{
  "url": "https://dantelabs.com/traits/inverted-nipples",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "inverted-nipples",
    "id": "HP:0003186",
    "name": "Inverted nipples",
    "definition": "The presence of nipples that instead of pointing outward are retracted inwards.",
    "synonyms": [
      "Invaginated nipples"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-breast",
        "name": "Abnormality of the breast",
        "url": "https://dantelabs.com/traits/abnormality-of-the-breast"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nipple-morphology",
        "name": "Abnormality of the nipple",
        "url": "https://dantelabs.com/traits/abnormal-nipple-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "alg12",
        "symbol": "ALG12",
        "hgnc": "HGNC:19358",
        "name": "ALG12 alpha-1,6-mannosyltransferase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alg12"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "amotl1",
        "symbol": "AMOTL1",
        "hgnc": "HGNC:17811",
        "name": "angiomotin like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amotl1"
      },
      {
        "slug": "atxn7l3",
        "symbol": "ATXN7L3",
        "hgnc": "HGNC:25416",
        "name": "ataxin 7 like 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn7l3"
      },
      {
        "slug": "c18orf32",
        "symbol": "C18orf32",
        "hgnc": "HGNC:31690",
        "name": "chromosome 18 open reading frame 32",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c18orf32"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "eif4a2",
        "symbol": "EIF4A2",
        "hgnc": "HGNC:3284",
        "name": "eukaryotic translation initiation factor 4A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4a2"
      },
      {
        "slug": "intu",
        "symbol": "INTU",
        "hgnc": "HGNC:29239",
        "name": "inturned planar cell polarity protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/intu"
      },
      {
        "slug": "nsun2",
        "symbol": "NSUN2",
        "hgnc": "HGNC:25994",
        "name": "NOP2/Sun RNA methyltransferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsun2"
      },
      {
        "slug": "pex3",
        "symbol": "PEX3",
        "hgnc": "HGNC:8858",
        "name": "peroxisomal biogenesis factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex3"
      },
      {
        "slug": "tcf20",
        "symbol": "TCF20",
        "hgnc": "HGNC:11631",
        "name": "transcription factor 20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf20"
      },
      {
        "slug": "alg11",
        "symbol": "ALG11",
        "hgnc": "HGNC:32456",
        "name": "ALG11 alpha-1,2-mannosyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alg11"
      },
      {
        "slug": "alg2",
        "symbol": "ALG2",
        "hgnc": "HGNC:23159",
        "name": "ALG2 alpha-1,3/1,6-mannosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg2"
      },
      {
        "slug": "def6",
        "symbol": "DEF6",
        "hgnc": "HGNC:2760",
        "name": "DEF6 guanine nucleotide exchange factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/def6"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "ezh2",
        "symbol": "EZH2",
        "hgnc": "HGNC:3527",
        "name": "enhancer of zeste 2 polycomb repressive complex 2 subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ezh2"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "man1b1",
        "symbol": "MAN1B1",
        "hgnc": "HGNC:6823",
        "name": "mannosidase alpha class 1B member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/man1b1"
      },
      {
        "slug": "pigt",
        "symbol": "PIGT",
        "hgnc": "HGNC:14938",
        "name": "phosphatidylinositol glycan anchor biosynthesis class T",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pigt"
      },
      {
        "slug": "pmm2",
        "symbol": "PMM2",
        "hgnc": "HGNC:9115",
        "name": "phosphomannomutase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmm2"
      },
      {
        "slug": "rft1",
        "symbol": "RFT1",
        "hgnc": "HGNC:30220",
        "name": "RFT1 glycolipid translocator homolog",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rft1"
      },
      {
        "slug": "alg3",
        "symbol": "ALG3",
        "hgnc": "HGNC:23056",
        "name": "ALG3 alpha-1,3- mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg3"
      },
      {
        "slug": "alg8",
        "symbol": "ALG8",
        "hgnc": "HGNC:23161",
        "name": "ALG8 alpha-1,3-glucosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg8"
      },
      {
        "slug": "atn1",
        "symbol": "ATN1",
        "hgnc": "HGNC:3033",
        "name": "atrophin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atn1"
      },
      {
        "slug": "b4galt1",
        "symbol": "B4GALT1",
        "hgnc": "HGNC:924",
        "name": "beta-1,4-galactosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4galt1"
      },
      {
        "slug": "bicra",
        "symbol": "BICRA",
        "hgnc": "HGNC:4332",
