{
  "url": "https://dantelabs.com/lt/genes/klf1",
  "gene": {
    "slug": "klf1",
    "symbol": "KLF1",
    "name": "KLF transcription factor 1",
    "hgnc": "HGNC:6345",
    "summary": null,
    "location": "19p13.13",
    "locusType": "gene with protein product",
    "aliases": [
      "EKLF"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000105610",
    "entrezId": 10661,
    "omim": [
      "600599"
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    "uniprot": [
      "Q13351"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "19",
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      "end": 12887201,
      "strand": "-",
      "ensemblTranscript": "ENST00000264834.6",
      "refseqTranscript": "NM_006563.5",
      "ensemblProtein": "ENSP00000264834.3",
      "refseqProtein": "NP_006554.1",
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        {
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          "end": 12885060
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        {
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      ],
      "cds": {
        "start": 12884885,
        "end": 12887140
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "19",
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      "end": 12997995,
      "strand": "-"
    },
    "neighbourhood": {
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        {
          "symbol": "ZNF799",
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        {
          "symbol": "",
          "ensemblId": "ENSG00000268870",
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        },
        {
          "symbol": "ZNF443",
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        {
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          "ensemblId": "ENSG00000269755",
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        {
          "symbol": "ZNF709",
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        {
          "symbol": "",
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        {
          "symbol": "ZNF564",
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        {
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        {
          "symbol": "ZNF490",
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        {
          "symbol": "ZNF791",
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        {
          "symbol": "MAN2B1",
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        {
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        {
          "symbol": "",
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        {
          "symbol": "WDR83",
          "ensemblId": "ENSG00000123154",
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        {
          "symbol": "WDR83OS",
          "ensemblId": "ENSG00000105583",
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        {
          "symbol": "",
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        {
          "symbol": "DHPS",
          "ensemblId": "ENSG00000095059",
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        {
          "symbol": "FBXW9",
          "ensemblId": "ENSG00000132004",
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        {
          "symbol": "GNG14",
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          "biotype": "protein_coding",
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        {
          "symbol": "TNPO2",
          "ensemblId": "ENSG00000105576",
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        {
          "symbol": "TRIR",
          "ensemblId": "ENSG00000123144",
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          "slug": "trir"
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        {
          "symbol": "GET3",
          "ensemblId": "ENSG00000198356",
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          "slug": "get3"
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        {
          "symbol": "BEST2",
          "ensemblId": "ENSG00000039987",
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        {
          "symbol": "HOOK2",
          "ensemblId": "ENSG00000095066",
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        {
          "symbol": "JUNB",
          "ensemblId": "ENSG00000171223",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "PRDX2",
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          "biotype": "protein_coding",
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        {
          "symbol": "THSD8",
          "ensemblId": "ENSG00000284491",
          "biotype": "protein_coding",
          "start": 12802031,
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          "slug": "thsd8"
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        {
          "symbol": "RNASEH2A",
          "ensemblId": "ENSG00000104889",
          "biotype": "protein_coding",
          "start": 12806505,
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          "slug": "rnaseh2a"
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        {
          "symbol": "RTBDN",
          "ensemblId": "ENSG00000132026",
          "biotype": "protein_coding",
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        {
          "symbol": "MAST1",
          "ensemblId": "ENSG00000105613",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "mast1"
        },
        {
          "symbol": "DNASE2",
          "ensemblId": "ENSG00000105612",
          "biotype": "protein_coding",
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          "slug": "dnase2"
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        {
          "symbol": "GCDH",
          "ensemblId": "ENSG00000105607",
          "biotype": "protein_coding",
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        {
          "symbol": "SYCE2",
          "ensemblId": "ENSG00000161860",
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        {
          "symbol": "FARSA",
          "ensemblId": "ENSG00000179115",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "CALR",
          "ensemblId": "ENSG00000179218",
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        {
          "symbol": "RAD23A",
          "ensemblId": "ENSG00000179262",
          "biotype": "protein_coding",
          "start": 12945716,
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          "slug": "rad23a"
        },
        {
          "symbol": "GADD45GIP1",
