{
  "url": "https://dantelabs.com/lt/genes/gpnmb",
  "gene": {
    "slug": "gpnmb",
    "symbol": "GPNMB",
    "name": "glycoprotein nmb",
    "hgnc": "HGNC:4462",
    "summary": null,
    "location": "7p15.3",
    "locusType": "gene with protein product",
    "aliases": [
      "NMB",
      "HGFIN"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000136235",
    "entrezId": 10457,
    "omim": [
      "604368"
    ],
    "uniprot": [
      "Q14956"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "7",
      "start": 23246775,
      "end": 23275108,
      "strand": "+",
      "ensemblTranscript": "ENST00000258733.9",
      "refseqTranscript": "NM_002510.3",
      "ensemblProtein": "ENSP00000258733.5",
      "refseqProtein": "NP_002501.1",
      "exons": [
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        },
        {
          "start": 23253307,
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        {
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        {
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        },
        {
          "start": 23259980,
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        },
        {
          "start": 23260456,
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        },
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        {
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        {
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        },
        {
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        },
        {
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        }
      ],
      "cds": {
        "start": 23246858,
        "end": 23274224
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
      "start": 23275586,
      "end": 23314727,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 22760942,
      "end": 23760941,
      "genes": [
        {
          "symbol": "TOMM7",
          "ensemblId": "ENSG00000196683",
          "biotype": "protein_coding",
          "start": 22812628,
          "end": 22822891,
          "strand": "-",
          "slug": "tomm7"
        },
        {
          "symbol": "HYCC1",
          "ensemblId": "ENSG00000122591",
          "biotype": "protein_coding",
          "start": 22889371,
          "end": 23014148,
          "strand": "-",
          "slug": "hycc1"
        },
        {
          "symbol": "KLHL7",
          "ensemblId": "ENSG00000122550",
          "biotype": "protein_coding",
          "start": 23105729,
          "end": 23177914,
          "strand": "+",
          "slug": "klhl7"
        },
        {
          "symbol": "NUP42",
          "ensemblId": "ENSG00000136243",
          "biotype": "protein_coding",
          "start": 23181804,
          "end": 23201011,
          "strand": "+",
          "slug": "nup42"
        },
        {
          "symbol": "MALSU1",
          "ensemblId": "ENSG00000156928",
          "biotype": "protein_coding",
          "start": 23298739,
          "end": 23311729,
          "strand": "+",
          "slug": "malsu1"
        },
        {
          "symbol": "IGF2BP3",
          "ensemblId": "ENSG00000136231",
          "biotype": "protein_coding",
          "start": 23308571,
          "end": 23470833,
          "strand": "-",
          "slug": "igf2bp3"
        },
        {
          "symbol": "TRA2A",
          "ensemblId": "ENSG00000164548",
          "biotype": "protein_coding",
          "start": 23504780,
          "end": 23532041,
          "strand": "-",
          "slug": "tra2a"
        },
        {
          "symbol": "CCDC126",
          "ensemblId": "ENSG00000169193",
          "biotype": "protein_coding",
          "start": 23597374,
          "end": 23644714,
          "strand": "+",
          "slug": "ccdc126"
        },
        {
          "symbol": "FAM221A",
          "ensemblId": "ENSG00000188732",
          "biotype": "protein_coding",
          "start": 23680114,
          "end": 23706228,
          "strand": "+",
          "slug": "fam221a"
        },
        {
          "symbol": "STK31",
          "ensemblId": "ENSG00000196335",
          "biotype": "protein_coding",
          "start": 23710203,
          "end": 23832513,
          "strand": "+",
          "slug": "stk31"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-amyloidosis-145",
        "name": "Paveldima amiloidozė",
        "diseases": [
          {
            "mondoId": "MONDO:0018634",
            "name": "Paveldima amiloidozė",
            "genes": 12,
            "inheritance": "autosomal-dominant",
            "description": "Paveldima amiloidozė – tai paveldimų ligų grupė, sudaranti vieną amiloidozės pogrupių. Paveldimai amiloidozei būdingas nenormalaus baltymo, vadinamo amiloidu, kaupimasis įvairiuose kūno organuose, kur jo neturėtų būti, dėl ko sutrinka audinių struktūra ir organų funkcijos. Paveldimos amiloidozės atveju amiloido nuosėdos dažniausiai susidaro širdies, inkstų ir nervų sistemos audiniuose. Nors paveldimos amiloidozės simptomai gali pasireikšti vaikystėje, dauguma žmonių simptomų pradeda jausti suaugusiems. \n\nYra daug paveldimos amiloidozės tipų, susijusių su skirtingomis genų mutacijomis ir nenormaliais baltymais. Dažniausias paveldimos amiloidozės tipas – transtiretino amiloidozė (ATTR), kai amiloido nuosėdas dažniausiai sudaro kepenyse gaminamas transtiretino baltymas. Kiti paveldimos amiloidozės pavyzdžiai, bet ne tik, yra apolipoproteino AI amiloidozė (A ApoAI), gelsolino amiloidozė (A Gel), lizocimo amiloidozė (A Lys), cistatino C amiloidozė (A Cys), fibrinogeno Aα grandinės amiloidozė (A Fib) ir apolipoproteino AII amiloidozė (A ApoAII).",
            "management": "Tafamidis (kinetinis stabilizatorius), patisiranas (RNR trukdymas), vutisiranas (RNR trukdymas), inotersenas (antisensas), kepenų transplantacija",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/hereditary-amyloidosis-145"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "dry-skin",
        "name": "Dry skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dry-skin"
      },
      {
        "slug": "generalized-hyperpigmentation",
        "name": "Generalized hyperpigmentation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/generalized-hyperpigmentation"
      },
      {
        "slug": "hypermelanotic-macule",
        "name": "Hyperpigmented skin patches",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/hypermelanotic-macule"
      },
      {
        "slug": "hypopigmented-macule",
        "name": "Hypopigmented macule",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypopigmented-macule"
      },
      {
        "slug": "pruritus",
        "name": "Itching",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pruritus"
      }
    ],
    "related": [
      {
        "slug": "apoa1",
        "symbol": "APOA1",
        "name": "apolipoprotein A1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/apoa1"
      },
      {
        "slug": "apoa4",
        "symbol": "APOA4",
        "name": "apolipoprotein A4",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/apoa4"
      },
      {
        "slug": "app",
        "symbol": "APP",
        "name": "amyloid beta precursor protein",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/app"
      },
      {
        "slug": "b2m",
        "symbol": "B2M",
        "name": "beta-2-microglobulin",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/b2m"
      },
      {
        "slug": "cst3",
        "symbol": "CST3",
        "name": "cystatin C",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cst3"
      },
      {
        "slug": "fga",
        "symbol": "FGA",
        "name": "fibrinogen alpha chain",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/fga"
      },
      {
        "slug": "gsn",
        "symbol": "GSN",
        "name": "gelsolin",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/gsn"
      },
      {
        "slug": "itm2b",
        "symbol": "ITM2B",
        "name": "integral membrane protein 2B",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/itm2b"
      },
      {
        "slug": "lyz",
        "symbol": "LYZ",
        "name": "lysozyme",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/lyz"
      },
      {
        "slug": "osmr",
        "symbol": "OSMR",
        "name": "oncostatin M receptor",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/osmr"
      },
      {
        "slug": "ttr",
        "symbol": "TTR",
        "name": "transthyretin",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/ttr"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}