        "name": "BRD4 interacting chromatin remodeling complex associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicra"
      },
      {
        "slug": "dlk1",
        "symbol": "DLK1",
        "hgnc": "HGNC:2907",
        "name": "delta like non-canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlk1"
      },
      {
        "slug": "dpagt1",
        "symbol": "DPAGT1",
        "hgnc": "HGNC:2995",
        "name": "dolichyl-phosphate N-acetylglucosaminephosphotransferase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dpagt1"
      },
      {
        "slug": "dpm1",
        "symbol": "DPM1",
        "hgnc": "HGNC:3005",
        "name": "dolichyl-phosphate mannosyltransferase subunit 1, catalytic",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpm1"
      },
      {
        "slug": "jarid2",
        "symbol": "JARID2",
        "hgnc": "HGNC:6196",
        "name": "jumonji and AT-rich interaction domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jarid2"
      },
      {
        "slug": "kat6a",
        "symbol": "KAT6A",
        "hgnc": "HGNC:13013",
        "name": "lysine acetyltransferase 6A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kat6a"
      },
      {
        "slug": "kmt2b",
        "symbol": "KMT2B",
        "hgnc": "HGNC:15840",
        "name": "lysine methyltransferase 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2b"
      },
      {
        "slug": "lef1",
        "symbol": "LEF1",
        "hgnc": "HGNC:6551",
        "name": "lymphoid enhancer binding factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lef1"
      },
      {
        "slug": "meg3",
        "symbol": "MEG3",
        "hgnc": "HGNC:14575",
        "name": "maternally expressed 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meg3"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mgat2"
      },
      {
        "slug": "msl2",
        "symbol": "MSL2",
        "hgnc": "HGNC:25544",
        "name": "MSL complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl2"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "rere",
        "symbol": "RERE",
        "hgnc": "HGNC:9965",
        "name": "arginine-glutamic acid dipeptide repeats",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rere"
      },
      {
        "slug": "rtl1",
        "symbol": "RTL1",
        "hgnc": "HGNC:14665",
        "name": "retrotransposon Gag like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtl1"
      },
      {
        "slug": "set",
        "symbol": "SET",
        "hgnc": "HGNC:10760",
        "name": "SET nuclear proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/set"
      },
      {
        "slug": "slc35a2",
        "symbol": "SLC35A2",
        "hgnc": "HGNC:11022",
        "name": "solute carrier family 35 member A2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a2"
      },
      {
        "slug": "slc4a10",
        "symbol": "SLC4A10",
        "hgnc": "HGNC:13811",
        "name": "solute carrier family 4 member 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a10"
      },
      {
        "slug": "sox6",
        "symbol": "SOX6",
        "hgnc": "HGNC:16421",
        "name": "SRY-box transcription factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox6"
      },
      {
        "slug": "srd5a3",
        "symbol": "SRD5A3",
        "hgnc": "HGNC:25812",
        "name": "steroid 5 alpha-reductase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srd5a3"
      },
      {
        "slug": "stt3a",
        "symbol": "STT3A",
        "hgnc": "HGNC:6172",
        "name": "STT3 oligosaccharyltransferase complex catalytic subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stt3a"
      },
      {
        "slug": "traf7",
        "symbol": "TRAF7",
        "hgnc": "HGNC:20456",
        "name": "TNF receptor associated factor 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf7"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "wac",
        "symbol": "WAC",
        "hgnc": "HGNC:17327",
        "name": "WW domain containing adaptor with coiled-coil",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wac"
      },
      {
        "slug": "wasf1",
        "symbol": "WASF1",
        "hgnc": "HGNC:12732",
        "name": "WASP family member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wasf1"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "acox1",
        "symbol": "ACOX1",
        "hgnc": "HGNC:119",
        "name": "acyl-CoA oxidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acox1"
      },
      {
        "slug": "cog7",
        "symbol": "COG7",
        "hgnc": "HGNC:18622",
        "name": "component of oligomeric golgi complex 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog7"
      },
      {
        "slug": "slc25a46",
        "symbol": "SLC25A46",
        "hgnc": "HGNC:25198",
        "name": "solute carrier family 25 member 46",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a46"
      },
      {
        "slug": "tbx3",
        "symbol": "TBX3",
        "hgnc": "HGNC:11602",
        "name": "T-box transcription factor 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx3"
      }
    ]
  }
}