{
  "url": "https://dantelabs.com/lt/genes/msh3",
  "gene": {
    "slug": "msh3",
    "symbol": "MSH3",
    "name": "mutS homolog 3",
    "hgnc": "HGNC:7326",
    "summary": null,
    "location": "5q14.1",
    "locusType": "gene with protein product",
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      "MRP1"
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    "previousSymbols": [],
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    "entrezId": 4437,
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    "uniprot": [
      "P20585"
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      "strand": "+",
      "ensemblTranscript": "ENST00000265081.7",
      "refseqTranscript": "NM_002439.5",
      "ensemblProtein": "ENSP00000265081.6",
      "refseqProtein": "NP_002430.3",
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "5",
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      "strand": "+"
    },
    "neighbourhood": {
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        {
          "symbol": "SPZ1",
          "ensemblId": "ENSG00000164299",
          "biotype": "protein_coding",
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          "strand": "+",
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        },
        {
          "symbol": "ZFYVE16",
          "ensemblId": "ENSG00000039319",
          "biotype": "protein_coding",
          "start": 80407149,
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        {
          "symbol": "FAM151B",
          "ensemblId": "ENSG00000152380",
          "biotype": "protein_coding",
          "start": 80487954,
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          "strand": "+",
          "slug": "fam151b"
        },
        {
          "symbol": "ANKRD34B",
          "ensemblId": "ENSG00000189127",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
          "symbol": "DHFR",
          "ensemblId": "ENSG00000228716",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "dhfr"
        },
        {
          "symbol": "RASGRF2",
          "ensemblId": "ENSG00000113319",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "CKMT2",
          "ensemblId": "ENSG00000131730",
          "biotype": "protein_coding",
          "start": 81232673,
          "end": 81266400,
          "strand": "+",
          "slug": "ckmt2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "colorectal-cancer-polyposis",
        "name": "Kolorektālinis vėžys ir polipozė",
        "diseases": [
          {
            "mondoId": "MONDO:0021057",
            "name": "Šeiminė adenomatozinė polipozė (klasikinė arba atenuota)",
            "genes": 6,
            "inheritance": "autosomal-dominant",
            "description": "Šimtai ar tūkstančiai storosios žarnos adenomų, be gydymo – beveik neabejotina storosios žarnos vėžio rizika; apima su APC susijusią FAP ir su MUTYH, NTHL1 bei MSH3 susijusias polipozes.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/colorectal-cancer-polyposis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "adenomatous-colonic-polyposis",
        "name": "Adenomatous colonic polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/adenomatous-colonic-polyposis"
      },
      {
        "slug": "astrocytoma",
        "name": "Astrocytoma",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/astrocytoma"
      },
      {
        "slug": "breast-intraductal-papilloma",
        "name": "Breast intraductal papilloma",
        "systems": [
          "abnormality-of-the-breast",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/breast-intraductal-papilloma"
      },
      {
        "slug": "colon-cancer",
        "name": "Colon cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/colon-cancer"
      },
      {
        "slug": "colorectal-polyposis",
        "name": "Colorectal polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/colorectal-polyposis"
      },
      {
        "slug": "renal-cyst",
        "name": "Cystic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-cyst"
      },
      {
        "slug": "duodenal-polyposis",
        "name": "Duodenal polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/duodenal-polyposis"
      },
      {
        "slug": "endometrial-carcinoma",
        "name": "Endometrial carcinoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/endometrial-carcinoma"
      },
      {
        "slug": "gastric-adenocarcinoma",
        "name": "Gastric adenocarcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastric-adenocarcinoma"
      },
      {
        "slug": "juvenile-gastrointestinal-polyposis",
        "name": "Juvenile gastrointestinal polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/juvenile-gastrointestinal-polyposis"
      },
      {
        "slug": "multiple-gastric-polyps",
        "name": "Multiple gastric polyps",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/multiple-gastric-polyps"
      },
      {
        "slug": "ovarian-cyst",
        "name": "Ovarian cyst",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ovarian-cyst"
      },
      {
        "slug": "ovarian-dermoid-cyst",
        "name": "Ovarian dermoid cyst",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ovarian-dermoid-cyst"
      },
      {
        "slug": "papilloma",
        "name": "Papilloma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/papilloma"
      },
      {
        "slug": "neoplasm-of-the-rectum",
        "name": "Rectal tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-rectum"
      },
      {
        "slug": "neoplasm-of-the-skin",
        "name": "Skin cancer",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-skin"
      },
      {
        "slug": "stomach-cancer",
        "name": "Stomach cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stomach-cancer"
      },
      {
        "slug": "thyroid-adenoma",
        "name": "Thyroid adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thyroid-adenoma"
      },
      {
        "slug": "uterine-leiomyoma",
        "name": "Uterine leiomyoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/uterine-leiomyoma"
      }
    ],
    "related": [
      {
        "slug": "apc",
        "symbol": "APC",
        "name": "APC regulator of Wnt signaling pathway",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/apc"
      },
      {
        "slug": "mutyh",
        "symbol": "MUTYH",
        "name": "mutY DNA glycosylase",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/mutyh"
      },
      {
        "slug": "nthl1",
        "symbol": "NTHL1",
        "name": "nth like DNA glycosylase 1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/nthl1"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/pold1"
      },
      {
        "slug": "pole",
        "symbol": "POLE",
        "name": "DNA polymerase epsilon, catalytic subunit",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/pole"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}