{
  "url": "https://dantelabs.com/lt/genes/cyp11b1",
  "gene": {
    "slug": "cyp11b1",
    "symbol": "CYP11B1",
    "name": "cytochrome P450 family 11 subfamily B member 1",
    "hgnc": "HGNC:2591",
    "summary": null,
    "location": "8q24.3",
    "locusType": "gene with protein product",
    "aliases": [
      "P450C11",
      "FHI",
      "CPN1"
    ],
    "previousSymbols": [
      "CYP11B"
    ],
    "ensemblId": "ENSG00000160882",
    "entrezId": 1584,
    "omim": [
      "610613"
    ],
    "uniprot": [
      "P15538"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
      "start": 142872357,
      "end": 142879825,
      "strand": "-",
      "ensemblTranscript": "ENST00000292427.10",
      "refseqTranscript": "NM_000497.4",
      "ensemblProtein": "ENSP00000292427.5",
      "refseqProtein": "NP_000488.3",
      "exons": [
        {
          "start": 142872357,
          "end": 142874486
        },
        {
          "start": 142874957,
          "end": 142875154
        },
        {
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          "end": 142875312
        },
        {
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          "end": 142875878
        },
        {
          "start": 142876241,
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        },
        {
          "start": 142876682,
          "end": 142876885
        },
        {
          "start": 142877023,
          "end": 142877222
        },
        {
          "start": 142879032,
          "end": 142879187
        },
        {
          "start": 142879575,
          "end": 142879825
        }
      ],
      "cds": {
        "start": 142874373,
        "end": 142879813
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
      "start": 143953772,
      "end": 143961262,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 142376091,
      "end": 143376090,
      "genes": [
        {
          "symbol": "TSNARE1",
          "ensemblId": "ENSG00000171045",
          "biotype": "protein_coding",
          "start": 142212077,
          "end": 142403270,
          "strand": "-",
          "slug": "tsnare1"
        },
        {
          "symbol": "ADGRB1",
          "ensemblId": "ENSG00000181790",
          "biotype": "protein_coding",
          "start": 142449430,
          "end": 142545009,
          "strand": "+",
          "slug": "adgrb1"
        },
        {
          "symbol": "ARC",
          "ensemblId": "ENSG00000198576",
          "biotype": "protein_coding",
          "start": 142611049,
          "end": 142614479,
          "strand": "-",
          "slug": "arc"
        },
        {
          "symbol": "JRK",
          "ensemblId": "ENSG00000234616",
          "biotype": "protein_coding",
          "start": 142657460,
          "end": 142681968,
          "strand": "-",
          "slug": "jrk"
        },
        {
          "symbol": "PSCA",
          "ensemblId": "ENSG00000167653",
          "biotype": "protein_coding",
          "start": 142670308,
          "end": 142682725,
          "strand": "+",
          "slug": "psca"
        },
        {
          "symbol": "LY6K",
          "ensemblId": "ENSG00000160886",
          "biotype": "protein_coding",
          "start": 142699988,
          "end": 142705190,
          "strand": "+",
          "slug": "ly6k"
        },
        {
          "symbol": "THEM6",
          "ensemblId": "ENSG00000130193",
          "biotype": "protein_coding",
          "start": 142727176,
          "end": 142736938,
          "strand": "+",
          "slug": "them6"
        },
        {
          "symbol": "SLURP1",
          "ensemblId": "ENSG00000126233",
          "biotype": "protein_coding",
          "start": 142740941,
          "end": 142742414,
          "strand": "-",
          "slug": "slurp1"
        },
        {
          "symbol": "LYPD2",
          "ensemblId": "ENSG00000197353",
          "biotype": "protein_coding",
          "start": 142750150,
          "end": 142753006,
          "strand": "-",
          "slug": "lypd2"
        },
        {
          "symbol": "SLURP2",
          "ensemblId": "ENSG00000283992",
          "biotype": "protein_coding",
          "start": 142764334,
          "end": 142769828,
          "strand": "-",
          "slug": "slurp2"
        },
        {
          "symbol": "LYNX1-SLURP2",
          "ensemblId": "ENSG00000284505",
          "biotype": "protein_coding",
          "start": 142764334,
          "end": 142778224,
          "strand": "-",
          "slug": "lynx1-slurp2"
        },
        {
          "symbol": "LYNX1",
          "ensemblId": "ENSG00000180155",
          "biotype": "protein_coding",
          "start": 142771197,
          "end": 142777889,
          "strand": "-",
          "slug": "lynx1"
        },
        {
          "symbol": "LY6D",
          "ensemblId": "ENSG00000167656",
          "biotype": "protein_coding",
          "start": 142784881,
          "end": 142786546,
          "strand": "-",
          "slug": "ly6d"
        },
        {
          "symbol": "GML",
          "ensemblId": "ENSG00000104499",
          "biotype": "protein_coding",
