{
  "url": "https://dantelabs.com/traits/pancytopenia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "pancytopenia",
    "id": "HP:0001876",
    "name": "Low blood cell count",
    "label": "Pancytopenia",
    "definition": "An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).",
    "synonyms": [
      "Pancytopaenia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-multiple-cell-lineages-in-the-bone-marrow",
        "name": "Abnormality of multiple cell lineages in the bone marrow",
        "url": "https://dantelabs.com/traits/abnormality-of-multiple-cell-lineages-in-the-bone-marrow"
      }
    ],
    "narrower": [
      {
        "slug": "aplastic-anemia",
        "name": "Aplastic anemia",
        "genes": 29,
        "url": "https://dantelabs.com/traits/aplastic-anemia"
      }
    ],
    "genes": [
      {
        "slug": "ak2",
        "symbol": "AK2",
        "hgnc": "HGNC:362",
        "name": "adenylate kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak2"
      },
      {
        "slug": "dnase2",
        "symbol": "DNASE2",
        "hgnc": "HGNC:2960",
        "name": "deoxyribonuclease 2, lysosomal",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase2"
      },
      {
        "slug": "dpp9",
        "symbol": "DPP9",
        "hgnc": "HGNC:18648",
        "name": "dipeptidyl peptidase 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpp9"
      },
      {
        "slug": "exoc3l2",
        "symbol": "EXOC3L2",
        "hgnc": "HGNC:30162",
        "name": "exocyst complex component 3 like 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exoc3l2"
      },
      {
        "slug": "faap100",
        "symbol": "FAAP100",
        "hgnc": "HGNC:26171",
        "name": "FA core complex associated protein 100",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faap100"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "hgnc": "HGNC:3584",
        "name": "FA complementation group C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancc"
      },
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "ikzf1",
        "symbol": "IKZF1",
        "hgnc": "HGNC:13176",
        "name": "IKAROS family zinc finger 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf1"
      },
      {
        "slug": "itch",
        "symbol": "ITCH",
        "hgnc": "HGNC:13890",
        "name": "itchy E3 ubiquitin protein ligase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itch"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "mthfd1",
        "symbol": "MTHFD1",
        "hgnc": "HGNC:7432",
        "name": "methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfd1"
      },
      {
        "slug": "pld4",
        "symbol": "PLD4",
        "hgnc": "HGNC:23792",
        "name": "phospholipase D family member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pld4"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "ptprc",
        "symbol": "PTPRC",
        "hgnc": "HGNC:9666",
        "name": "protein tyrosine phosphatase receptor type C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprc"
      },
      {
        "slug": "rpl17",
        "symbol": "RPL17",
        "hgnc": "HGNC:10307",
        "name": "ribosomal protein L17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl17"
      },
      {
        "slug": "sh2d1a",
        "symbol": "SH2D1A",
        "hgnc": "HGNC:10820",
        "name": "SH2 domain containing 1A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2d1a"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "spout1",
        "symbol": "SPOUT1",
        "hgnc": "HGNC:26933",
        "name": "SPOUT domain containing methyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spout1"
      },
      {
        "slug": "stn1",
        "symbol": "STN1",
        "hgnc": "HGNC:26200",
        "name": "STN1 subunit of CST complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stn1"
      },
      {
        "slug": "thpo",
        "symbol": "THPO",
        "hgnc": "HGNC:11795",
        "name": "thrombopoietin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thpo"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "xiap",
        "symbol": "XIAP",
        "hgnc": "HGNC:592",
        "name": "X-linked inhibitor of apoptosis",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/xiap"
      },
      {
        "slug": "alpk1",
        "symbol": "ALPK1",
        "hgnc": "HGNC:20917",
        "name": "alpha kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "very-frequent",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "rab27a",
        "symbol": "RAB27A",
        "hgnc": "HGNC:9766",
        "name": "RAB27A, member RAS oncogene family",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab27a"
      },
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada2"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "dclre1b",
        "symbol": "DCLRE1B",
        "hgnc": "HGNC:17641",
        "name": "DNA cross-link repair 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1b"
      },
