{
  "url": "https://dantelabs.com/traits/abnormal-transitional-b-cell-proportion",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-transitional-b-cell-proportion",
    "id": "HP:0030379",
    "name": "Abnormal transitional B cell proportion",
    "definition": "Abnormal increase or decrease of the transitional B cell subpopulation, commonly characterized as CD27-CD24hiCD38hi or CD27-IgMhiCD38hi, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.",
    "synonyms": [
      "Abnormal proportion of CD19+CD38+IgM+ cells",
      "Abnormal proportion of transitional B cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-b-cell-subset-distribution",
        "name": "Abnormal B cell subset distribution",
        "url": "https://dantelabs.com/traits/abnormal-b-cell-subset-distribution"
      }
    ],
    "narrower": [
      {
        "slug": "increased-transitional-b-cell-proportion",
        "name": "Increased transitional B cell proportion",
        "genes": 6,
        "url": "https://dantelabs.com/traits/increased-transitional-b-cell-proportion"
      }
    ],
    "genes": []
  }
}