{
  "url": "https://dantelabs.com/lt/genes/tnfrsf1a",
  "gene": {
    "slug": "tnfrsf1a",
    "symbol": "TNFRSF1A",
    "name": "TNF receptor superfamily member 1A",
    "hgnc": "HGNC:11916",
    "summary": null,
    "location": "12p13.31",
    "locusType": "gene with protein product",
    "aliases": [
      "TNF-R",
      "TNFAR",
      "TNFR60",
      "TNF-R-I",
      "CD120a",
      "TNF-R55"
    ],
    "previousSymbols": [
      "TNFR1"
    ],
    "ensemblId": "ENSG00000067182",
    "entrezId": 7132,
    "omim": [
      "191190"
    ],
    "uniprot": [
      "P19438"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 6328771,
      "end": 6342076,
      "strand": "-",
      "ensemblTranscript": "ENST00000162749.7",
      "refseqTranscript": "NM_001065.4",
      "ensemblProtein": "ENSP00000162749.2",
      "refseqProtein": "NP_001056.1",
      "exons": [
        {
          "start": 6328771,
          "end": 6329622
        },
        {
          "start": 6329778,
          "end": 6330066
        },
        {
          "start": 6330267,
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        {
          "start": 6330598,
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          "start": 6330853,
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        },
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        },
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        },
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        }
      ],
      "cds": {
        "start": 6329312,
        "end": 6341814
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
      "start": 6437923,
      "end": 6451280,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 5835424,
      "end": 6835423,
      "genes": [
        {
          "symbol": "ANO2",
          "ensemblId": "ENSG00000047617",
          "biotype": "protein_coding",
          "start": 5531869,
          "end": 5946232,
          "strand": "-",
          "slug": "ano2"
        },
        {
          "symbol": "VWF",
          "ensemblId": "ENSG00000110799",
          "biotype": "protein_coding",
          "start": 5948877,
          "end": 6124770,
          "strand": "-",
          "slug": "vwf"
        },
        {
          "symbol": "CD9",
          "ensemblId": "ENSG00000010278",
          "biotype": "protein_coding",
          "start": 6199715,
          "end": 6238271,
          "strand": "+",
          "slug": "cd9"
        },
        {
          "symbol": "PLEKHG6",
          "ensemblId": "ENSG00000008323",
          "biotype": "protein_coding",
          "start": 6310167,
          "end": 6328934,
          "strand": "+",
          "slug": "plekhg6"
        },
        {
          "symbol": "SCNN1A",
          "ensemblId": "ENSG00000111319",
          "biotype": "protein_coding",
          "start": 6345124,
          "end": 6383917,
          "strand": "-",
          "slug": "scnn1a"
        },
        {
          "symbol": "LTBR",
          "ensemblId": "ENSG00000111321",
          "biotype": "protein_coding",
          "start": 6375045,
          "end": 6391571,
          "strand": "+",
          "slug": "ltbr"
        },
        {
          "symbol": "CD27",
          "ensemblId": "ENSG00000139193",
          "biotype": "protein_coding",
          "start": 6444933,
          "end": 6451718,
          "strand": "+",
          "slug": "cd27"
        },
        {
          "symbol": "TAPBPL",
          "ensemblId": "ENSG00000139192",
          "biotype": "protein_coding",
          "start": 6451690,
          "end": 6466517,
          "strand": "+",
          "slug": "tapbpl"
        },
        {
          "symbol": "VAMP1",
          "ensemblId": "ENSG00000139190",
          "biotype": "protein_coding",
          "start": 6462237,
          "end": 6470948,
          "strand": "-",
          "slug": "vamp1"
        },
        {
          "symbol": "MRPL51",
          "ensemblId": "ENSG00000111639",
          "biotype": "protein_coding",
          "start": 6490204,
          "end": 6493856,
          "strand": "-",
          "slug": "mrpl51"
        },
        {
          "symbol": "NCAPD2",
          "ensemblId": "ENSG00000010292",
          "biotype": "protein_coding",
          "start": 6493356,
          "end": 6531970,
          "strand": "+",
          "slug": "ncapd2"
        },
        {
          "symbol": "GAPDH",
          "ensemblId": "ENSG00000111640",
          "biotype": "protein_coding",
          "start": 6534012,
          "end": 6538930,
          "strand": "+",
          "slug": "gapdh"
        },
        {
          "symbol": "IFFO1",
          "ensemblId": "ENSG00000010295",
          "biotype": "protein_coding",
          "start": 6538961,
          "end": 6556102,
          "strand": "-",
          "slug": "iffo1"
        },
        {
          "symbol": "NOP2",
          "ensemblId": "ENSG00000111641",
          "biotype": "protein_coding",
          "start": 6556863,
          "end": 6568691,
          "strand": "-",
          "slug": "nop2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285238",
          "biotype": "protein_coding",
          "start": 6556886,
          "end": 6607367,
          "strand": "-"
        },
        {
          "symbol": "CHD4",
          "ensemblId": "ENSG00000111642",
          "biotype": "protein_coding",
          "start": 6570081,
          "end": 6614982,
          "strand": "-",
          "slug": "chd4"
        },
        {
          "symbol": "LPAR5",
          "ensemblId": "ENSG00000184574",
          "biotype": "protein_coding",
          "start": 6618835,
