{
  "url": "https://dantelabs.com/lt/genes/lpar6",
  "gene": {
    "slug": "lpar6",
    "symbol": "LPAR6",
    "name": "lysophosphatidic acid receptor 6",
    "hgnc": "HGNC:15520",
    "summary": null,
    "location": "13q14.2",
    "locusType": "gene with protein product",
    "aliases": [
      "P2Y5"
    ],
    "previousSymbols": [
      "P2RY5"
    ],
    "ensemblId": "ENSG00000139679",
    "entrezId": 10161,
    "omim": [
      "609239"
    ],
    "uniprot": [
      "P43657"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 48411138,
      "end": 48413113,
      "strand": "-",
      "ensemblTranscript": "ENST00000620633.5",
      "refseqTranscript": "NM_001162498.3",
      "ensemblProtein": "ENSP00000482660.1",
      "refseqProtein": "NP_001155970.1",
      "exons": [
        {
          "start": 48411138,
          "end": 48413113
        }
      ],
      "cds": {
        "start": 48411389,
        "end": 48412423
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 48963707,
      "end": 49018840,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 47912126,
      "end": 48912125,
      "genes": [
        {
          "symbol": "SUCLA2",
          "ensemblId": "ENSG00000136143",
          "biotype": "protein_coding",
          "start": 47745736,
          "end": 48037968,
          "strand": "-",
          "slug": "sucla2"
        },
        {
          "symbol": "MED4",
          "ensemblId": "ENSG00000136146",
          "biotype": "protein_coding",
          "start": 48001823,
          "end": 48095150,
          "strand": "-",
          "slug": "med4"
        },
        {
          "symbol": "NUDT15",
          "ensemblId": "ENSG00000136159",
          "biotype": "protein_coding",
          "start": 48037514,
          "end": 48054196,
          "strand": "+",
          "slug": "nudt15"
        },
        {
          "symbol": "ITM2B",
          "ensemblId": "ENSG00000136156",
          "biotype": "protein_coding",
          "start": 48232612,
          "end": 48270357,
          "strand": "+",
          "slug": "itm2b"
        },
        {
          "symbol": "RB1",
          "ensemblId": "ENSG00000139687",
          "biotype": "protein_coding",
          "start": 48303710,
          "end": 48599436,
          "strand": "+",
          "slug": "rb1"
        },
        {
          "symbol": "RCBTB2",
          "ensemblId": "ENSG00000136161",
          "biotype": "protein_coding",
          "start": 48488858,
          "end": 48536006,
          "strand": "-",
          "slug": "rcbtb2"
        },
        {
          "symbol": "CYSLTR2",
          "ensemblId": "ENSG00000152207",
          "biotype": "protein_coding",
          "start": 48653709,
          "end": 48711227,
          "strand": "+",
          "slug": "cysltr2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-hypotrichosis-and-hair-shaft-disorders",
        "name": "Paveldėta retas plaukuotumas, vilnoti plaukai ir monilethrix",
        "diseases": [
          {
            "mondoId": "MONDO:0800312",
            "name": "Autosominis recesyvinis vilnotas plaukuotumas 1",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Stipriai garbanoti, dažnai reti plaukai, susiję su LIPH/LPAR6 signaliniu keliu.",
            "management": null,
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0003037",
            "name": "Paveldimas retas plaukuotumas",
            "genes": 11,
            "inheritance": null,
            "description": "Reti arba nebūvantys galvos ir kūno plaukai nuo vaikystės, įskaitant su LIPH ir LPAR6 susijusias formas.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/hereditary-hypotrichosis-and-hair-shaft-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-hair-texture",
        "name": "Abnormality of hair texture",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-hair-texture"
      },
      {
        "slug": "abnormal-pupil-morphology",
        "name": "Abnormality of the pupil",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-pupil-morphology"
      },
      {
        "slug": "woolly-hair",
        "name": "Afro-textured hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/woolly-hair"
      },
      {
        "slug": "brittle-hair",
        "name": "Brittle hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/brittle-hair"
      },
      {
        "slug": "cataract",
        "name": "Clouding of the lens of the eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cataract"
      },
      {
        "slug": "coarse-hair",
        "name": "Coarse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/coarse-hair"
      },
      {
        "slug": "comedo",
        "name": "Comedo",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/comedo"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "dry-hair",
        "name": "Dry hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dry-hair"
      },
      {
        "slug": "fair-hair",
        "name": "Fair hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/fair-hair"
      },
      {
        "slug": "fine-hair",
        "name": "Fine hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/fine-hair"
      },
      {
        "slug": "ridged-nail",
        "name": "Grooved nails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ridged-nail"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "sparse-axillary-hair",
        "name": "Limited armpit hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sparse-axillary-hair"
      },
      {
        "slug": "sparse-lateral-eyebrow",
        "name": "Limited hair on end of eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sparse-lateral-eyebrow"
      },
      {
        "slug": "hypopigmentation-of-hair",
        "name": "Loss of hair color",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypopigmentation-of-hair"
      },
      {
        "slug": "nail-pits",
        "name": "Nail pits",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nail-pits"
      },
      {
        "slug": "abnormal-retinal-morphology",
        "name": "Retina issue",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-retinal-morphology"
      },
      {
        "slug": "slow-growing-hair",
        "name": "Slow-growing hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/slow-growing-hair"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      },
      {
        "slug": "sparse-eyelashes",
        "name": "Sparse eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-eyelashes"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "sparse-scalp-hair",
        "name": "Sparse scalp hair",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-scalp-hair"
      }
    ],
    "related": [
      {
        "slug": "apcdd1",
        "symbol": "APCDD1",
        "name": "APC down-regulated 1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/apcdd1"
      },
      {
        "slug": "c3orf52",
        "symbol": "C3orf52",
        "name": "chromosome 3 open reading frame 52",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/c3orf52"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "name": "cadherin 3",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cdh3"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "name": "corneodesmosin",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cdsn"
      },
      {
        "slug": "dsg4",
        "symbol": "DSG4",
        "name": "desmoglein 4",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/dsg4"
      },
      {
        "slug": "hr",
        "symbol": "HR",
        "name": "HR lysine demethylase and nuclear receptor corepressor",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/hr"
      },
      {
        "slug": "liph",
        "symbol": "LIPH",
        "name": "lipase H",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/liph"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "name": "lanosterol synthase",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/lss"
      },
      {
        "slug": "rpl21",
        "symbol": "RPL21",
        "name": "ribosomal protein L21",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/rpl21"
      },
      {
        "slug": "snrpe",
        "symbol": "SNRPE",
        "name": "small nuclear ribonucleoprotein polypeptide E",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/snrpe"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}