{
  "url": "https://dantelabs.com/traits/abnormal-t-cell-activation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-t-cell-activation",
    "id": "HP:0410035",
    "name": "Abnormal T cell activation",
    "definition": "Any abnormality in the activation of T cells, i.e. the change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.",
    "synonyms": [
      "Abnormal T lymphocyte activation",
      "Abnormal T-cell activation",
      "Abnormal T-lymphocyte activation"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-t-cell-physiology",
        "name": "Impaired T cell function",
        "url": "https://dantelabs.com/traits/abnormal-t-cell-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-t-cell-activation",
        "name": "Decreased T cell activation",
        "genes": 9,
        "url": "https://dantelabs.com/traits/decreased-t-cell-activation"
      },
      {
        "slug": "abnormal-cd69-upregulation-upon-tcr-activation",
        "name": "Abnormal CD69 upregulation upon TCR activation",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-cd69-upregulation-upon-tcr-activation"
      }
    ],
    "genes": []
  }
}