEMA3A",
        "hgnc": "HGNC:10723",
        "name": "semaphorin 3A",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sema3a"
      },
      {
        "slug": "sema3e",
        "symbol": "SEMA3E",
        "hgnc": "HGNC:10727",
        "name": "semaphorin 3E",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3e"
      },
      {
        "slug": "sohlh1",
        "symbol": "SOHLH1",
        "hgnc": "HGNC:27845",
        "name": "spermatogenesis and oogenesis specific basic helix-loop-helix 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sohlh1"
      },
      {
        "slug": "sox10",
        "symbol": "SOX10",
        "hgnc": "HGNC:11190",
        "name": "SRY-box transcription factor 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sox10"
      },
      {
        "slug": "spidr",
        "symbol": "SPIDR",
        "hgnc": "HGNC:28971",
        "name": "scaffold protein involved in DNA repair",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spidr"
      },
      {
        "slug": "spry4",
        "symbol": "SPRY4",
        "hgnc": "HGNC:15533",
        "name": "sprouty RTK signaling antagonist 4",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/spry4"
      },
      {
        "slug": "sra1",
        "symbol": "SRA1",
        "hgnc": "HGNC:11281",
        "name": "steroid receptor RNA activator 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sra1"
      },
      {
        "slug": "sry",
        "symbol": "SRY",
        "hgnc": "HGNC:11311",
        "name": "sex determining region Y",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sry"
      },
      {
        "slug": "tac3",
        "symbol": "TAC3",
        "hgnc": "HGNC:11521",
        "name": "tachykinin precursor 3",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tac3"
      },
      {
        "slug": "tacr3",
        "symbol": "TACR3",
        "hgnc": "HGNC:11528",
        "name": "tachykinin receptor 3",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tacr3"
      },
      {
        "slug": "wdr11",
        "symbol": "WDR11",
        "hgnc": "HGNC:13831",
        "name": "WD repeat domain 11",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/wdr11"
      },
      {
        "slug": "wnt4",
        "symbol": "WNT4",
        "hgnc": "HGNC:12783",
        "name": "Wnt family member 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wnt4"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "yars1",
        "symbol": "YARS1",
        "hgnc": "HGNC:12840",
        "name": "tyrosyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars1"
      },
      {
        "slug": "zswim7",
        "symbol": "ZSWIM7",
        "hgnc": "HGNC:26993",
        "name": "zinc finger SWIM-type containing 7",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zswim7"
      },
      {
        "slug": "ar",
        "symbol": "AR",
        "hgnc": "HGNC:644",
        "name": "androgen receptor",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ar"
      },
      {
        "slug": "bnc1",
        "symbol": "BNC1",
        "hgnc": "HGNC:1081",
        "name": "basonuclin zinc finger protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bnc1"
      },
      {
        "slug": "cyb5a",
        "symbol": "CYB5A",
        "hgnc": "HGNC:2570",
        "name": "cytochrome b5 type A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyb5a"
      },
      {
        "slug": "cyp17a1",
        "symbol": "CYP17A1",
        "hgnc": "HGNC:2593",
        "name": "cytochrome P450 family 17 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/cyp17a1"
      },
      {
        "slug": "cyp19a1",
        "symbol": "CYP19A1",
        "hgnc": "HGNC:2594",
        "name": "cytochrome P450 family 19 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp19a1"
      },
      {
        "slug": "dhx37",
        "symbol": "DHX37",
        "hgnc": "HGNC:17210",
        "name": "DEAH-box helicase 37",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dhx37"
      },
      {
        "slug": "emx2",
        "symbol": "EMX2",
        "hgnc": "HGNC:3341",
        "name": "empty spiracles homeobox 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/emx2"
      },
      {
        "slug": "figla",
        "symbol": "FIGLA",
        "hgnc": "HGNC:24669",
        "name": "folliculogenesis specific bHLH transcription factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/figla"
      },
      {
        "slug": "fshr",
        "symbol": "FSHR",
        "hgnc": "HGNC:3969",
        "name": "follicle stimulating hormone receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fshr"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "lep",
        "symbol": "LEP",
        "hgnc": "HGNC:6553",
        "name": "leptin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lep"
      },
      {
        "slug": "lepr",
        "symbol": "LEPR",
        "hgnc": "HGNC:6554",
        "name": "leptin receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lepr"
      },
      {
        "slug": "map3k1",
        "symbol": "MAP3K1",
        "hgnc": "HGNC:6848",
        "name": "mitogen-activated protein kinase kinase kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k1"
      },
      {
        "slug": "mrps22",
        "symbol": "MRPS22",
        "hgnc": "HGNC:14508",
        "name": "mitochondrial ribosomal protein S22",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mrps22"
      },
      {
        "slug": "msh4",
        "symbol": "MSH4",
        "hgnc": "HGNC:7327",
