{
  "url": "https://dantelabs.com/traits/elevated-transferrin-saturation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "elevated-transferrin-saturation",
    "id": "HP:0012463",
    "name": "Elevated transferrin saturation",
    "definition": "An above normal level of saturation of serum transferrin with iron.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-transferrin-saturation",
        "name": "Abnormal transferrin saturation",
        "url": "https://dantelabs.com/traits/abnormal-transferrin-saturation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fth1",
        "symbol": "FTH1",
        "hgnc": "HGNC:3976",
        "name": "ferritin heavy chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fth1"
      },
      {
        "slug": "hamp",
        "symbol": "HAMP",
        "hgnc": "HGNC:15598",
        "name": "hepcidin antimicrobial peptide",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hamp"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "slc25a38",
        "symbol": "SLC25A38",
        "hgnc": "HGNC:26054",
        "name": "solute carrier family 25 member 38",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a38"
      },
      {
        "slug": "steap3",
        "symbol": "STEAP3",
        "hgnc": "HGNC:24592",
        "name": "STEAP3 metalloreductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/steap3"
      },
      {
        "slug": "tfr2",
        "symbol": "TFR2",
        "hgnc": "HGNC:11762",
        "name": "transferrin receptor 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tfr2"
      },
      {
        "slug": "bmp6",
        "symbol": "BMP6",
        "hgnc": "HGNC:1073",
        "name": "bone morphogenetic protein 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bmp6"
      },
      {
        "slug": "hfe",
        "symbol": "HFE",
        "hgnc": "HGNC:4886",
        "name": "homeostatic iron regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hfe"
      },
      {
        "slug": "hjv",
        "symbol": "HJV",
        "hgnc": "HGNC:4887",
        "name": "hemojuvelin BMP co-receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hjv"
      },
      {
        "slug": "pklr",
        "symbol": "PKLR",
        "hgnc": "HGNC:9020",
        "name": "pyruvate kinase L/R",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pklr"
      },
      {
        "slug": "slc40a1",
        "symbol": "SLC40A1",
        "hgnc": "HGNC:10909",
        "name": "solute carrier family 40 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc40a1"
      }
    ]
  }
}