{
  "url": "https://dantelabs.com/lt/genes/gucy1a1",
  "gene": {
    "slug": "gucy1a1",
    "symbol": "GUCY1A1",
    "name": "guanylate cyclase 1 soluble subunit alpha 1",
    "hgnc": "HGNC:4685",
    "summary": null,
    "location": "4q32.1",
    "locusType": "gene with protein product",
    "aliases": [
      "GC-SA3"
    ],
    "previousSymbols": [
      "GUC1A3",
      "GUCY1A3"
    ],
    "ensemblId": "ENSG00000164116",
    "entrezId": 2982,
    "omim": [
      "139396"
    ],
    "uniprot": [
      "Q02108"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "4",
      "start": 155666848,
      "end": 155737059,
      "strand": "+",
      "ensemblTranscript": "ENST00000506455.6",
      "refseqTranscript": "NM_001130682.3",
      "ensemblProtein": "ENSP00000424361.1",
      "refseqProtein": "NP_001124154.1",
      "exons": [
        {
          "start": 155666848,
          "end": 155666965
        },
        {
          "start": 155667346,
          "end": 155667419
        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
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        },
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        },
        {
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          "end": 155737059
        }
      ],
      "cds": {
        "start": 155696868,
        "end": 155730231
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "4",
      "start": 156587863,
      "end": 156653501,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 155201954,
      "end": 156201953,
      "genes": [
        {
          "symbol": "NPY2R",
          "ensemblId": "ENSG00000185149",
          "biotype": "protein_coding",
          "start": 155208627,
          "end": 155217078,
          "strand": "+",
          "slug": "npy2r"
        },
        {
          "symbol": "MAP9",
          "ensemblId": "ENSG00000164114",
          "biotype": "protein_coding",
          "start": 155342658,
          "end": 155376970,
          "strand": "-",
          "slug": "map9"
        },
        {
          "symbol": "GUCY1B1",
          "ensemblId": "ENSG00000061918",
          "biotype": "protein_coding",
          "start": 155758988,
          "end": 155807811,
          "strand": "+",
          "slug": "gucy1b1"
        },
        {
          "symbol": "ASIC5",
          "ensemblId": "ENSG00000256394",
          "biotype": "protein_coding",
          "start": 155829729,
          "end": 155866277,
          "strand": "-",
          "slug": "asic5"
        },
        {
          "symbol": "TDO2",
          "ensemblId": "ENSG00000151790",
          "biotype": "protein_coding",
          "start": 155854738,
          "end": 155921470,
          "strand": "+",
          "slug": "tdo2"
        },
        {
          "symbol": "CTSO",
          "ensemblId": "ENSG00000256043",
          "biotype": "protein_coding",
          "start": 155921580,
          "end": 155953912,
          "strand": "-",
          "slug": "ctso"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "moyamoya-disease",
        "name": "Moyamoya liga",
        "diseases": [
          {
            "mondoId": "MONDO:0016820",
            "name": "Moyamoya liga",
            "genes": 4,
            "inheritance": null,
            "description": "Smegenų pagrindo arterijų progresuojantis susiaurėjimas, susijęs su RNF213 (polinkio genu su sumažėjusiu pasireiškimo dažniu, ypač dažnu Rytų Azijos populiacijose), ACTA2 ar GUCY1A1 pakitimais, kurie gali sukelti insultus ar mikroinsultus.",
            "management": "Žinojimas padeda laiku įvertinti tokius simptomus kaip laikinas silpnumas ir gauti specialistų taikomą insulto prevenciją bei chirurginį gydymą.",
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/moyamoya-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-platelet-aggregation",
        "name": "Abnormal platelet aggregation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-platelet-aggregation"
      },
      {
        "slug": "abnormal-cerebral-vascular-morphology",
        "name": "Abnormality of the cerebral blood vessels",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-cerebral-vascular-morphology"
      },
      {
        "slug": "achalasia",
        "name": "Achalasia",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/achalasia"
      },
      {
        "slug": "cutis-marmorata",
        "name": "Cutis marmorata",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cutis-marmorata"
      },
      {
        "slug": "impotence",
        "name": "Difficulty getting a full erection",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/impotence"
      },
      {
        "slug": "generalized-onset-seizure",
        "name": "Generalized-onset seizure",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/generalized-onset-seizure"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "ischemic-stroke",
        "name": "Ischemic stroke",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ischemic-stroke"
      },
      {
        "slug": "livedo-reticularis",
        "name": "Livedo reticularis",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/livedo-reticularis"
      },
      {
        "slug": "thrombocytopenia",
        "name": "Low platelet count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thrombocytopenia"
      },
      {
        "slug": "moyamoya-phenomenon",
        "name": "Moyamoya phenomenon",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/moyamoya-phenomenon"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "raynaud-phenomenon",
        "name": "Raynaud phenomenon",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/raynaud-phenomenon"
      },
      {
        "slug": "stroke",
        "name": "Stroke",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/stroke"
      },
      {
        "slug": "hemiparesis",
        "name": "Weakness of one side of body",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hemiparesis"
      }
    ],
    "related": [
      {
        "slug": "acta2",
        "symbol": "ACTA2",
        "name": "actin alpha 2, smooth muscle",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/acta2"
      },
      {
        "slug": "rnf213",
        "symbol": "RNF213",
        "name": "ring finger protein 213",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/rnf213"
      },
      {
        "slug": "samhd1",
        "symbol": "SAMHD1",
        "name": "SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/samhd1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}