{
  "url": "https://dantelabs.com/lt/genes/fam111a",
  "gene": {
    "slug": "fam111a",
    "symbol": "FAM111A",
    "name": "FAM111 trypsin like peptidase A",
    "hgnc": "HGNC:24725",
    "summary": null,
    "location": "11q12.1",
    "locusType": "gene with protein product",
    "aliases": [
      "FLJ22794",
      "KIAA1895"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000166801",
    "entrezId": 63901,
    "omim": [
      "615292"
    ],
    "uniprot": [
      "Q96PZ2"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 59142856,
      "end": 59155039,
      "strand": "+",
      "ensemblTranscript": "ENST00000675163.1",
      "refseqTranscript": "NM_001312909.2",
      "ensemblProtein": "ENSP00000501952.1",
      "refseqProtein": "NP_001299838.1",
      "exons": [
        {
          "start": 59142856,
          "end": 59142946
        },
        {
          "start": 59143083,
          "end": 59143304
        },
        {
          "start": 59143497,
          "end": 59143695
        },
        {
          "start": 59145827,
          "end": 59145856
        },
        {
          "start": 59148797,
          "end": 59148953
        },
        {
          "start": 59151750,
          "end": 59155039
        }
      ],
      "cds": {
        "start": 59148873,
        "end": 59153504
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 58910221,
      "end": 58922512,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 58648948,
      "end": 59648947,
      "genes": [
        {
          "symbol": "GLYAT",
          "ensemblId": "ENSG00000149124",
          "biotype": "protein_coding",
          "start": 58640426,
          "end": 58732010,
          "strand": "-",
          "slug": "glyat"
        },
        {
          "symbol": "GLYATL2",
          "ensemblId": "ENSG00000156689",
          "biotype": "protein_coding",
          "start": 58834065,
          "end": 58904215,
          "strand": "-",
          "slug": "glyatl2"
        },
        {
          "symbol": "GLYATL1",
          "ensemblId": "ENSG00000166840",
          "biotype": "protein_coding",
          "start": 58905398,
          "end": 59043527,
          "strand": "+",
          "slug": "glyatl1"
        },
        {
          "symbol": "GLYATL1B",
          "ensemblId": "ENSG00000255151",
          "biotype": "protein_coding",
          "start": 59086307,
          "end": 59094786,
          "strand": "+",
          "slug": "glyatl1b"
        },
        {
          "symbol": "FAM111B",
          "ensemblId": "ENSG00000189057",
          "biotype": "protein_coding",
          "start": 59107185,
          "end": 59128378,
          "strand": "+",
          "slug": "fam111b"
        },
        {
          "symbol": "DTX4",
          "ensemblId": "ENSG00000110042",
          "biotype": "protein_coding",
          "start": 59171430,
          "end": 59208600,
          "strand": "+",
          "slug": "dtx4"
        },
        {
          "symbol": "MPEG1",
          "ensemblId": "ENSG00000197629",
          "biotype": "protein_coding",
          "start": 59208510,
          "end": 59213474,
          "strand": "-",
          "slug": "mpeg1"
        },
        {
          "symbol": "OR5AN1",
          "ensemblId": "ENSG00000176495",
          "biotype": "protein_coding",
          "start": 59358895,
          "end": 59371714,
          "strand": "+",
          "slug": "or5an1"
        },
        {
          "symbol": "OR5A2",
          "ensemblId": "ENSG00000172324",
          "biotype": "protein_coding",
          "start": 59416969,
          "end": 59426413,
          "strand": "-",
          "slug": "or5a2"
        },
        {
          "symbol": "OR5A1",
          "ensemblId": "ENSG00000172320",
          "biotype": "protein_coding",
          "start": 59436469,
          "end": 59451380,
          "strand": "+",
          "slug": "or5a1"
        },
        {
          "symbol": "OR4D6",
          "ensemblId": "ENSG00000166884",
          "biotype": "protein_coding",
          "start": 59456961,
          "end": 59457905,
          "strand": "+",
          "slug": "or4d6"
        },
        {
          "symbol": "OR4D10",
          "ensemblId": "ENSG00000254466",
          "biotype": "protein_coding",
          "start": 59473315,
          "end": 59479361,
          "strand": "+",
          "slug": "or4d10"
        },
        {
          "symbol": "OR4D11",
          "ensemblId": "ENSG00000176200",
          "biotype": "protein_coding",
          "start": 59503576,
          "end": 59504511,
          "strand": "+",
          "slug": "or4d11"
        },
        {
          "symbol": "OR4D9",
          "ensemblId": "ENSG00000172742",
          "biotype": "protein_coding",
          "start": 59511368,
          "end": 59520703,
          "strand": "+",
          "slug": "or4d9"
        },
        {
          "symbol": "OSBP",
          "ensemblId": "ENSG00000110048",
          "biotype": "protein_coding",
          "start": 59574398,
          "end": 59615792,
          "strand": "-",
          "slug": "osbp"
        },
        {
          "symbol": "PATL1",
          "ensemblId": "ENSG00000166889",
          "biotype": "protein_coding",
          "start": 59636470,
          "end": 59669162,
          "strand": "-",
          "slug": "patl1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-circulating-follicle-stimulating-hormone-concentration",
        "name": "Abnormal circulating follicle-stimulating hormone concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-follicle-stimulating-hormone-concentration"
      },
      {
        "slug": "abnormality-of-the-medullary-cavity-of-the-long-bones",
        "name": "Abnormality of the marrow cavity of the long bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-medullary-cavity-of-the-long-bones"
      },
      {
        "slug": "microphthalmia",
        "name": "Abnormally small eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/microphthalmia"
      },
      {
        "slug": "bilateral-microphthalmos",
        "name": "Abnormally small eyeball on both sides",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bilateral-microphthalmos"
      },
      {
        "slug": "aniridia",
        "name": "Absent iris",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/aniridia"
      },
      {
        "slug": "asplenia",
        "name": "Absent spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asplenia"
      },
      {
        "slug": "ascites",
        "name": "Accumulation of fluid in the abdomen",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/ascites"
      },
      {