          "end": 6636444,
          "strand": "-",
          "slug": "lpar5"
        },
        {
          "symbol": "ACRBP",
          "ensemblId": "ENSG00000111644",
          "biotype": "protein_coding",
          "start": 6638075,
          "end": 6647441,
          "strand": "-",
          "slug": "acrbp"
        },
        {
          "symbol": "ING4",
          "ensemblId": "ENSG00000111653",
          "biotype": "protein_coding",
          "start": 6650282,
          "end": 6663180,
          "strand": "-",
          "slug": "ing4"
        },
        {
          "symbol": "ZNF384",
          "ensemblId": "ENSG00000126746",
          "biotype": "protein_coding",
          "start": 6665037,
          "end": 6689572,
          "strand": "-",
          "slug": "znf384"
        },
        {
          "symbol": "PIANP",
          "ensemblId": "ENSG00000139200",
          "biotype": "protein_coding",
          "start": 6693791,
          "end": 6700859,
          "strand": "-",
          "slug": "pianp"
        },
        {
          "symbol": "COPS7A",
          "ensemblId": "ENSG00000111652",
          "biotype": "protein_coding",
          "start": 6724014,
          "end": 6732462,
          "strand": "+",
          "slug": "cops7a"
        },
        {
          "symbol": "MLF2",
          "ensemblId": "ENSG00000089693",
          "biotype": "protein_coding",
          "start": 6747986,
          "end": 6768932,
          "strand": "-",
          "slug": "mlf2"
        },
        {
          "symbol": "PTMS",
          "ensemblId": "ENSG00000159335",
          "biotype": "protein_coding",
          "start": 6765516,
          "end": 6770952,
          "strand": "+",
          "slug": "ptms"
        },
        {
          "symbol": "LAG3",
          "ensemblId": "ENSG00000089692",
          "biotype": "protein_coding",
          "start": 6772360,
          "end": 6778455,
          "strand": "+",
          "slug": "lag3"
        },
        {
          "symbol": "CD4",
          "ensemblId": "ENSG00000010610",
          "biotype": "protein_coding",
          "start": 6786858,
          "end": 6820807,
          "strand": "+",
          "slug": "cd4"
        },
        {
          "symbol": "GPR162",
          "ensemblId": "ENSG00000250510",
          "biotype": "protein_coding",
          "start": 6821624,
          "end": 6829972,
          "strand": "+",
          "slug": "gpr162"
        },
        {
          "symbol": "P3H3",
          "ensemblId": "ENSG00000110811",
          "biotype": "protein_coding",
          "start": 6828220,
          "end": 6839867,
          "strand": "+",
          "slug": "p3h3"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-periodic-fever-syndromes",
        "name": "Nasledni periodiniai karščiavimo sindromai",
        "diseases": [
          {
            "mondoId": "MONDO:0007727",
            "name": "Su TNF receptoriumi susijęs periodinis sindromas (TRAPS)",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "Jį sukelia TNFRSF1A pokyčiai; jis lemia ilgai trunkančius karščiavimo epizodus su pilvo skausmu, raumenų skausmu, bėrimu ir akių patinimu.",
            "management": "Priešuždegiminis gydymas ir interleukino-1 blokatoriai sumažina priepuolių skaičių ir ilgalaikę inkstų amiloidozės riziką.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "G2P",
                "Illumina",
                "Labcorp Genetics (formerly Invitae)",
                "Laboratory for Molecular Medicine",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/hereditary-periodic-fever-syndromes"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "aa-amyloidosis",
        "name": "AA amyloidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aa-amyloidosis"
      },
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-myocardium-morphology",
        "name": "Abnormal myocardium morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-myocardium-morphology"
      },
      {
        "slug": "abnormal-sacroiliac-joint-morphology",
        "name": "Abnormal sacroiliac joint morphology",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-sacroiliac-joint-morphology"
      },
      {
        "slug": "abnormality-of-the-knee",
        "name": "Abnormality of the knee",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-knee"
      },
      {
        "slug": "arthritis",
        "name": "Arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arthritis"
      },
      {
        "slug": "cellulitis",
        "name": "Bacterial infection of skin",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cellulitis"
      },
      {
        "slug": "atypical-behavior",
        "name": "Behavioral abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atypical-behavior"
      },
      {
        "slug": "bone-pain",
        "name": "Bone pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/bone-pain"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "chondrocalcinosis",
        "name": "Calcium deposits in joints",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/chondrocalcinosis"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "chronic-constipation",
        "name": "Chronic constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chronic-constipation"
      },
      {
        "slug": "chronic-diarrhea",
        "name": "Chronic diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chronic-diarrhea"
      },
      {
        "slug": "conjunctival-hyperemia",
        "name": "Conjunctival hyperemia",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/conjunctival-hyperemia"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "cranial-nerve-paralysis",
