{
  "url": "https://dantelabs.com/traits/delayed-fine-motor-development",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "delayed-fine-motor-development",
    "id": "HP:0010862",
    "name": "Delayed fine motor development",
    "definition": "A type of motor delay characterized by a delay in acquiring the ability to control the fingers and hands.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "url": "https://dantelabs.com/traits/motor-delay"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "arid2",
        "symbol": "ARID2",
        "hgnc": "HGNC:18037",
        "name": "AT-rich interaction domain 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arid2"
      },
      {
        "slug": "auts2",
        "symbol": "AUTS2",
        "hgnc": "HGNC:14262",
        "name": "activator of transcription and developmental regulator AUTS2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/auts2"
      },
      {
        "slug": "cacna1g",
        "symbol": "CACNA1G",
        "hgnc": "HGNC:1394",
        "name": "calcium voltage-gated channel subunit alpha1 G",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1g"
      },
      {
        "slug": "cars1",
        "symbol": "CARS1",
        "hgnc": "HGNC:1493",
        "name": "cysteinyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cars1"
      },
      {
        "slug": "ccnk",
        "symbol": "CCNK",
        "hgnc": "HGNC:1596",
        "name": "cyclin K",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnk"
      },
      {
        "slug": "cdc40",
        "symbol": "CDC40",
        "hgnc": "HGNC:17350",
        "name": "cell division cycle 40",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc40"
      },
      {
        "slug": "cdh11",
        "symbol": "CDH11",
        "hgnc": "HGNC:1750",
        "name": "cadherin 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh11"
      },
      {
        "slug": "cit",
        "symbol": "CIT",
        "hgnc": "HGNC:1985",
        "name": "citron rho-interacting serine/threonine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cit"
      },
      {
        "slug": "clcn3",
        "symbol": "CLCN3",
        "hgnc": "HGNC:2021",
        "name": "Cl-/H+ antiporter 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcn3"
      },
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "creld1",
        "symbol": "CRELD1",
        "hgnc": "HGNC:14630",
        "name": "CRELD disulfide isomerase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/creld1"
      },
      {
        "slug": "ctnna2",
        "symbol": "CTNNA2",
        "hgnc": "HGNC:2510",
        "name": "catenin alpha 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnna2"
      },
      {
        "slug": "dand5",
        "symbol": "DAND5",
        "hgnc": "HGNC:26780",
        "name": "DAN domain BMP antagonist family member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dand5"
      },
      {
        "slug": "eif4a2",
        "symbol": "EIF4A2",
        "hgnc": "HGNC:3284",
        "name": "eukaryotic translation initiation factor 4A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4a2"
      },
      {
        "slug": "fastkd5",
        "symbol": "FASTKD5",
        "hgnc": "HGNC:25790",
        "name": "FASTK mitochondrial RNA regulator 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd5"
      },
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "fnip1",
        "symbol": "FNIP1",
        "hgnc": "HGNC:29418",
        "name": "folliculin interacting protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fnip1"
      },
      {
        "slug": "gria1",
        "symbol": "GRIA1",
        "hgnc": "HGNC:4571",
        "name": "glutamate ionotropic receptor AMPA type subunit 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gria1"
      },
      {
        "slug": "itpr1",
        "symbol": "ITPR1",
        "hgnc": "HGNC:6180",
        "name": "inositol 1,4,5-trisphosphate receptor type 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itpr1"
      },
      {
        "slug": "kat8",
        "symbol": "KAT8",
        "hgnc": "HGNC:17933",
        "name": "lysine acetyltransferase 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kat8"
      },
      {
        "slug": "kcnk4",
        "symbol": "KCNK4",
        "hgnc": "HGNC:6279",
        "name": "potassium two pore domain channel subfamily K member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk4"
      },
      {
        "slug": "kdm2b",
        "symbol": "KDM2B",
        "hgnc": "HGNC:13610",
        "name": "lysine demethylase 2B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm2b"
      },
      {
        "slug": "lnpk",
        "symbol": "LNPK",
        "hgnc": "HGNC:21610",
        "name": "lunapark, ER junction formation factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lnpk"
      },
      {
        "slug": "lrrc7",
        "symbol": "LRRC7",
        "hgnc": "HGNC:18531",
        "name": "leucine rich repeat containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc7"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "minpp1",
        "symbol": "MINPP1",
        "hgnc": "HGNC:7102",
        "name": "multiple inositol-polyphosphate phosphatase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/minpp1"
      },
      {
        "slug": "ndst1",
        "symbol": "NDST1",
        "hgnc": "HGNC:7680",
        "name": "N-deacetylase and N-sulfotransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndst1"
      },
      {
        "slug": "nfia",
        "symbol": "NFIA",
        "hgnc": "HGNC:7784",
        "name": "nuclear factor I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfia"
      },
      {
        "slug": "pax3",
        "symbol": "PAX3",
        "hgnc": "HGNC:8617",
        "name": "paired box 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax3"
      },
      {
        "slug": "pi4ka",
        "symbol": "PI4KA",
        "hgnc": "HGNC:8983",
        "name": "phosphatidylinositol 4-kinase alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pi4ka"