          "ensemblId": "ENSG00000179271",
          "biotype": "protein_coding",
          "start": 12950701,
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          "strand": "-",
          "slug": "gadd45gip1"
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        {
          "symbol": "DAND5",
          "ensemblId": "ENSG00000179284",
          "biotype": "protein_coding",
          "start": 12965159,
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          "strand": "+",
          "slug": "dand5"
        },
        {
          "symbol": "NFIX",
          "ensemblId": "ENSG00000008441",
          "biotype": "protein_coding",
          "start": 12995401,
          "end": 13098796,
          "strand": "+",
          "slug": "nfix"
        },
        {
          "symbol": "LYL1",
          "ensemblId": "ENSG00000104903",
          "biotype": "protein_coding",
          "start": 13099028,
          "end": 13103188,
          "strand": "-",
          "slug": "lyl1"
        },
        {
          "symbol": "TRMT1",
          "ensemblId": "ENSG00000104907",
          "biotype": "protein_coding",
          "start": 13104899,
          "end": 13117567,
          "strand": "-",
          "slug": "trmt1"
        },
        {
          "symbol": "NACC1",
          "ensemblId": "ENSG00000160877",
          "biotype": "protein_coding",
          "start": 13116468,
          "end": 13141147,
          "strand": "+",
          "slug": "nacc1"
        },
        {
          "symbol": "STX10",
          "ensemblId": "ENSG00000104915",
          "biotype": "protein_coding",
          "start": 13144058,
          "end": 13150383,
          "strand": "-",
          "slug": "stx10"
        },
        {
          "symbol": "IER2",
          "ensemblId": "ENSG00000160888",
          "biotype": "protein_coding",
          "start": 13150403,
          "end": 13156981,
          "strand": "+",
          "slug": "ier2"
        },
        {
          "symbol": "CACNA1A",
          "ensemblId": "ENSG00000141837",
          "biotype": "protein_coding",
          "start": 13206442,
          "end": 13624489,
          "strand": "-",
          "slug": "cacna1a"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-dyserythropoietic-anaemias",
        "name": "Įgimtos diseritropoetinės anemijos",
        "diseases": [
          {
            "mondoId": "MONDO:0019403",
            "name": "Įgimta diseritropoetinė anemija",
            "genes": 4,
            "inheritance": null,
            "description": "Ligų grupė (I–IV tipai ir susiję variantai), kurią sukelia tokių genų kaip CDAN1, CDIN1, SEC23B, KIF23, KLF1 ir GATA1 pokyčiai. Dažniausiai paveldima autosominiu recesyviniu būdu, kai kurios formos – dominantiniu.",
            "management": "Diagnozė padeda parinkti geležies pertekliaus stebėseną ir gydymą, nes jis gali išsivystyti net ir be perpylimų; I tipo atveju gali padėti interferonas alfa.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/congenital-dyserythropoietic-anaemias"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-bone-structure",
        "name": "Abnormal bone structure",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-bone-structure"
      },
      {
        "slug": "asplenia",
        "name": "Absent spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asplenia"
      },
      {
        "slug": "acute-pancreatitis",
        "name": "Acute pancreatic inflammation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/acute-pancreatitis"
      },
      {
        "slug": "anemia-of-inadequate-production",
        "name": "Anemia of inadequate production",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/anemia-of-inadequate-production"
      },
      {
        "slug": "anisopoikilocytosis",
        "name": "Anisopoikilocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anisopoikilocytosis"
      },
      {
        "slug": "leukemia",
        "name": "Blood cancer",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/leukemia"
      },
      {
        "slug": "circulating-nucleated-red-blood-cells",
        "name": "Circulating nucleated red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/circulating-nucleated-red-blood-cells"
      },
      {
        "slug": "conjugated-hyperbilirubinemia",
        "name": "Conjugated hyperbilirubinemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/conjugated-hyperbilirubinemia"
      },
      {
        "slug": "decreased-circulating-haptoglobin-concentration",
        "name": "Decreased circulating haptoglobin concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-haptoglobin-concentration"
      },
      {
        "slug": "decreased-hemoglobin-concentration",
        "name": "Decreased hemoglobin concentration",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-hemoglobin-concentration"
      },
      {
        "slug": "decreased-mean-corpuscular-hemoglobin-concentration",
        "name": "Decreased mean corpuscular hemoglobin concentration",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-mean-corpuscular-hemoglobin-concentration"
      },
      {
        "slug": "decreased-mean-corpuscular-volume",
        "name": "Decreased mean corpuscular volume",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-mean-corpuscular-volume"
      },
      {
        "slug": "elevated-circulating-alanine-aminotransferase-concentration",
        "name": "Elevated circulating alanine aminotransferase concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-alanine-aminotransferase-concentration"
      },
      {
        "slug": "elevated-circulating-aspartate-aminotransferase-concentration",
        "name": "Elevated circulating aspartate aminotransferase concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-aspartate-aminotransferase-concentration"
      },
      {
        "slug": "elevated-circulating-erythropoietin-concentration",
        "name": "Elevated circulating erythropoietin concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-erythropoietin-concentration"
      },
      {
        "slug": "hypertrophic-cardiomyopathy",
        "name": "Enlarged and thickened heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypertrophic-cardiomyopathy"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "hepatosplenomegaly",
        "name": "Enlarged liver and spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hepatosplenomegaly"
      },
      {
        "slug": "erythroid-dysplasia",
