{
  "url": "https://dantelabs.com/traits/granuloma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "granuloma",
    "id": "HP:0032252",
    "name": "Granuloma",
    "definition": "A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-immune-system-morphology",
        "name": "Abnormal immune system morphology",
        "url": "https://dantelabs.com/traits/abnormal-immune-system-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "cutaneous-granuloma",
        "name": "Cutaneous granuloma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/cutaneous-granuloma"
      },
      {
        "slug": "eosinophilic-granuloma",
        "name": "Eosinophilic granuloma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/eosinophilic-granuloma"
      }
    ],
    "genes": [
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "cybc1",
        "symbol": "CYBC1",
        "hgnc": "HGNC:28672",
        "name": "cytochrome b-245 chaperone 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybc1"
      },
      {
        "slug": "dnase2",
        "symbol": "DNASE2",
        "hgnc": "HGNC:2960",
        "name": "deoxyribonuclease 2, lysosomal",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase2"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "irf8",
        "symbol": "IRF8",
        "hgnc": "HGNC:5358",
        "name": "interferon regulatory factor 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf8"
      },
      {
        "slug": "otulin",
        "symbol": "OTULIN",
        "hgnc": "HGNC:25118",
        "name": "OTU deubiquitinase with linear linkage specificity",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otulin"
      },
      {
        "slug": "pik3cg",
        "symbol": "PIK3CG",
        "hgnc": "HGNC:8978",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cg"
      },
      {
        "slug": "acp5",
        "symbol": "ACP5",
        "hgnc": "HGNC:124",
        "name": "acid phosphatase 5, tartrate resistant",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acp5"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      }
    ]
  }
}