{
  "url": "https://dantelabs.com/traits/hamartoma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hamartoma",
    "id": "HP:0010566",
    "name": "Hamartoma",
    "definition": "A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma.",
    "synonyms": [],
    "systems": [
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "neoplasm-by-histology",
        "name": "Neoplasm by histology",
        "url": "https://dantelabs.com/traits/neoplasm-by-histology"
      }
    ],
    "narrower": [
      {
        "slug": "hamartomatous-polyposis",
        "name": "Hamartomatous polyposis",
        "genes": 5,
        "url": "https://dantelabs.com/traits/hamartomatous-polyposis"
      },
      {
        "slug": "odontoma",
        "name": "Odontoma",
        "genes": 2,
        "url": "https://dantelabs.com/traits/odontoma"
      },
      {
        "slug": "renal-hamartoma",
        "name": "Renal hamartoma",
        "genes": 2,
        "url": "https://dantelabs.com/traits/renal-hamartoma"
      },
      {
        "slug": "cerebral-hamartoma",
        "name": "Cerebral hamartoma",
        "genes": 0,
        "url": "https://dantelabs.com/traits/cerebral-hamartoma"
      },
      {
        "slug": "hamartoma-of-the-orbital-region",
        "name": "Hamartoma of the orbital region",
        "genes": 0,
        "url": "https://dantelabs.com/traits/hamartoma-of-the-orbital-region"
      }
    ],
    "genes": [
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "nek9",
        "symbol": "NEK9",
        "hgnc": "HGNC:18591",
        "name": "NIMA related kinase 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek9"
      },
      {
        "slug": "tctn3",
        "symbol": "TCTN3",
        "hgnc": "HGNC:24519",
        "name": "tectonic family member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn3"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "acvr1",
        "symbol": "ACVR1",
        "hgnc": "HGNC:171",
        "name": "activin A receptor type 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr1"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "hgnc": "HGNC:16783",
        "name": "cell division cycle 73",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc73"
      },
      {
        "slug": "dync2li1",
        "symbol": "DYNC2LI1",
        "hgnc": "HGNC:24595",
        "name": "dynein cytoplasmic 2 light intermediate chain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2li1"
      },
      {
        "slug": "klln",
        "symbol": "KLLN",
        "hgnc": "HGNC:37212",
        "name": "killin, p53 regulated DNA replication inhibitor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klln"
      },
      {
        "slug": "tbc1d32",
        "symbol": "TBC1D32",
        "hgnc": "HGNC:21485",
        "name": "TBC1 domain family member 32",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d32"
      },
      {
        "slug": "tfap2a",
        "symbol": "TFAP2A",
        "hgnc": "HGNC:11742",
        "name": "transcription factor AP-2 alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfap2a"
      }
    ]
  }
}