{
  "url": "https://dantelabs.com/traits/bone-fracture",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bone-fracture",
    "id": "HP:0020110",
    "name": "Bone fracture",
    "definition": "A partial or complete breakage of the continuity of a bone.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skeletal-morphology",
        "name": "Abnormally shaped skeletal",
        "url": "https://dantelabs.com/traits/abnormal-skeletal-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "fractured-forearm-bone",
        "name": "Fractured forearm bone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/fractured-forearm-bone"
      },
      {
        "slug": "fractured-vertebra",
        "name": "Fractured vertebra",
        "genes": 1,
        "url": "https://dantelabs.com/traits/fractured-vertebra"
      },
      {
        "slug": "metatarsal-fracture",
        "name": "Metatarsal fracture",
        "genes": 1,
        "url": "https://dantelabs.com/traits/metatarsal-fracture"
      },
      {
        "slug": "fractured-hand-bones",
        "name": "Fractured hand bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/fractured-hand-bones"
      },
      {
        "slug": "long-bone-fracture",
        "name": "Long-bone fracture",
        "genes": 0,
        "url": "https://dantelabs.com/traits/long-bone-fracture"
      }
    ],
    "genes": [
      {
        "slug": "pfn1",
        "symbol": "PFN1",
        "hgnc": "HGNC:8881",
        "name": "profilin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pfn1"
      },
      {
        "slug": "uba1",
        "symbol": "UBA1",
        "hgnc": "HGNC:12469",
        "name": "ubiquitin like modifier activating enzyme 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba1"
      },
      {
        "slug": "anapc1",
        "symbol": "ANAPC1",
        "hgnc": "HGNC:19988",
        "name": "anaphase promoting complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anapc1"
      },
      {
        "slug": "fgf23",
        "symbol": "FGF23",
        "hgnc": "HGNC:3680",
        "name": "fibroblast growth factor 23",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf23"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "mogs",
        "symbol": "MOGS",
        "hgnc": "HGNC:24862",
        "name": "mannosyl-oligosaccharide glucosidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mogs"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a2"
      },
      {
        "slug": "ext1",
        "symbol": "EXT1",
        "hgnc": "HGNC:3512",
        "name": "exostosin glycosyltransferase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext1"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      }
    ]
  }
}