{
  "url": "https://dantelabs.com/traits/patchy-hypo-and-hyperpigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "patchy-hypo-and-hyperpigmentation",
    "id": "HP:0007509",
    "name": "Patchy hypo- and hyperpigmentation",
    "synonyms": [
      "Patchy hypo- and hyper-pigmentation"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "mixed-hypo-and-hyperpigmentation-of-the-skin",
        "name": "Mixed hypo- and hyperpigmentation of the skin",
        "url": "https://dantelabs.com/traits/mixed-hypo-and-hyperpigmentation-of-the-skin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "sms",
        "symbol": "SMS",
        "hgnc": "HGNC:11123",
        "name": "spermine synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sms"
      },
      {
        "slug": "ube2a",
        "symbol": "UBE2A",
        "hgnc": "HGNC:12472",
        "name": "ubiquitin conjugating enzyme E2 A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2a"
      }
    ]
  }
}