        "slug": "basal-ganglia-calcification",
        "name": "Basal ganglia calcification",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/basal-ganglia-calcification"
      },
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/macrocephaly"
      },
      {
        "slug": "calvarial-osteosclerosis",
        "name": "Calvarial osteosclerosis",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/calvarial-osteosclerosis"
      },
      {
        "slug": "developmental-cataract",
        "name": "Clouding of the lens of the eye at birth",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/developmental-cataract"
      },
      {
        "slug": "congenital-hypoparathyroidism",
        "name": "Congenital hypoparathyroidism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/congenital-hypoparathyroidism"
      },
      {
        "slug": "cortical-thickening-of-long-bone-diaphyses",
        "name": "Cortical thickening of long bone diaphyses",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cortical-thickening-of-long-bone-diaphyses"
      },
      {
        "slug": "decreased-skull-ossification",
        "name": "Decreased bone formation of skull",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-skull-ossification"
      },
      {
        "slug": "hypoparathyroidism",
        "name": "Decreased parathyroid hormone secretion",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/hypoparathyroidism"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "delayed-skeletal-maturation",
        "name": "Delayed bone maturation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-skeletal-maturation"
      },
      {
        "slug": "delayed-closure-of-the-anterior-fontanelle",
        "name": "Delayed closure of the soft spot on the skull",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/delayed-closure-of-the-anterior-fontanelle"
      },
      {
        "slug": "delayed-cranial-suture-closure",
        "name": "Delayed cranial suture closure",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-cranial-suture-closure"
      },
      {
        "slug": "persistence-of-primary-teeth",
        "name": "Delayed loss of baby teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/persistence-of-primary-teeth"
      },
      {
        "slug": "carious-teeth",
        "name": "Dental cavities",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/carious-teeth"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "hypermetropia",
        "name": "Farsightedness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypermetropia"
      },
      {
        "slug": "flared-metaphysis",
        "name": "Flared wide portion of long bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/flared-metaphysis"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "postnatal-growth-retardation",
        "name": "Growth delay as children",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/postnatal-growth-retardation"
      },
      {
        "slug": "hyperphosphatemia",
        "name": "High blood phosphate levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperphosphatemia"
      },
      {
        "slug": "abnormally-high-pitched-voice",
        "name": "High pitched voice",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormally-high-pitched-voice"
      },
      {
        "slug": "hypocalcemic-tetany",
        "name": "Hypocalcemic tetany",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypocalcemic-tetany"
      },
      {
        "slug": "increased-bone-mineral-density",
        "name": "Increased bone mineral density",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/increased-bone-mineral-density"
      },
      {
        "slug": "hypocalcemia",
        "name": "Low blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypocalcemia"
      },
      {
        "slug": "hypocalcemic-seizures",
        "name": "Low calcium seizures",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypocalcemic-seizures"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "papilledema",
        "name": "Papilledema",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/papilledema"
      },
      {
        "slug": "postnatal-macrocephaly",
        "name": "Postnatal macrocephaly",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/postnatal-macrocephaly"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "prominent-forehead",
        "name": "Prominent forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prominent-forehead"
      },
      {
        "slug": "retinal-calcification",
        "name": "Retinal calcification",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/retinal-calcification"
      },
      {
        "slug": "severe-short-stature",
        "name": "Severe short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/severe-short-stature"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "micropenis",
        "name": "Short penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/micropenis"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "slender-long-bone",
        "name": "Slender long bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/slender-long-bone"
      },
      {
        "slug": "small-for-gestational-age",
        "name": "Small for gestational age",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/small-for-gestational-age"
      },
      {
        "slug": "stenosis-of-the-medullary-cavity-of-the-long-bones",
        "name": "Stenosis of the medullary cavity of the long bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/stenosis-of-the-medullary-cavity-of-the-long-bones"
      },
      {
        "slug": "thickened-cortex-of-long-bones",
        "name": "Thickened cortex of long bones",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/thickened-cortex-of-long-bones"
      },
      {
        "slug": "thin-ribs",
        "name": "Thin ribs",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/thin-ribs"
      },
      {
        "slug": "thin-long-bone-diaphyses",
        "name": "Thin shaft of long bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thin-long-bone-diaphyses"
      },
      {
        "slug": "ankyloglossia",
        "name": "Tongue tied",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/ankyloglossia"
      },
      {
        "slug": "hydrocephalus",
        "name": "Too much cerebrospinal fluid in the brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hydrocephalus"
      },
      {
        "slug": "hypoplastic-spleen",
        "name": "Underdeveloped spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplastic-spleen"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}