{
  "url": "https://dantelabs.com/traits/abnormal-circulating-thyroid-hormone-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-thyroid-hormone-concentration",
    "id": "HP:0031508",
    "name": "Abnormal circulating thyroid hormone concentration",
    "definition": "Any deviation from the normal range of the hormones produced by the thyroid gland.",
    "synonyms": [
      "Abnormal thyroid hormone level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-thyroid-physiology",
        "name": "Abnormal thyroid function",
        "url": "https://dantelabs.com/traits/abnormality-of-thyroid-physiology"
      },
      {
        "slug": "abnormal-circulating-hormone-concentration",
        "name": "Abnormality of circulating hormone level",
        "url": "https://dantelabs.com/traits/abnormal-circulating-hormone-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-circulating-free-t4-concentration",
        "name": "Abnormal circulating free T4 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-circulating-free-t4-concentration"
      },
      {
        "slug": "elevated-circulating-rt3-t3-ratio",
        "name": "Elevated circulating rT3/T3 ratio",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-circulating-rt3-t3-ratio"
      },
      {
        "slug": "abnormal-circulating-free-t3-concentration",
        "name": "Abnormal circulating free T3 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-free-t3-concentration"
      },
      {
        "slug": "abnormal-circulating-reverse-t3-concentration",
        "name": "Abnormal circulating reverse T3 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-reverse-t3-concentration"
      },
      {
        "slug": "abnormal-circulating-t4-concentration",
        "name": "Abnormal circulating T4 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-t4-concentration"
      },
      {
        "slug": "abnormal-t3-t4-ratio",
        "name": "Abnormal T3/T4 ratio",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-t3-t4-ratio"
      }
    ],
    "genes": [
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "usp9x",
        "symbol": "USP9X",
        "hgnc": "HGNC:12632",
        "name": "ubiquitin specific peptidase 9 X-linked",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp9x"
      }
    ]
  }
}