{
  "url": "https://dantelabs.com/traits/lacunar-stroke",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "lacunar-stroke",
    "id": "HP:0032325",
    "name": "Lacunar stroke",
    "definition": "A stroke related to a small infarct (2-20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, that is presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "ischemic-stroke",
        "name": "Ischemic stroke",
        "url": "https://dantelabs.com/traits/ischemic-stroke"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "arhgef15",
        "symbol": "ARHGEF15",
        "hgnc": "HGNC:15590",
        "name": "Rho guanine nucleotide exchange factor 15",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef15"
      },
      {
        "slug": "htra1",
        "symbol": "HTRA1",
        "hgnc": "HGNC:9476",
        "name": "HtrA serine peptidase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/htra1"
      },
      {
        "slug": "naga",
        "symbol": "NAGA",
        "hgnc": "HGNC:7631",
        "name": "alpha-N-acetylgalactosaminidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naga"
      },
      {
        "slug": "nit1",
        "symbol": "NIT1",
        "hgnc": "HGNC:7828",
        "name": "nitrilase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nit1"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "col4a1",
        "symbol": "COL4A1",
        "hgnc": "HGNC:2202",
        "name": "collagen type IV alpha 1 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col4a1"
      },
      {
        "slug": "colgalt1",
        "symbol": "COLGALT1",
        "hgnc": "HGNC:26182",
        "name": "collagen beta(1-O)galactosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/colgalt1"
      },
      {
        "slug": "pik3c2a",
        "symbol": "PIK3C2A",
        "hgnc": "HGNC:8971",
        "name": "phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3c2a"
      }
    ]
  }
}