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15809348, "strand": "-", "slug": "uqcrhl" }, { "symbol": "SPEN", "ensemblId": "ENSG00000065526", "biotype": "protein_coding", "start": 15836095, "end": 15940456, "strand": "+", "slug": "spen" }, { "symbol": "ZBTB17", "ensemblId": "ENSG00000116809", "biotype": "protein_coding", "start": 15940148, "end": 15976132, "strand": "-", "slug": "zbtb17" }, { "symbol": "SRARP", "ensemblId": "ENSG00000183888", "biotype": "protein_coding", "start": 16004229, "end": 16009382, "strand": "+", "slug": "srarp" }, { "symbol": "HSPB7", "ensemblId": "ENSG00000173641", "biotype": "protein_coding", "start": 16014018, "end": 16020597, "strand": "-", "slug": "hspb7" }, { "symbol": "CLCNKA", "ensemblId": "ENSG00000186510", "biotype": "protein_coding", "start": 16018146, "end": 16034109, "strand": "+", "slug": "clcnka" }, { "symbol": "CLCNKB", "ensemblId": "ENSG00000184908", "biotype": "protein_coding", "start": 16040252, "end": 16057367, "strand": "+", "slug": "clcnkb" }, { "symbol": "FAM131C", "ensemblId": "ENSG00000185519", "biotype": "protein_coding", "start": 16057769, "end": 16073664, "strand": "-", "slug": "fam131c" }, { "symbol": "EPHA2", "ensemblId": "ENSG00000142627", "biotype": "protein_coding", "start": 16124337, "end": 16156141, "strand": "-", "slug": "epha2" }, { "symbol": "ARHGEF19", "ensemblId": "ENSG00000142632", "biotype": "protein_coding", "start": 16197854, "end": 16212893, "strand": "-", "slug": "arhgef19" } ], "truncated": false }, "reports": [ { "slug": "dilated-cardiomyopathy", "name": "Dilatuota kardiomiopatija", "diseases": [ { "mondoId": "MONDO:0005021", "name": "Dilatuota kardiomiopatija", "genes": 50, "inheritance": null, "description": "Kairiojo skilvelio išsiplėtimas ir susilpnėjimas, kurio nepaaiškina vainikinių arterijų ar vožtuvų liga; paveldimos formos susijusios su TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN ir daugeliu kitų genų, į jas įeina Barth sindromas ir Emery-Dreifuss raumenų distrofijos.", "management": "Žinojimas apie genetinę priežastį padeda anksčiau pradėti širdies stebėseną ir šeimos narių tikrinimą, o turint genus su dideliu aritmijos rizika, pavyzdžiui, LMNA, FLNC ir RBM20, tai padeda priimti sprendimus dėl ritmo stebėsenos ir implantuojamų defibriliatorių.", "evidence": { "gencc": [], "clingen": "Moderate", "acmgSf": false, "inheritance": [ "autosomal-recessive" ] }, "sameAsReport": true, "broad": false } ], "url": "https://dantelabs.com/lt/conditions/dilated-cardiomyopathy" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [], "related": [ { "slug": "abcc9", "symbol": "ABCC9", "name": "ATP binding cassette subfamily C member 9", "shared": 1, "url": "https://dantelabs.com/lt/genes/abcc9" }, { "slug": "actc1", "symbol": "ACTC1", "name": "actin alpha cardiac muscle 1", "shared": 1, "url": "https://dantelabs.com/lt/genes/actc1" }, { "slug": "bag3", "symbol": "BAG3", "name": "BAG cochaperone 3", "shared": 1, "url": "https://dantelabs.com/lt/genes/bag3" }, { "slug": "bag5", "symbol": "BAG5", "name": "BAG cochaperone 5", "shared": 1, "url": "https://dantelabs.com/lt/genes/bag5" }, { "slug": "des", "symbol": "DES", "name": "desmin", "shared": 1, "url": "https://dantelabs.com/lt/genes/des" }, { "slug": "dmd", "symbol": "DMD", "name": "dystrophin", "shared": 1, "url": "https://dantelabs.com/lt/genes/dmd" }, { "slug": "dolk", "symbol": "DOLK", "name": "dolichol kinase", "shared": 1, "url": "https://dantelabs.com/lt/genes/dolk" }, { "slug": "emd", "symbol": "EMD", "name": "emerin", "shared": 1, "url": "https://dantelabs.com/lt/genes/emd" }, { "slug": "fhl1", "symbol": "FHL1", "name": "four and a half LIM domains 1", "shared": 1, "url": "https://dantelabs.com/lt/genes/fhl1" }, { "slug": "fktn", "symbol": "FKTN", "name": "fukutin", "shared": 1, "url": "https://dantelabs.com/lt/genes/fktn" }, { "slug": "flii", "symbol": "FLII", "name": "FLII actin remodeling protein", "shared": 1, "url": "https://dantelabs.com/lt/genes/flii" }, { "slug": "flnc", "symbol": "FLNC", "name": "filamin C", "shared": 1, "url": "https://dantelabs.com/lt/genes/flnc" } ], "sources": { "bundleId": "2026.10.17-8666dff2", "panel": "2026-10-17", "acmgSf": "SF v3.2" }, "locusKind": "proteinCoding" }, "variants": { "total": 0, "url": null, "items": [] } }