        "name": "mutS homolog 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh4"
      },
      {
        "slug": "nhlh2",
        "symbol": "NHLH2",
        "hgnc": "HGNC:7818",
        "name": "nescient helix-loop-helix 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhlh2"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "nr5a1",
        "symbol": "NR5A1",
        "hgnc": "HGNC:7983",
        "name": "nuclear receptor subfamily 5 group A member 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nr5a1"
      },
      {
        "slug": "polr3h",
        "symbol": "POLR3H",
        "hgnc": "HGNC:30349",
        "name": "RNA polymerase III subunit H",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3h"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "stag3",
        "symbol": "STAG3",
        "hgnc": "HGNC:11356",
        "name": "STAG3 cohesin complex component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stag3"
      },
      {
        "slug": "vamp7",
        "symbol": "VAMP7",
        "hgnc": "HGNC:11486",
        "name": "vesicle associated membrane protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp7"
      },
      {
        "slug": "wwox",
        "symbol": "WWOX",
        "hgnc": "HGNC:12799",
        "name": "WW domain containing oxidoreductase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wwox"
      },
      {
        "slug": "zfpm2",
        "symbol": "ZFPM2",
        "hgnc": "HGNC:16700",
        "name": "zinc finger protein, FOG family member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfpm2"
      },
      {
        "slug": "clpp",
        "symbol": "CLPP",
        "hgnc": "HGNC:2084",
        "name": "caseinolytic mitochondrial matrix peptidase proteolytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpp"
      },
      {
        "slug": "dap3",
        "symbol": "DAP3",
        "hgnc": "HGNC:2673",
        "name": "death associated protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dap3"
      },
      {
        "slug": "eif2b4",
        "symbol": "EIF2B4",
        "hgnc": "HGNC:3260",
        "name": "eukaryotic translation initiation factor 2B subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2b4"
      },
      {
        "slug": "eral1",
        "symbol": "ERAL1",
        "hgnc": "HGNC:3424",
        "name": "Era like 12S mitochondrial rRNA chaperone 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eral1"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "hrob",
        "symbol": "HROB",
        "hgnc": "HGNC:28460",
        "name": "homologous recombination factor with OB-fold",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hrob"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "magel2",
        "symbol": "MAGEL2",
        "hgnc": "HGNC:6814",
        "name": "MAGE family member L2",
        "frequency": "frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/magel2"
      },
      {
        "slug": "msto1",
        "symbol": "MSTO1",
        "hgnc": "HGNC:29678",
        "name": "misato mitochondrial distribution and morphology regulator 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/msto1"
      },
      {
        "slug": "ndn",
        "symbol": "NDN",
        "hgnc": "HGNC:7675",
        "name": "necdin, MAGE family member",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ndn"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "pex1",
        "symbol": "PEX1",
        "hgnc": "HGNC:8850",
        "name": "peroxisomal biogenesis factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex1"
      },
      {
        "slug": "pex6",
        "symbol": "PEX6",
        "hgnc": "HGNC:8859",
        "name": "peroxisomal biogenesis factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex6"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "pparg",
        "symbol": "PPARG",
        "hgnc": "HGNC:9236",
        "name": "peroxisome proliferator activated receptor gamma",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pparg"
      },
      {
        "slug": "prorp",
        "symbol": "PRORP",
        "hgnc": "HGNC:19958",
        "name": "protein only RNase P catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prorp"
      },
      {
        "slug": "sim1",
        "symbol": "SIM1",
        "hgnc": "HGNC:10882",
        "name": "SIM bHLH transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sim1"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "trmt10a",
        "symbol": "TRMT10A",
        "hgnc": "HGNC:28403",
        "name": "tRNA methyltransferase 10A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10a"
      },
      {
        "slug": "brd4",
        "symbol": "BRD4",
        "hgnc": "HGNC:13575",
        "name": "bromodomain containing 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brd4"
      },
      {
        "slug": "cdon",
        "symbol": "CDON",
        "hgnc": "HGNC:17104",
        "name": "cell adhesion associated, oncogene regulated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdon"
      },
      {
        "slug": "ctdp1",
        "symbol": "CTDP1",
        "hgnc": "HGNC:2498",
        "name": "CTD phosphatase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctdp1"
      },
      {
        "slug": "dcc",
        "symbol": "DCC",
        "hgnc": "HGNC:2701",
        "name": "DCC netrin 1 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcc"
      },
      {
        "slug": "fbxo11",
        "symbol": "FBXO11",
