{
  "url": "https://dantelabs.com/traits/hypogranulosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypogranulosis",
    "id": "HP:0025816",
    "name": "Hypogranulosis",
    "definition": "The height (thickness) of the stratum granulosum of the epidermis (granular layer) is below the lower limit of normal but the stratum granulosum is visible.",
    "synonyms": [
      "Diminished granular layer",
      "Reduced granular layer"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-epidermis-stratum-granulosum-morphology",
        "name": "Abnormal epidermis stratum granulosum morphology",
        "url": "https://dantelabs.com/traits/abnormal-epidermis-stratum-granulosum-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      }
    ]
  }
}