{
  "url": "https://dantelabs.com/traits/increased-circulating-hemoglobin-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-circulating-hemoglobin-concentration",
    "id": "HP:0001900",
    "name": "Increased circulating hemoglobin concentration",
    "definition": "Concentration of hemoglobin in the blood circulation above the upper limit of normal.",
    "synonyms": [
      "Increased haemoglobin",
      "Increased haemoglobin concentration",
      "Increased Hb",
      "Increased Hb concentration",
      "Increased hemoglobin",
      "Increased hemoglobin concentration"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hemoglobin-concentration",
        "name": "Abnormal hemoglobin concentration",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin-concentration"
      },
      {
        "slug": "polycythemia",
        "name": "Increased red blood cells",
        "url": "https://dantelabs.com/traits/polycythemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bpgm",
        "symbol": "BPGM",
        "hgnc": "HGNC:1093",
        "name": "bisphosphoglycerate mutase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bpgm"
      },
      {
        "slug": "epas1",
        "symbol": "EPAS1",
        "hgnc": "HGNC:3374",
        "name": "endothelial PAS domain protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epas1"
      },
      {
        "slug": "epor",
        "symbol": "EPOR",
        "hgnc": "HGNC:3416",
        "name": "erythropoietin receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epor"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vhl"
      },
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "egln1",
        "symbol": "EGLN1",
        "hgnc": "HGNC:1232",
        "name": "egl-9 family hypoxia inducible factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/egln1"
      },
      {
        "slug": "epo",
        "symbol": "EPO",
        "hgnc": "HGNC:3415",
        "name": "erythropoietin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epo"
      },
      {
        "slug": "hba1",
        "symbol": "HBA1",
        "hgnc": "HGNC:4823",
        "name": "hemoglobin subunit alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hba1"
      },
      {
        "slug": "hba2",
        "symbol": "HBA2",
        "hgnc": "HGNC:4824",
        "name": "hemoglobin subunit alpha 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hba2"
      }
    ]
  }
}