      {
        "slug": "dnajc21",
        "symbol": "DNAJC21",
        "hgnc": "HGNC:27030",
        "name": "DnaJ heat shock protein family (Hsp40) member C21",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dnajc21"
      },
      {
        "slug": "dut",
        "symbol": "DUT",
        "hgnc": "HGNC:3078",
        "name": "deoxyuridine triphosphatase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dut"
      },
      {
        "slug": "fip1l1",
        "symbol": "FIP1L1",
        "hgnc": "HGNC:19124",
        "name": "factor interacting with PAPOLA and CPSF1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fip1l1"
      },
      {
        "slug": "gale",
        "symbol": "GALE",
        "hgnc": "HGNC:4116",
        "name": "UDP-galactose-4-epimerase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gale"
      },
      {
        "slug": "ifng",
        "symbol": "IFNG",
        "hgnc": "HGNC:5438",
        "name": "interferon gamma",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ifng"
      },
      {
        "slug": "irf2bp2",
        "symbol": "IRF2BP2",
        "hgnc": "HGNC:21729",
        "name": "interferon regulatory factor 2 binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf2bp2"
      },
      {
        "slug": "itk",
        "symbol": "ITK",
        "hgnc": "HGNC:6171",
        "name": "IL2 inducible T cell kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itk"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lig4"
      },
      {
        "slug": "mrps7",
        "symbol": "MRPS7",
        "hgnc": "HGNC:14499",
        "name": "mitochondrial ribosomal protein S7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps7"
      },
      {
        "slug": "nabp1",
        "symbol": "NABP1",
        "hgnc": "HGNC:26232",
        "name": "nucleic acid binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nabp1"
      },
      {
        "slug": "naxd",
        "symbol": "NAXD",
        "hgnc": "HGNC:25576",
        "name": "NAD(P)HX dehydratase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/naxd"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "nhp2",
        "symbol": "NHP2",
        "hgnc": "HGNC:14377",
        "name": "NHP2 ribonucleoprotein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nhp2"
      },
      {
        "slug": "nlrc4",
        "symbol": "NLRC4",
        "hgnc": "HGNC:16412",
        "name": "NLR family CARD domain containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nlrc4"
      },
      {
        "slug": "nop10",
        "symbol": "NOP10",
        "hgnc": "HGNC:14378",
        "name": "NOP10 ribonucleoprotein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nop10"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "numa1",
        "symbol": "NUMA1",
        "hgnc": "HGNC:8059",
        "name": "nuclear mitotic apparatus protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/numa1"
      },
      {
        "slug": "ostm1",
        "symbol": "OSTM1",
        "hgnc": "HGNC:21652",
        "name": "osteoclastogenesis associated transmembrane protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ostm1"
      },
      {
        "slug": "pml",
        "symbol": "PML",
        "hgnc": "HGNC:9113",
        "name": "PML nuclear body scaffold",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pml"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "psmb9",
        "symbol": "PSMB9",
        "hgnc": "HGNC:9546",
        "name": "proteasome 20S subunit beta 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb9"
      },
      {
        "slug": "rac2",
        "symbol": "RAC2",
        "hgnc": "HGNC:9802",
        "name": "Rac family small GTPase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rac2"
      },
      {
        "slug": "rap1b",
        "symbol": "RAP1B",
        "hgnc": "HGNC:9857",
        "name": "RAP1B, member of RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rap1b"
      },
      {
        "slug": "rara",
        "symbol": "RARA",
        "hgnc": "HGNC:9864",
        "name": "retinoic acid receptor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rara"
      },
      {
        "slug": "sars2",
        "symbol": "SARS2",
        "hgnc": "HGNC:17697",
        "name": "seryl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sars2"
      },
      {
        "slug": "sbds",
        "symbol": "SBDS",
        "hgnc": "HGNC:19440",
        "name": "SBDS ribosome maturation factor",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sbds"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "slx4",
        "symbol": "SLX4",
        "hgnc": "HGNC:23845",
        "name": "SLX4 structure-specific endonuclease subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slx4"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcal1"
      },
      {
        "slug": "srp72",
        "symbol": "SRP72",
        "hgnc": "HGNC:11303",
        "name": "signal recognition particle 72",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srp72"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "tcf3",