        "hgnc": "HGNC:13590",
        "name": "F-box protein 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo11"
      },
      {
        "slug": "gpr161",
        "symbol": "GPR161",
        "hgnc": "HGNC:23694",
        "name": "G protein-coupled receptor 161",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr161"
      },
      {
        "slug": "hdac8",
        "symbol": "HDAC8",
        "hgnc": "HGNC:13315",
        "name": "histone deacetylase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac8"
      },
      {
        "slug": "herc2",
        "symbol": "HERC2",
        "hgnc": "HGNC:4868",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/herc2"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "il17rd",
        "symbol": "IL17RD",
        "hgnc": "HGNC:17616",
        "name": "interleukin 17 receptor D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17rd"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "mga",
        "symbol": "MGA",
        "hgnc": "HGNC:14010",
        "name": "MAX dimerization protein MGA",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mga"
      },
      {
        "slug": "mkrn3",
        "symbol": "MKRN3",
        "hgnc": "HGNC:7114",
        "name": "makorin ring finger protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mkrn3"
      },
      {
        "slug": "nipbl",
        "symbol": "NIPBL",
        "hgnc": "HGNC:28862",
        "name": "NIPBL cohesin loading factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nipbl"
      },
      {
        "slug": "nobox",
        "symbol": "NOBOX",
        "hgnc": "HGNC:22448",
        "name": "NOBOX oogenesis homeobox",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nobox"
      },
      {
        "slug": "npap1",
        "symbol": "NPAP1",
        "hgnc": "HGNC:1190",
        "name": "nuclear pore associated protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npap1"
      },
      {
        "slug": "pwar1",
        "symbol": "PWAR1",
        "hgnc": "HGNC:30089",
        "name": "Prader Willi/Angelman region RNA 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pwar1"
      },
      {
        "slug": "pwrn1",
        "symbol": "PWRN1",
        "hgnc": "HGNC:33235",
        "name": "Prader-Willi region non-protein coding RNA 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pwrn1"
      },
      {
        "slug": "rad21",
        "symbol": "RAD21",
        "hgnc": "HGNC:9811",
        "name": "RAD21 cohesin complex component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad21"
      },
      {
        "slug": "rnf216",
        "symbol": "RNF216",
        "hgnc": "HGNC:21698",
        "name": "ring finger protein 216",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf216"
      },
      {
        "slug": "robo1",
        "symbol": "ROBO1",
        "hgnc": "HGNC:10249",
        "name": "roundabout guidance receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/robo1"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "smc3",
        "symbol": "SMC3",
        "hgnc": "HGNC:2468",
        "name": "structural maintenance of chromosomes 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc3"
      },
      {
        "slug": "snord115-1",
        "symbol": "SNORD115-1",
        "hgnc": "HGNC:33020",
        "name": "small nucleolar RNA, C/D box 115-1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snord115-1"
      },
      {
        "slug": "snord116-1",
        "symbol": "SNORD116-1",
        "hgnc": "HGNC:33067",
        "name": "small nucleolar RNA, C/D box 116-1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snord116-1"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      },
      {
        "slug": "cisd2",
        "symbol": "CISD2",
        "hgnc": "HGNC:24212",
        "name": "CDGSH iron sulfur domain 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cisd2"
      },
      {
        "slug": "eif2b1",
        "symbol": "EIF2B1",
        "hgnc": "HGNC:3257",
        "name": "eukaryotic translation initiation factor 2B subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2b1"
      },
      {
        "slug": "hsd17b4",
        "symbol": "HSD17B4",
        "hgnc": "HGNC:5213",
        "name": "hydroxysteroid 17-beta dehydrogenase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b4"
      },
      {
        "slug": "itga8",
        "symbol": "ITGA8",
        "hgnc": "HGNC:6144",
        "name": "integrin subunit alpha 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga8"
      },
      {
        "slug": "mcm8",
        "symbol": "MCM8",
        "hgnc": "HGNC:16147",
        "name": "minichromosome maintenance 8 homologous recombination repair factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcm8"
      },
      {
        "slug": "pcsk1",
        "symbol": "PCSK1",
        "hgnc": "HGNC:8743",
        "name": "proprotein convertase subtilisin/kexin type 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk1"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "smchd1",
        "symbol": "SMCHD1",
        "hgnc": "HGNC:29090",
        "name": "structural maintenance of chromosomes flexible hinge domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smchd1"
      },
      {
        "slug": "syce1",
        "symbol": "SYCE1",
        "hgnc": "HGNC:28852",
        "name": "synaptonemal complex central element protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syce1"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      }
    ]
  }
}