        "name": "Erythroid dysplasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/erythroid-dysplasia"
      },
      {
        "slug": "erythroid-hyperplasia",
        "name": "Erythroid hyperplasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/erythroid-hyperplasia"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "frontal-bossing",
        "name": "Frontal bossing",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/frontal-bossing"
      },
      {
        "slug": "cholelithiasis",
        "name": "Gallstones",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cholelithiasis"
      },
      {
        "slug": "hbs-hemoglobin",
        "name": "HbS hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hbs-hemoglobin"
      },
      {
        "slug": "hemoglobin-barts",
        "name": "Hemoglobin Barts",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hemoglobin-barts"
      },
      {
        "slug": "hemolytic-anemia",
        "name": "Hemolytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hemolytic-anemia"
      },
      {
        "slug": "increased-total-bilirubin",
        "name": "High bili total",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-total-bilirubin"
      },
      {
        "slug": "hyperbilirubinemia",
        "name": "High blood bilirubin levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperbilirubinemia"
      },
      {
        "slug": "hydrops-fetalis",
        "name": "Hydrops fetalis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hydrops-fetalis"
      },
      {
        "slug": "hypersplenism",
        "name": "Hypersplenism",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypersplenism"
      },
      {
        "slug": "hypochromia",
        "name": "Hypochromia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypochromia"
      },
      {
        "slug": "hypochromic-microcytic-anemia",
        "name": "Hypochromic microcytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypochromic-microcytic-anemia"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "increased-circulating-lactate-dehydrogenase-concentration",
        "name": "Increased circulating lactate dehydrogenase concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-lactate-dehydrogenase-concentration"
      },
      {
        "slug": "reticulocytosis",
        "name": "Increased immature red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reticulocytosis"
      },
      {
        "slug": "increased-rbc-distribution-width",
        "name": "Increased RBC distribution width",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-rbc-distribution-width"
      },
      {
        "slug": "increased-red-cell-sickling-tendency",
        "name": "Increased red cell sickling tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-red-cell-sickling-tendency"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "pulmonary-infiltrates",
        "name": "Lung infiltrates",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-infiltrates"
      },
      {
        "slug": "malaise",
        "name": "Malaise",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/malaise"
      },
      {
        "slug": "retinopathy",
        "name": "Noninflammatory retina disease",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinopathy"
      },
      {
        "slug": "pallor",
        "name": "Paleness",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pallor"
      },
      {
        "slug": "persistence-of-hemoglobin-f",
        "name": "Persistence of hemoglobin F",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/persistence-of-hemoglobin-f"
      },
      {
        "slug": "poikilocytosis",
        "name": "Poikilocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/poikilocytosis"
      },
      {
        "slug": "polychromasia",
        "name": "Polychromasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/polychromasia"
      },
      {
        "slug": "prolonged-neonatal-jaundice",
        "name": "Prolonged yellowing of skin in newborn",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/prolonged-neonatal-jaundice"
      },
      {
        "slug": "reduced-hematocrit",
        "name": "Reduced hematocrit",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-hematocrit"
      },
      {
        "slug": "reduced-red-cell-pyruvate-kinase-level",
        "name": "Reduced red cell pyruvate kinase level",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-red-cell-pyruvate-kinase-level"
      },
      {
        "slug": "schistocytosis",
        "name": "Schistocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/schistocytosis"
      },
      {
        "slug": "severe-infection",
        "name": "Severe infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/severe-infection"
      },
      {
        "slug": "micropenis",
        "name": "Short penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/micropenis"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "splenic-infarction",
        "name": "Splenic infarction",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/splenic-infarction"
      },
      {
        "slug": "target-cells",
        "name": "Target cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/target-cells"
      },
      {
        "slug": "unconjugated-hyperbilirubinemia",
        "name": "Unconjugated hyperbilirubinemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/unconjugated-hyperbilirubinemia"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "anisocytosis",
        "name": "Unequal size of red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anisocytosis"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/weight-loss"
      },
      {
        "slug": "wide-anterior-fontanel",
        "name": "Wider-than-typical soft spot of skull",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/wide-anterior-fontanel"
      }
    ],
    "related": [
      {
        "slug": "cdan1",
        "symbol": "CDAN1",
        "name": "codanin 1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cdan1"
      },
      {
        "slug": "cdin1",
        "symbol": "CDIN1",
        "name": "CDAN1 interacting nuclease 1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cdin1"
      },
      {
        "slug": "sec23b",
        "symbol": "SEC23B",
        "name": "SEC23 homolog B, COPII component",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/sec23b"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-e609d43e",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}