        "symbol": "TCF3",
        "hgnc": "HGNC:11633",
        "name": "transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf3"
      },
      {
        "slug": "tcn2",
        "symbol": "TCN2",
        "hgnc": "HGNC:11653",
        "name": "transcobalamin 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tcn2"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tnfrsf9",
        "symbol": "TNFRSF9",
        "hgnc": "HGNC:11924",
        "name": "TNF receptor superfamily member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf9"
      },
      {
        "slug": "ube2t",
        "symbol": "UBE2T",
        "hgnc": "HGNC:25009",
        "name": "ubiquitin conjugating enzyme E2 T",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2t"
      },
      {
        "slug": "zbtb16",
        "symbol": "ZBTB16",
        "hgnc": "HGNC:12930",
        "name": "zinc finger and BTB domain containing 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb16"
      },
      {
        "slug": "amn",
        "symbol": "AMN",
        "hgnc": "HGNC:14604",
        "name": "amnion associated transmembrane protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amn"
      },
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "ca2",
        "symbol": "CA2",
        "hgnc": "HGNC:1373",
        "name": "carbonic anhydrase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca2"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "cbl",
        "symbol": "CBL",
        "hgnc": "HGNC:1541",
        "name": "Cbl proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbl"
      },
      {
        "slug": "cd27",
        "symbol": "CD27",
        "hgnc": "HGNC:11922",
        "name": "CD27 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd27"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "hgnc": "HGNC:7067",
        "name": "class II major histocompatibility complex transactivator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciita"
      },
      {
        "slug": "cog6",
        "symbol": "COG6",
        "hgnc": "HGNC:18621",
        "name": "component of oligomeric golgi complex 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog6"
      },
      {
        "slug": "cubn",
        "symbol": "CUBN",
        "hgnc": "HGNC:2548",
        "name": "cubilin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cubn"
      },
      {
        "slug": "efl1",
        "symbol": "EFL1",
        "hgnc": "HGNC:25789",
        "name": "elongation factor like GTPase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efl1"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "hgnc": "HGNC:18873",
        "name": "interferon induced with helicase C domain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifih1"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "lmbrd1",
        "symbol": "LMBRD1",
        "hgnc": "HGNC:23038",
        "name": "LMBR1 domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbrd1"
      },
      {
        "slug": "lrba",
        "symbol": "LRBA",
        "hgnc": "HGNC:1742",
        "name": "LPS responsive beige-like anchor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrba"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "man2b1",
        "symbol": "MAN2B1",
        "hgnc": "HGNC:6826",
        "name": "mannosidase alpha class 2B member 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/man2b1"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "mtrr",
        "symbol": "MTRR",
        "hgnc": "HGNC:7473",
        "name": "5-methyltetrahydrofolate-homocysteine methyltransferase reductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtrr"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "rfxank",
        "symbol": "RFXANK",
        "hgnc": "HGNC:9987",
        "name": "regulatory factor X associated ankyrin containing protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxank"
      },
      {
        "slug": "rfxap",
        "symbol": "RFXAP",
        "hgnc": "HGNC:9988",
        "name": "regulatory factor X associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxap"
      },
      {
        "slug": "rpa1",
        "symbol": "RPA1",
        "hgnc": "HGNC:10289",
        "name": "replication protein A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpa1"
      },
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      },
      {
        "slug": "samd9l",
        "symbol": "SAMD9L",
        "hgnc": "HGNC:1349",
        "name": "sterile alpha motif domain containing 9 like",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/samd9l"
      },
      {
        "slug": "slc46a1",
        "symbol": "SLC46A1",
        "hgnc": "HGNC:30521",
        "name": "solute carrier family 46 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc46a1"
      },
      {
        "slug": "sp110",
        "symbol": "SP110",
        "hgnc": "HGNC:5401",
        "name": "SP110 nuclear body protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sp110"
