{
  "url": "https://dantelabs.com/traits/menorrhagia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "menorrhagia",
    "id": "HP:0000132",
    "name": "Abnormally heavy bleeding during menstruation",
    "label": "Menorrhagia",
    "definition": "Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.",
    "synonyms": [
      "Abnormally heavy periods",
      "Hypermenorrhea"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-menstrual-cycle",
        "name": "Abnormality of the menstrual cycle",
        "url": "https://dantelabs.com/traits/abnormality-of-the-menstrual-cycle"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "apold1",
        "symbol": "APOLD1",
        "hgnc": "HGNC:25268",
        "name": "apolipoprotein L domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apold1"
      },
      {
        "slug": "dtnbp1",
        "symbol": "DTNBP1",
        "hgnc": "HGNC:17328",
        "name": "dystrobrevin binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dtnbp1"
      },
      {
        "slug": "f7",
        "symbol": "F7",
        "hgnc": "HGNC:3544",
        "name": "coagulation factor VII",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f7"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "hgnc": "HGNC:3749",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fli1"
      },
      {
        "slug": "fyb1",
        "symbol": "FYB1",
        "hgnc": "HGNC:4036",
        "name": "FYN binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fyb1"
      },
      {
        "slug": "gne",
        "symbol": "GNE",
        "hgnc": "HGNC:23657",
        "name": "glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gne"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "hps4",
        "symbol": "HPS4",
        "hgnc": "HGNC:15844",
        "name": "HPS4 biogenesis of lysosomal organelles complex 3 subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps4"
      },
      {
        "slug": "itgb3",
        "symbol": "ITGB3",
        "hgnc": "HGNC:6156",
        "name": "integrin subunit beta 3",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/itgb3"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "prkacg",
        "symbol": "PRKACG",
        "hgnc": "HGNC:9382",
        "name": "protein kinase cAMP-activated catalytic subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkacg"
      },
      {
        "slug": "ptprj",
        "symbol": "PTPRJ",
        "hgnc": "HGNC:9673",
        "name": "protein tyrosine phosphatase receptor type J",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprj"
      },
      {
        "slug": "rasgrp2",
        "symbol": "RASGRP2",
        "hgnc": "HGNC:9879",
        "name": "RAS guanyl releasing protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasgrp2"
      },
      {
        "slug": "tpm4",
        "symbol": "TPM4",
        "hgnc": "HGNC:12013",
        "name": "tropomyosin 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm4"
      },
      {
        "slug": "bloc1s3",
        "symbol": "BLOC1S3",
        "hgnc": "HGNC:20914",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bloc1s3"
      },
      {
        "slug": "bloc1s5",
        "symbol": "BLOC1S5",
        "hgnc": "HGNC:18561",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bloc1s5"
      },
      {
        "slug": "f11",
        "symbol": "F11",
        "hgnc": "HGNC:3529",
        "name": "coagulation factor XI",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f11"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "gp9",
        "symbol": "GP9",
        "hgnc": "HGNC:4444",
        "name": "glycoprotein IX platelet",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp9"
      },
      {
        "slug": "hps5",
        "symbol": "HPS5",
        "hgnc": "HGNC:17022",
        "name": "HPS5 biogenesis of lysosomal organelles complex 2 subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps5"
      },
      {
        "slug": "myh9",
        "symbol": "MYH9",
        "hgnc": "HGNC:7579",
        "name": "myosin heavy chain 9",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myh9"
      },
      {
        "slug": "prlr",
        "symbol": "PRLR",
        "hgnc": "HGNC:9446",
        "name": "prolactin receptor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prlr"
      },
      {
        "slug": "serpine1",
        "symbol": "SERPINE1",
        "hgnc": "HGNC:8583",
        "name": "serpin family E member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/serpine1"
      },
      {
        "slug": "ano6",
        "symbol": "ANO6",
        "hgnc": "HGNC:25240",
        "name": "anoctamin 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano6"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "hgnc": "HGNC:2876",
        "name": "diaphanous related formin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/diaph1"
      },
      {
        "slug": "f10",
        "symbol": "F10",
        "hgnc": "HGNC:3528",
        "name": "coagulation factor X",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "f13a1",
        "symbol": "F13A1",
        "hgnc": "HGNC:3531",
        "name": "coagulation factor XIII A chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13a1"
      },
      {
        "slug": "f13b",
        "symbol": "F13B",
        "hgnc": "HGNC:3534",
        "name": "coagulation factor XIII B chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13b"
      },
      {
        "slug": "f2",
        "symbol": "F2",
        "hgnc": "HGNC:3535",
        "name": "coagulation factor II, thrombin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "lman1",
        "symbol": "LMAN1",
        "hgnc": "HGNC:6631",
        "name": "lectin, mannose binding 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lman1"
      },
      {
        "slug": "mcfd2",
        "symbol": "MCFD2",
        "hgnc": "HGNC:18451",
        "name": "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mcfd2"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vkorc1"
      },
      {
        "slug": "ppp2r5c",
        "symbol": "PPP2R5C",
        "hgnc": "HGNC:9311",
        "name": "protein phosphatase 2 regulatory subunit B'gamma",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r5c"
      },
      {
        "slug": "gp6",
        "symbol": "GP6",
        "hgnc": "HGNC:14388",
        "name": "glycoprotein VI platelet",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp6"
      },
      {
        "slug": "nbeal2",
        "symbol": "NBEAL2",
        "hgnc": "HGNC:31928",
        "name": "neurobeachin like 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nbeal2"
      },
      {
        "slug": "plau",
        "symbol": "PLAU",
        "hgnc": "HGNC:9052",
        "name": "plasminogen activator, urokinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plau"
      },
      {
        "slug": "slfn14",
        "symbol": "SLFN14",
        "hgnc": "HGNC:32689",
        "name": "schlafen family member 14",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slfn14"
      },
      {
        "slug": "vwf",
        "symbol": "VWF",
        "hgnc": "HGNC:12726",
        "name": "von Willebrand factor",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/vwf"
      }
    ]
  }
}