{
  "url": "https://dantelabs.com/traits/hyperchloremia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hyperchloremia",
    "id": "HP:0011423",
    "name": "Hyperchloremia",
    "definition": "The concentration of chloride in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated chloride concentration",
      "Elevated chloride level",
      "Elevated chloride level in blood",
      "Increased chloride concentration",
      "Increased chloride level",
      "Increased chloride level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-chloride-concentration",
        "name": "Abnormal circulating chloride concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-chloride-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atp6v1b1",
        "symbol": "ATP6V1B1",
        "hgnc": "HGNC:853",
        "name": "ATPase H+ transporting V1 subunit B1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b1"
      },
      {
        "slug": "wnk1",
        "symbol": "WNK1",
        "hgnc": "HGNC:14540",
        "name": "WNK lysine deficient protein kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnk1"
      },
      {
        "slug": "cul3",
        "symbol": "CUL3",
        "hgnc": "HGNC:2553",
        "name": "cullin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul3"
      },
      {
        "slug": "klhl3",
        "symbol": "KLHL3",
        "hgnc": "HGNC:6354",
        "name": "kelch like family member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl3"
      },
      {
        "slug": "wnk4",
        "symbol": "WNK4",
        "hgnc": "HGNC:14544",
        "name": "WNK lysine deficient protein kinase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnk4"
      }
    ]
  }
}