          "start": 142834171,
          "end": 142916506,
          "strand": "+",
          "slug": "gml"
        },
        {
          "symbol": "CYP11B2",
          "ensemblId": "ENSG00000179142",
          "biotype": "protein_coding",
          "start": 142910424,
          "end": 142917943,
          "strand": "-",
          "slug": "cyp11b2"
        },
        {
          "symbol": "LY6E",
          "ensemblId": "ENSG00000160932",
          "biotype": "protein_coding",
          "start": 143012722,
          "end": 143023835,
          "strand": "+",
          "slug": "ly6e"
        },
        {
          "symbol": "LY6S",
          "ensemblId": "ENSG00000291309",
          "biotype": "protein_coding",
          "start": 143040839,
          "end": 143048357,
          "strand": "-",
          "slug": "ly6s"
        },
        {
          "symbol": "LY6L",
          "ensemblId": "ENSG00000261667",
          "biotype": "protein_coding",
          "start": 143080299,
          "end": 143083486,
          "strand": "+",
          "slug": "ly6l"
        },
        {
          "symbol": "LY6H",
          "ensemblId": "ENSG00000176956",
          "biotype": "protein_coding",
          "start": 143157914,
          "end": 143160711,
          "strand": "-",
          "slug": "ly6h"
        },
        {
          "symbol": "GPIHBP1",
          "ensemblId": "ENSG00000277494",
          "biotype": "protein_coding",
          "start": 143213019,
          "end": 143217172,
          "strand": "+",
          "slug": "gpihbp1"
        },
        {
          "symbol": "ZFP41",
          "ensemblId": "ENSG00000181638",
          "biotype": "protein_coding",
          "start": 143245996,
          "end": 143262705,
          "strand": "+",
          "slug": "zfp41"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000264668",
          "biotype": "protein_coding",
          "start": 143247110,
          "end": 143276403,
          "strand": "+"
        },
        {
          "symbol": "GLI4",
          "ensemblId": "ENSG00000250571",
          "biotype": "protein_coding",
          "start": 143263193,
          "end": 143276937,
          "strand": "+",
          "slug": "gli4"
        },
        {
          "symbol": "ZNF696",
          "ensemblId": "ENSG00000185730",
          "biotype": "protein_coding",
          "start": 143289676,
          "end": 143299952,
          "strand": "+",
          "slug": "znf696"
        },
        {
          "symbol": "TOP1MT",
          "ensemblId": "ENSG00000184428",
          "biotype": "protein_coding",
          "start": 143301453,
          "end": 143359979,
          "strand": "-",
          "slug": "top1mt"
        },
        {
          "symbol": "RHPN1",
          "ensemblId": "ENSG00000158106",
          "biotype": "protein_coding",
          "start": 143368810,
          "end": 143384221,
          "strand": "+",
          "slug": "rhpn1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-adrenal-hyperplasia",
        "name": "Įgimta antinksčių hiperplazija",
        "diseases": [
          {
            "mondoId": "MONDO:0018479",
            "name": "Įgimta antinksčių hiperplazija",
            "genes": 6,
            "inheritance": "autosomal-recessive",
            "description": "Įgimta antinksčių hiperplazija (ĮAH) yra paveldima endokrininė liga, kurią sukelia steroidogenezės fermento nepakankamumas. Ją apibūdina antinksčių nepakankamumas ir įvairaus laipsnio hiperandrogenizmo ar hipoandrogenizmo požymiai, priklausomai nuo ligos tipo ir sunkumo.",
            "management": "Gliukokortikoidų pakaitinis gydymas (vaikams – hidrokortizonas, suaugusiesiems – prednizonas / deksametazonas); mineralokortikoidų pakaitinis gydymas druskos netekimo atveju (fludrokortizonas); antinksčių pašalinimas (adrenalektomija) sunkiu, vaistais nepasiduodančiu hiperandrogenizmu; gydymo dozių koregavimo protokolai stresinėse situacijose",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "Myriad Women's Health",
                "Natera"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/congenital-adrenal-hyperplasia"
      },
      {
        "slug": "monogenic-hypertension-mineralocorticoid-disorders",
        "name": "Monogeninė hipertenzija ir mineralokortikoidų sutrikimai",
        "diseases": [
          {
            "mondoId": "MONDO:0016525",
            "name": "Šeiminė hiperaldosteronizmas",
            "genes": 4,
            "inheritance": "autosomal-dominant",
            "description": "Ligų grupė, įskaitant glikokortikoidais valdomą aldosteronizmą (CYP11B1/CYP11B2) ir formas, sukeltas CLCN2, KCNJ5 ar CACNA1H, kai antinksčiai gamina per daug aldosterono, todėl pakyla kraujospūdis.",
            "management": "Žinojimas apie šią ligą padeda parinkti gydymą (deksametazonas glikokortikoidais valdomo aldosteronizmo atveju, apskritai vaistai, blokuojantys aldosteroną) ir padeda tikrinti giminaičius.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/lt/conditions/monogenic-hypertension-mineralocorticoid-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "acne",
        "name": "Acne",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/acne"
