{
  "url": "https://dantelabs.com/traits/dentinogenesis-imperfecta",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "dentinogenesis-imperfecta",
    "id": "HP:0000703",
    "name": "Dentinogenesis imperfecta",
    "definition": "Developmental dysplasia of dentin.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-dentin-morphology",
        "name": "Abnormal dentin",
        "url": "https://dantelabs.com/traits/abnormal-dentin-morphology"
      },
      {
        "slug": "abnormal-odontoid-tissue-morphology",
        "name": "Abnormal odontoid tissue morphology",
        "url": "https://dantelabs.com/traits/abnormal-odontoid-tissue-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "odontodysplasia",
        "name": "Odontodysplasia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/odontodysplasia"
      },
      {
        "slug": "dentinogenesis-imperfecta-limited-to-primary-teeth",
        "name": "Dentinogenesis imperfecta limited to primary teeth",
        "genes": 1,
        "url": "https://dantelabs.com/traits/dentinogenesis-imperfecta-limited-to-primary-teeth"
      }
    ],
    "genes": [
      {
        "slug": "mia3",
        "symbol": "MIA3",
        "hgnc": "HGNC:24008",
        "name": "MIA SH3 domain ER export factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mia3"
      },
      {
        "slug": "serpinh1",
        "symbol": "SERPINH1",
        "hgnc": "HGNC:1546",
        "name": "serpin family H member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinh1"
      },
      {
        "slug": "ppib",
        "symbol": "PPIB",
        "hgnc": "HGNC:9255",
        "name": "peptidylprolyl isomerase B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppib"
      },
      {
        "slug": "trip11",
        "symbol": "TRIP11",
        "hgnc": "HGNC:12305",
        "name": "thyroid hormone receptor interactor 11",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trip11"
      },
      {
        "slug": "p4hb",
        "symbol": "P4HB",
        "hgnc": "HGNC:8548",
        "name": "prolyl 4-hydroxylase subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/p4hb"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "hgnc": "HGNC:2197",
        "name": "collagen type I alpha 1 chain",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/col1a1"
      },
      {
        "slug": "col1a2",
        "symbol": "COL1A2",
        "hgnc": "HGNC:2198",
        "name": "collagen type I alpha 2 chain",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col1a2"
      },
      {
        "slug": "fkbp10",
        "symbol": "FKBP10",
        "hgnc": "HGNC:18169",
        "name": "FKBP prolyl isomerase 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp10"
      },
      {
        "slug": "dspp",
        "symbol": "DSPP",
        "hgnc": "HGNC:3054",
        "name": "dentin sialophosphoprotein",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dspp"
      },
      {
        "slug": "sec24d",
        "symbol": "SEC24D",
        "hgnc": "HGNC:10706",
        "name": "SEC24 homolog D, COPII component",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24d"
      },
      {
        "slug": "znf469",
        "symbol": "ZNF469",
        "hgnc": "HGNC:23216",
        "name": "zinc finger protein 469",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf469"
      }
    ]
  }
}