{
  "url": "https://dantelabs.com/traits/nuclear-cataract",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "nuclear-cataract",
    "id": "HP:0100018",
    "name": "Yellowish cloudy center of lens",
    "label": "Nuclear cataract",
    "definition": "A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.",
    "synonyms": [
      "Yellowish cloudy centre of lens"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "zonular-cataract",
        "name": "Zonular cataract",
        "url": "https://dantelabs.com/traits/zonular-cataract"
      }
    ],
    "narrower": [
      {
        "slug": "aculeiform-cataract",
        "name": "Aculeiform cataract",
        "genes": 1,
        "url": "https://dantelabs.com/traits/aculeiform-cataract"
      },
      {
        "slug": "diffuse-nuclear-cataract",
        "name": "Diffuse nuclear cataract",
        "genes": 1,
        "url": "https://dantelabs.com/traits/diffuse-nuclear-cataract"
      },
      {
        "slug": "nuclear-punctate-cataract",
        "name": "Nuclear punctate cataract",
        "genes": 0,
        "url": "https://dantelabs.com/traits/nuclear-punctate-cataract"
      }
    ],
    "genes": [
      {
        "slug": "cryba1",
        "symbol": "CRYBA1",
        "hgnc": "HGNC:2394",
        "name": "crystallin beta A1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cryba1"
      },
      {
        "slug": "cryba4",
        "symbol": "CRYBA4",
        "hgnc": "HGNC:2396",
        "name": "crystallin beta A4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cryba4"
      },
      {
        "slug": "crybb3",
        "symbol": "CRYBB3",
        "hgnc": "HGNC:2400",
        "name": "crystallin beta B3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crybb3"
      },
      {
        "slug": "crygs",
        "symbol": "CRYGS",
        "hgnc": "HGNC:2417",
        "name": "crystallin gamma S",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crygs"
      },
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "nhs",
        "symbol": "NHS",
        "hgnc": "HGNC:7820",
        "name": "NHS actin remodeling regulator",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nhs"
      },
      {
        "slug": "slc2a1",
        "symbol": "SLC2A1",
        "hgnc": "HGNC:11005",
        "name": "solute carrier family 2 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a1"
      },
      {
        "slug": "ubap1l",
        "symbol": "UBAP1L",
        "hgnc": "HGNC:40028",
        "name": "ubiquitin associated protein 1 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap1l"
      },
      {
        "slug": "efemp1",
        "symbol": "EFEMP1",
        "hgnc": "HGNC:3218",
        "name": "EGF-like fibulin extracellular matrix protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp1"
      },
      {
        "slug": "galk1",
        "symbol": "GALK1",
        "hgnc": "HGNC:4118",
        "name": "galactokinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galk1"
      },
      {
        "slug": "mvk",
        "symbol": "MVK",
        "hgnc": "HGNC:7530",
        "name": "mevalonate kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mvk"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "impg2",
        "symbol": "IMPG2",
        "hgnc": "HGNC:18362",
        "name": "interphotoreceptor matrix proteoglycan 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/impg2"
      },
      {
        "slug": "lim2",
        "symbol": "LIM2",
        "hgnc": "HGNC:6610",
        "name": "lens intrinsic membrane protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lim2"
      },
      {
        "slug": "nr2e3",
        "symbol": "NR2E3",
        "hgnc": "HGNC:7974",
        "name": "nuclear receptor subfamily 2 group E member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr2e3"
      },
      {
        "slug": "znf408",
        "symbol": "ZNF408",
        "hgnc": "HGNC:20041",
        "name": "zinc finger protein 408",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf408"
      },
      {
        "slug": "prg4",
        "symbol": "PRG4",
        "hgnc": "HGNC:9364",
        "name": "proteoglycan 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prg4"
      },
      {
        "slug": "bfsp1",
        "symbol": "BFSP1",
        "hgnc": "HGNC:1040",
        "name": "beaded filament structural protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bfsp1"
      },
      {
        "slug": "cfap410",
        "symbol": "CFAP410",
        "hgnc": "HGNC:1260",
        "name": "cilia and flagella associated protein 410",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap410"
      },
      {
        "slug": "chmp4b",
        "symbol": "CHMP4B",
        "hgnc": "HGNC:16171",
        "name": "charged multivesicular body protein 4B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chmp4b"
      },
      {
        "slug": "crybb1",
        "symbol": "CRYBB1",
        "hgnc": "HGNC:2397",
        "name": "crystallin beta B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crybb1"
      },
      {
        "slug": "crygc",
        "symbol": "CRYGC",
        "hgnc": "HGNC:2410",
        "name": "crystallin gamma C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crygc"
      },
      {
        "slug": "ftl",
        "symbol": "FTL",
        "hgnc": "HGNC:3999",
        "name": "ferritin light chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ftl"
      },
      {
        "slug": "fyco1",
        "symbol": "FYCO1",
        "hgnc": "HGNC:14673",
        "name": "FYVE and coiled-coil domain autophagy adaptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fyco1"
      },
      {
        "slug": "hsf4",
        "symbol": "HSF4",
        "hgnc": "HGNC:5227",
        "name": "heat shock transcription factor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsf4"
      },
      {
        "slug": "mip",
        "symbol": "MIP",
        "hgnc": "HGNC:7103",
        "name": "major intrinsic protein of lens fiber",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mip"
      },
      {
        "slug": "wfs1",
        "symbol": "WFS1",
        "hgnc": "HGNC:12762",
        "name": "wolframin ER transmembrane glycoprotein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wfs1"
      }
    ]
  }
}