      },
      {
        "slug": "plaa",
        "symbol": "PLAA",
        "hgnc": "HGNC:9043",
        "name": "phospholipase A2 activating protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plaa"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "snx14",
        "symbol": "SNX14",
        "hgnc": "HGNC:14977",
        "name": "sorting nexin 14",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/snx14"
      },
      {
        "slug": "tmtc3",
        "symbol": "TMTC3",
        "hgnc": "HGNC:26899",
        "name": "transmembrane O-mannosyltransferase targeting cadherins 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmtc3"
      },
      {
        "slug": "trappc6b",
        "symbol": "TRAPPC6B",
        "hgnc": "HGNC:23066",
        "name": "trafficking protein particle complex subunit 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc6b"
      },
      {
        "slug": "trrap",
        "symbol": "TRRAP",
        "hgnc": "HGNC:12347",
        "name": "transformation/transcription domain associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trrap"
      },
      {
        "slug": "tsen15",
        "symbol": "TSEN15",
        "hgnc": "HGNC:16791",
        "name": "tRNA splicing endonuclease subunit 15",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsen15"
      },
      {
        "slug": "washc4",
        "symbol": "WASHC4",
        "hgnc": "HGNC:29174",
        "name": "WASH complex subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/washc4"
      },
      {
        "slug": "wsb2",
        "symbol": "WSB2",
        "hgnc": "HGNC:19222",
        "name": "WD repeat and SOCS box containing 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wsb2"
      },
      {
        "slug": "ywhaz",
        "symbol": "YWHAZ",
        "hgnc": "HGNC:12855",
        "name": "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ywhaz"
      },
      {
        "slug": "clp1",
        "symbol": "CLP1",
        "hgnc": "HGNC:16999",
        "name": "cleavage factor polyribonucleotide kinase subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clp1"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "hnrnpc",
        "symbol": "HNRNPC",
        "hgnc": "HGNC:5035",
        "name": "heterogeneous nuclear ribonucleoprotein C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpc"
      },
      {
        "slug": "myt1l",
        "symbol": "MYT1L",
        "hgnc": "HGNC:7623",
        "name": "myelin transcription factor 1 like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myt1l"
      },
      {
        "slug": "tet3",
        "symbol": "TET3",
        "hgnc": "HGNC:28313",
        "name": "tet methylcytosine dioxygenase 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet3"
      },
      {
        "slug": "tnrc6b",
        "symbol": "TNRC6B",
        "hgnc": "HGNC:29190",
        "name": "trinucleotide repeat containing adaptor 6B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnrc6b"
      },
      {
        "slug": "zfx",
        "symbol": "ZFX",
        "hgnc": "HGNC:12869",
        "name": "zinc finger protein X-linked",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfx"
      },
      {
        "slug": "ascc3",
        "symbol": "ASCC3",
        "hgnc": "HGNC:18697",
        "name": "activating signal cointegrator 1 complex subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ascc3"
      },
      {
        "slug": "dph2",
        "symbol": "DPH2",
        "hgnc": "HGNC:3004",
        "name": "diphthamide biosynthesis 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph2"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "fem1b",
        "symbol": "FEM1B",
        "hgnc": "HGNC:3649",
        "name": "fem-1 homolog B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fem1b"
      },
      {
        "slug": "kdm4b",
        "symbol": "KDM4B",
        "hgnc": "HGNC:29136",
        "name": "lysine demethylase 4B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm4b"
      },
      {
        "slug": "sec24d",
        "symbol": "SEC24D",
        "hgnc": "HGNC:10706",
        "name": "SEC24 homolog D, COPII component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24d"
      },
      {
        "slug": "sfxn4",
        "symbol": "SFXN4",
        "hgnc": "HGNC:16088",
        "name": "sideroflexin 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sfxn4"
      },
      {
        "slug": "tubb3",
        "symbol": "TUBB3",
        "hgnc": "HGNC:20772",
        "name": "tubulin beta 3 class III",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb3"
      },
      {
        "slug": "wls",
        "symbol": "WLS",
        "hgnc": "HGNC:30238",
        "name": "Wnt ligand secretion mediator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wls"
      },
      {
        "slug": "cdh2",
        "symbol": "CDH2",
        "hgnc": "HGNC:1759",
        "name": "cadherin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh2"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "hgnc": "HGNC:2188",
        "name": "collagen type XII alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col12a1"
      },
      {
        "slug": "cplx1",
        "symbol": "CPLX1",
        "hgnc": "HGNC:2309",
        "name": "complexin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cplx1"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "scn8a",
        "symbol": "SCN8A",
        "hgnc": "HGNC:10596",
        "name": "sodium voltage-gated channel alpha subunit 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn8a"
      },
      {
        "slug": "sin3a",
        "symbol": "SIN3A",
        "hgnc": "HGNC:19353",
        "name": "SIN3 transcription regulator family member A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sin3a"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "cnot3",
        "symbol": "CNOT3",
        "hgnc": "HGNC:7879",
        "name": "CCR4-NOT transcription complex subunit 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnot3"
      }
    ]
  }
}