      },
      {
        "slug": "adrenogenital-syndrome",
        "name": "Adrenogenital syndrome",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/adrenogenital-syndrome"
      },
      {
        "slug": "accelerated-skeletal-maturation",
        "name": "Advanced bone age",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/accelerated-skeletal-maturation"
      },
      {
        "slug": "ambiguous-genitalia",
        "name": "Ambiguous external genitalia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/ambiguous-genitalia"
      },
      {
        "slug": "ambiguous-genitalia-female",
        "name": "Atypical appearance of female genitals",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ambiguous-genitalia-female"
      },
      {
        "slug": "intracranial-hemorrhage",
        "name": "Bleeding within the skull",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intracranial-hemorrhage"
      },
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "dilatation-of-the-cerebral-artery",
        "name": "Brain aneurysm",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dilatation-of-the-cerebral-artery"
      },
      {
        "slug": "congenital-adrenal-hyperplasia",
        "name": "Congenital adrenal hyperplasia",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/congenital-adrenal-hyperplasia"
      },
      {
        "slug": "decreased-circulating-renin-concentration",
        "name": "Decreased circulating renin concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-renin-concentration"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "precocious-puberty",
        "name": "Early onset of puberty",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/precocious-puberty"
      },
      {
        "slug": "precocious-puberty-in-males",
        "name": "Early onset of puberty in males",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/precocious-puberty-in-males"
      },
      {
        "slug": "elevated-aldosterone-renin-ratio",
        "name": "Elevated aldosterone:renin ratio",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-aldosterone-renin-ratio"
      },
      {
        "slug": "elevated-circulating-17-hydroxyprogesterone-concentration",
        "name": "Elevated circulating 17-hydroxyprogesterone concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-17-hydroxyprogesterone-concentration"
      },
      {
        "slug": "increased-circulating-aldosterone-concentration",
        "name": "Elevated plasma aldosterone",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-aldosterone-concentration"
      },
      {
        "slug": "elevated-serum-11-deoxycortisol",
        "name": "Elevated serum 11-deoxycortisol",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-serum-11-deoxycortisol"
      },
      {
        "slug": "adrenal-hyperplasia",
        "name": "Enlarged adrenal glands",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/adrenal-hyperplasia"
      },
      {
        "slug": "clitoral-hypertrophy",
        "name": "Enlarged clitoris",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/clitoral-hypertrophy"
      },
      {
        "slug": "gynecomastia",
        "name": "Enlarged male breast",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gynecomastia"
      },
      {
        "slug": "hirsutism",
        "name": "Excessive hairiness",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hirsutism"
      },
      {
        "slug": "polydipsia",
        "name": "Extreme thirst",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/polydipsia"
      },
      {
        "slug": "growth-abnormality",
        "name": "Growth abnormality",
        "systems": [],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/growth-abnormality"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "hypertension-resistant-to-conventional-therapy",
        "name": "Hypertension resistant to conventional therapy",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertension-resistant-to-conventional-therapy"
      },
      {
        "slug": "increased-circulating-acth-level",
        "name": "Increased circulating ACTH level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-acth-level"
      },
      {
        "slug": "increased-circulating-androgen-concentration",
        "name": "Increased circulating androgen concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-androgen-concentration"
      },
      {
        "slug": "increased-circulating-androstenedione-concentration",
        "name": "Increased circulating androstenedione concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-androstenedione-concentration"
      },
      {
        "slug": "increased-serum-testosterone-level",
        "name": "Increased testosterone",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-serum-testosterone-level"
      },
      {
        "slug": "increased-urinary-11-deoxycorticosterone-level",
        "name": "Increased urinary 11-deoxycorticosterone level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-urinary-11-deoxycorticosterone-level"
      },
      {