      },
      {
        "slug": "srsf2",
        "symbol": "SRSF2",
        "hgnc": "HGNC:10783",
        "name": "serine and arginine rich splicing factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srsf2"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "acbd6",
        "symbol": "ACBD6",
        "hgnc": "HGNC:23339",
        "name": "acyl-CoA binding domain containing 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acbd6"
      },
      {
        "slug": "acp5",
        "symbol": "ACP5",
        "hgnc": "HGNC:124",
        "name": "acid phosphatase 5, tartrate resistant",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acp5"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "havcr2",
        "symbol": "HAVCR2",
        "hgnc": "HGNC:18437",
        "name": "hepatitis A virus cellular receptor 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/havcr2"
      },
      {
        "slug": "sf3b1",
        "symbol": "SF3B1",
        "hgnc": "HGNC:10768",
        "name": "splicing factor 3b subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b1"
      },
      {
        "slug": "acd",
        "symbol": "ACD",
        "hgnc": "HGNC:25070",
        "name": "ACD shelterin complex subunit and telomerase recruitment factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acd"
      },
      {
        "slug": "aptx",
        "symbol": "APTX",
        "hgnc": "HGNC:15984",
        "name": "aprataxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aptx"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "bach2",
        "symbol": "BACH2",
        "hgnc": "HGNC:14078",
        "name": "BACH transcriptional regulator 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bach2"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "dhfr",
        "symbol": "DHFR",
        "hgnc": "HGNC:2861",
        "name": "dihydrofolate reductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhfr"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "hgnc": "HGNC:3582",
        "name": "FA complementation group A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanca"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "hgnc": "HGNC:3586",
        "name": "FA complementation group E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fance"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "ivd",
        "symbol": "IVD",
        "hgnc": "HGNC:6186",
        "name": "isovaleryl-CoA dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivd"
      },
      {
        "slug": "mmaa",
        "symbol": "MMAA",
        "hgnc": "HGNC:18871",
        "name": "metabolism of cobalamin associated A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmaa"
      },
      {
        "slug": "mmab",
        "symbol": "MMAB",
        "hgnc": "HGNC:19331",
        "name": "metabolism of cobalamin associated B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmab"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "pcca",
        "symbol": "PCCA",
        "hgnc": "HGNC:8653",
        "name": "propionyl-CoA carboxylase subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcca"
      },
      {
        "slug": "pccb",
        "symbol": "PCCB",
        "hgnc": "HGNC:8654",
        "name": "propionyl-CoA carboxylase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pccb"
      },
      {
        "slug": "pstpip1",
        "symbol": "PSTPIP1",
        "hgnc": "HGNC:9580",
        "name": "proline-serine-threonine phosphatase interacting protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pstpip1"
      },
      {
        "slug": "rnaseh2a",
        "symbol": "RNASEH2A",
        "hgnc": "HGNC:18518",
        "name": "ribonuclease H2 subunit A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2a"
      },
      {
        "slug": "samd9",
        "symbol": "SAMD9",
        "hgnc": "HGNC:1348",
        "name": "sterile alpha motif domain containing 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samd9"
      },
      {
        "slug": "srp54",
        "symbol": "SRP54",
        "hgnc": "HGNC:11301",
        "name": "signal recognition particle 54",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srp54"
      },
      {
        "slug": "taldo1",
        "symbol": "TALDO1",
        "hgnc": "HGNC:11559",
        "name": "transaldolase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taldo1"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "tnfrsf4",
        "symbol": "TNFRSF4",
        "hgnc": "HGNC:11918",
        "name": "TNF receptor superfamily member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf4"
      },
      {
        "slug": "tnfsf11",
        "symbol": "TNFSF11",
        "hgnc": "HGNC:11926",
        "name": "TNF superfamily member 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf11"
      },
      {
        "slug": "wrap53",
        "symbol": "WRAP53",
        "hgnc": "HGNC:25522",
        "name": "WD repeat containing antisense to TP53",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrap53"
      }
    ]
  }
}