        "name": "Cranial nerve paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cranial-nerve-paralysis"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "vertigo",
        "name": "Dizziness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vertigo"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "recurrent-fever",
        "name": "Episodic fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-fever"
      },
      {
        "slug": "erysipelas",
        "name": "Erysipelas",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/erysipelas"
      },
      {
        "slug": "macule",
        "name": "Flat, discolored area of skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/macule"
      },
      {
        "slug": "gastrointestinal-hemorrhage",
        "name": "Gastrointestinal bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/gastrointestinal-hemorrhage"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hepatic-amyloidosis",
        "name": "Hepatic amyloidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/hepatic-amyloidosis"
      },
      {
        "slug": "elevated-erythrocyte-sedimentation-rate",
        "name": "High ESR",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-erythrocyte-sedimentation-rate"
      },
      {
        "slug": "hypermelanotic-macule",
        "name": "Hyperpigmented skin patches",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypermelanotic-macule"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "vasculitis",
        "name": "Inflammation of blood vessel",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vasculitis"
      },
      {
        "slug": "orchitis",
        "name": "Inflammation of testicles",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/orchitis"
      },
      {
        "slug": "fasciitis",
        "name": "Inflammation of the fascia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fasciitis"
      },
      {
        "slug": "pleuritis",
        "name": "Inflammation of tissues lining lungs and chest",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pleuritis"
      },
      {
        "slug": "intestinal-obstruction",
        "name": "Intestinal obstruction",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intestinal-obstruction"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "joint-swelling",
        "name": "Joint swelling",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/joint-swelling"
      },
      {
        "slug": "knee-joint-hypermobility",
        "name": "Knee joint over-flexibility",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/knee-joint-hypermobility"
      },
      {
        "slug": "maculopapular-exanthema",
        "name": "Maculopapular exanthema",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/maculopapular-exanthema"
      },
      {
        "slug": "migraine",
        "name": "Migraine",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/migraine"
      },
      {
        "slug": "myalgia",
        "name": "Muscle ache",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/myalgia"
      },
      {
        "slug": "myositis",
        "name": "Muscle inflammation",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myositis"
      },
      {
        "slug": "muscle-stiffness",
        "name": "Muscle stiffness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/muscle-stiffness"
      },
      {
        "slug": "oligoarthritis",
        "name": "Oligoarthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligoarthritis"
      },
      {
        "slug": "periorbital-edema",
        "name": "Periorbital edema",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/periorbital-edema"
      },
      {
        "slug": "peritonitis",
        "name": "Peritonitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peritonitis"
      },
      {
        "slug": "conjunctivitis",
        "name": "Pink eye",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/conjunctivitis"
      },
      {
        "slug": "paresthesia",
        "name": "Pins and needles feeling",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/paresthesia"
      },
      {
        "slug": "polyarticular-arthritis",
        "name": "Polyarticular arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/polyarticular-arthritis"
      },
      {
        "slug": "recurrent-pharyngitis",
        "name": "Recurrent sore throat",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-pharyngitis"
      },
      {
        "slug": "erythema",
        "name": "Redness of skin or mucous membrane",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/erythema"
      },
      {
        "slug": "skin-rash",
        "name": "Skin rash",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/skin-rash"
      },
      {
        "slug": "pericarditis",
        "name": "Swelling or irritation of membrane around heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pericarditis"
      },
      {
        "slug": "lymphadenopathy",
        "name": "Swollen lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/lymphadenopathy"
      },
      {
        "slug": "cervical-lymphadenopathy",
        "name": "Swollen lymph nodes in the neck",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cervical-lymphadenopathy"
      },
      {
        "slug": "uveitis",
        "name": "Uveitis",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/uveitis"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vomiting"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}