        "slug": "isosexual-precocious-puberty",
        "name": "Isosexual precocious puberty",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/isosexual-precocious-puberty"
      },
      {
        "slug": "left-ventricular-hypertrophy",
        "name": "Left ventricular hypertrophy",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/left-ventricular-hypertrophy"
      },
      {
        "slug": "long-penis",
        "name": "Long penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/long-penis"
      },
      {
        "slug": "renal-salt-wasting",
        "name": "Loss of salt in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-salt-wasting"
      },
      {
        "slug": "decreased-circulating-aldosterone-concentration",
        "name": "Low blood aldosterone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-aldosterone-concentration"
      },
      {
        "slug": "decreased-circulating-cortisol-level",
        "name": "Low blood cortisol level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-cortisol-level"
      },
      {
        "slug": "hypokalemia",
        "name": "Low blood potassium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypokalemia"
      },
      {
        "slug": "irregular-menstruation",
        "name": "Menstrual irregularity",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/irregular-menstruation"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "nausea",
        "name": "Nausea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nausea"
      },
      {
        "slug": "retinopathy",
        "name": "Noninflammatory retina disease",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinopathy"
      },
      {
        "slug": "hyperpigmentation-of-the-skin",
        "name": "Patchy darkened skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperpigmentation-of-the-skin"
      },
      {
        "slug": "polycystic-ovaries",
        "name": "Polycystic ovaries",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/polycystic-ovaries"
      },
      {
        "slug": "premature-adrenarche",
        "name": "Premature adrenarche",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/premature-adrenarche"
      },
      {
        "slug": "premature-thelarche",
        "name": "Premature breast development",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/premature-thelarche"
      },
      {
        "slug": "premature-pubarche",
        "name": "Premature pubic hair growth",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/premature-pubarche"
      },
      {
        "slug": "tinnitus",
        "name": "Ringing in ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tinnitus"
      },
      {
        "slug": "secretory-adrenocortical-adenoma",
        "name": "Secretory adrenocortical adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/secretory-adrenocortical-adenoma"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "hypoplasia-of-the-uterus",
        "name": "Small uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-uterus"
      },
      {
        "slug": "stroke",
        "name": "Stroke",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/stroke"
      },
      {
        "slug": "testicular-adrenal-rest-tumor",
        "name": "Testicular adrenal rest tumor",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/testicular-adrenal-rest-tumor"
      },
      {
        "slug": "hypoplasia-of-the-vagina",
        "name": "Underdeveloped vagina",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-vagina"
      },
      {
        "slug": "abnormality-of-the-urinary-system",
        "name": "Urinary tract abnormalities",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-urinary-system"
      }
    ],
    "related": [
      {
        "slug": "cacna1d",
        "symbol": "CACNA1D",
        "name": "calcium voltage-gated channel subunit alpha1 D",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cacna1d"
      },
      {
        "slug": "cacna1h",
        "symbol": "CACNA1H",
        "name": "calcium voltage-gated channel subunit alpha1 H",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cacna1h"
      },
      {
        "slug": "cyp17a1",
        "symbol": "CYP17A1",
        "name": "cytochrome P450 family 17 subfamily A member 1",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cyp17a1"
      },
      {
        "slug": "cyp21a2",
        "symbol": "CYP21A2",
        "name": "cytochrome P450 family 21 subfamily A member 2",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/cyp21a2"
      },
      {
        "slug": "hsd3b2",
        "symbol": "HSD3B2",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/hsd3b2"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/kcnj5"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "name": "cytochrome p450 oxidoreductase",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/por"
      },
      {
        "slug": "star",
        "symbol": "STAR",
        "name": "steroidogenic acute regulatory protein",
        "shared": 1,
        "url": "https://dantelabs.com/lt/genes/star"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}